Impacts of basin-scale climate modes on coastal sea level: a review

Global sea level rise (SLR) associated with a warming climate exerts significant stress on coastal societies and low-lying island regions. The rates of coastal SLR observed in the past few decades, however, have large spatial and temporal differences from the global mean, which to a large part have been attributed to basin-scale climate modes. In this paper, we review our current state of knowledge about climate modes’ impacts on coastal sea level variability from interannual-to-multidecadal timescales. Relevant climate modes, their impacts and associated driving mechanisms through both remote and local processes are elaborated separately for the Pacific, Indian and Atlantic Oceans. This paper also identifies major issues and challenges for future research on climate modes’ impacts on coastal sea level. Understanding the effects of climate modes is essential for skillful near-term predictions and reliable uncertainty quantifications for future projections of coastal SLR

Impact Analysis of Energy Storage Participating in Peak Shaving and Valley Filling for Distribution Network on Network Loss and Voltage Deviation

[Introduction] The application scenarios of peak shaving and valley filling by energy storage connected to the distribution network are studied to clarify the influence of energy storage access on network losses and voltage quality on the distribution network side. [Method] The paper analyzed the change trend of network loss power with the energy storage injection current and access position during peak hours of energy storage discharge, and then analyzed the change trend of network loss power with the energy storage injection current and access position when the energy storage system was connected and charged during valley hours. For the influence of energy storage connected to the distribution network for peak shaving and valley filling on the voltage of the distribution network, the influence of different energy storage injection currents and access positions on the voltage distribution along the distribution network was studied from the perspective of energy storage discharge during peak hours and energy storage charging during valley hours. Finally, considering the total voltage deviation index of the distribution network, the influence on the total voltage deviation index after the distribution network which was connected to energy storage was studied. [Result] Through simulation calculations, the influence trend of energy storage participating in peak shaving and valley filling for the distribution network on network loss power and voltage loss is analyzed when different fixed or continuous values of energy storage current and access position are taken, and it is compared with theoretical analysis. [Conclusion] The study will provide useful references for the coordinated planning and optimized operation of various energy storage facilities in the distribution network, and it has good engineering reference value

CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1

<p>Macroautophagy/autophagy is an important intracellular mechanism for the maintenance of cellular homeostasis. Here we show that the <i>CERKL</i> (ceramide kinase like) gene, a retinal degeneration (RD) pathogenic gene, plays a critical role in regulating autophagy by stabilizing SIRT1. <i>In vitro</i> and <i>in vivo</i>, suppressing CERKL results in impaired autophagy. SIRT1 is one of the main regulators of acetylation/deacetylation in autophagy. In CERKL-depleted retinas and cells, SIRT1 is downregulated. ATG5 and ATG7, 2 essential components of autophagy, show a higher degree of acetylation in CERKL-depleted cells. Overexpression of SIRT1 rescues autophagy in CERKL-depleted cells, whereas CERKL loses its function of regulating autophagy in SIRT1-depleted cells, and overexpression of CERKL upregulates SIRT1. Finally, we show that CERKL directly interacts with SIRT1, and may regulate its phosphorylation at Ser27 to stabilize SIRT1. These results show that CERKL is an important regulator of autophagy and it plays this role by stabilizing the deacetylase SIRT1.</p

Social anxiety mediates between victimization experiences and internet addiction among adolescents: results from propensity score matching

BackgroundPrevious research has indicated that Victimization Experiences (VE) may be linked to a heightened likelihood of developing psychological symptoms and Internet Addiction (IA) among adolescents. However, the precise mechanism through which VE contributes to IA in adolescents remains uncertain. This study aimed to investigate whether Social Anxiety (SA) serves as a mediation between VE and IA, utilizing the framework of General Strain Theory.MethodsA cross-sectional survey among 11 middle schools or high schools in Macao was conducted from October to December 2022. Respondents in the victimized group and non-victimized group were 1:1 paired using Propensity Score Matching (PSM) to control the potential confounding factors.ResultsA total of 1,089 questionnaires were valid for analysis and 311 pairs were generated through PSM. Respondents in the victimized group reported significantly higher IA than those in non-victimized group (23.5% vs. 12.5%, p &lt; 0.001) after PSM treatment. Multivariate logistic regression analysis showed that VE (p = 0.015, OR = 1.750, 95% CI = 1.115 to 2.746, E-value = 2.90) and SA (p &lt; 0.001, OR = 1.052, 95% CI = 1.030 to 1.074, E-value = 1.29) were the predictors of IA. The model successfully classified 81.7% of cases overall (R2N = 0.133). Further analysis indicated that SA mediates between VE and IA (Z = 3.644, p &lt; 0.001).ConclusionThis study revealed the potential mediation effect of SA on the link between VE and IA. By acknowledging the mediating influence of SA, researchers and practitioners can develop more accurate and effective strategies to mitigate Internet Addiction among adolescents

Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy

Mutations in EYS are associated with autosomal recessive retinitis pigmentosa (arRP) and autosomal recessive cone-rod dystrophy (arCRD) however, the function of EYS and the molecular mechanisms of how these mutations cause retinal degeneration are still unclear. Because EYS is absent in mouse and rat, and the structure of the retina differs substantially between humans and Drosophila, we utilised zebrafish as a model organism to study the function of EYS in the retina. We constructed an EYS-knockout zebrafish-line by TALEN technology which showed visual impairment at an early age, while the histological and immunofluorescence assays indicated the presence of progressive retinal degeneration with a cone predominately affected pattern. These phenotypes recapitulate the clinical manifestations of arCRD patients. Furthermore, the EYS(−/−) zebrafish also showed mislocalisation of certain outer segment proteins (rhodopsin, opn1lw, opn1sw1, GNB3 and PRPH2), and disruption of actin filaments in photoreceptors. Protein mislocalisation may, therefore, disrupt the function of cones and rods in these zebrafish and cause photoreceptor death. Collectively, these results point to a novel role for EYS in maintaining the morphological structure of F-actin and in protein transport, loss of this function might be the trigger for the resultant cellular events that ultimately lead to photoreceptor death