Topological quantum memory interfacing atomic and superconducting qubits

We propose a scheme to manipulate a topological spin qubit which is realized with cold atoms in a one-dimensional optical lattice. In particular, by introducing a quantum opto-electro-mechanical interface, we are able to first transfer a superconducting qubit state to an atomic qubit state and then to store it into the topological spin qubit. In this way, an efficient topological quantum memory could be constructed for the superconducting qubit. Therefore, we can consolidate the advantages of both the noise resistance of the topological qubits and the scalability of the superconducting qubits in this hybrid architecture.Comment: v2: Accepted for publication in Science China-Physics, Mechanics & Astronom

Investigation of transpiration cooling with local thermal non-equilibrium model: Effects of different thermal boundary conditions at the porous-fluid interface

In this study, the main stream coupled with a porous medium with local thermal non-equilibrium assumption is analyzed. The flow inside the porous material is modelled using the Darcy–Brinkman–Forchheimer equation and the incompressible Navier-Stokes equations are solved for the main stream. Several couple conditions between the main flow temperature and the temperatures of the solid matrix and coolant flow at the fluid/porous interface is calculated. The results show that the Model C assumes the main flow temperature equals the solid phase temperature and the main flow heat flux is all imposed on the solid phase gives the most reasonable answer

Clinical Study on Local Application of Lidocaine in Reducing the Rate of Maternal Perineal Incision

Objective: To carry out feasibility study and determine the effect of local lidocaine in reducing the rate of maternal perineal incision. Method: A retrospective study of our hospital in January 2010 January 2012, with 80 cases of local application of lidocaine after perineal side cut lying in women and in the same period were randomly selected and 100 cases of conventional guild shade side cut of mother’s surgery as control group. Results: There was no difference between the weight of the newborn and the experimental group at the time of birth. The use of local lidocaine can reduce the rate of maternal perineal incision. Besides, in experimental group it show reduce in maternal postpartum hemorrhage and incision infection, with not increase the incidence of neonatal asphyxia. Conclusion: The use of local lidocaine in reduce the rate of maternal perineal incision is a simple, safe and reliable method to reduce the pain during delivery

Bis[3-(meth­oxy­carbon­yl)anilinium] hexa­chloridostannate(IV)

In the title compound, (NH3C6H4CO2CH3)2[SnCl6], the anions are situated on inversion centers so the asymmetric unit contains one cation and one half-anion. In the crystal, inter­molecular N—H⋯Cl and N—H⋯O hydrogen bonds link the cations and anions into layers parallel to the ac plane. The crystal packing exhibits voids of 37 Å3

Bis(4-acetyl­anilinium) hexa­chlorido­stannate(IV)

In the title compound, (C8H10NO)2[SnCl6], the SnIV atom exists in an octa­hedral coordination environment. In the crystal, inter­molecular N—H⋯O and N—H⋯Cl hydrogen bonds link the cations and anions into a three-dimensional framework

Integrative analysis of DNA methylomes reveals novel cell-free biomarkers in lung adenocarcinoma

Lung cancer is a leading cause of cancer-related deaths worldwide, with a low 5-year survival rate due in part to a lack of clinically useful biomarkers. Recent studies have identified DNA methylation changes as potential cancer biomarkers. The present study identified cancer-specific CpG methylation changes by comparing genome-wide methylation data of cfDNA from lung adenocarcinomas (LUAD) patients and healthy donors in the discovery cohort. A total of 725 cell-free CpGs associated with LUAD risk were identified. Then XGBoost algorithm was performed to identify seven CpGs associated with LUAD risk. In the training phase, the 7-CpGs methylation panel was established to classify two different prognostic subgroups and showed a significant association with overall survival (OS) in LUAD patients. We found that the methylation of cg02261780 was negatively correlated with the expression of its representing gene GNA11. The methylation and expression of GNA11 were significantly associated with LAUD prognosis. Based on bisulfite PCR, the methylation levels of five CpGs (cg02261780, cg09595050, cg20193802, cg15309457, and cg05726109) were further validated in tumor tissues and matched non-malignant tissues from 20 LUAD patients. Finally, validation of the seven CpGs with RRBS data of cfDNA methylation was conducted and further proved the reliability of the 7-CpGs methylation panel. In conclusion, our study identified seven novel methylation markers from cfDNA methylation data which may contribute to better prognosis for LUAD patients

Increased Methylation of the MOR Gene Proximal Promoter in Primary Sensory Neurons Plays a Crucial Role in the Decreased Analgesic Effect of Opioids in Neuropathic Pain

BACKGROUND: The analgesic potency of opioids is reduced in neuropathic pain. However, the molecular mechanism is not well understood. RESULTS: The present study demonstrated that increased methylation of the Mu opioid receptor (MOR) gene proximal promoter (PP) in dorsal root ganglion (DRG) plays a crucial role in the decreased morphine analgesia. Subcutaneous (s.c.), intrathecal (i.t.) and intraplantar (i.pl.), not intracerebroventricular (i.c.v.) injection of morphine, the potency of morphine analgesia was significantly reduced in nerve-injured mice compared with control sham-operated mice. After peripheral nerve injury, we observed a decreased expression of MOR protein and mRNA, accompanied by an increased methylation status of MOR gene PP, in DRG. However, peripheral nerve injury could not induce a decreased expression of MOR mRNA in the spinal cord. Treatment with 5-aza-2′-deoxycytidine (5-aza-dC), inhibited the increased methylation of MOR gene PP and prevented the decreased expression of MOR in DRG, thereby improved systemic, spinal and periphery morphine analgesia. CONCLUSIONS: Altogether, our results demonstrate that increased methylation of the MOR gene PP in DRG is required for the decreased morphine analgesia in neuropathic pain

Evaluation of X-Inactivation Status and Cytogenetic Stability of Human Dermal Fibroblasts after Long-Term Culture

Human primary fibroblasts are a popular type of somatic cells for the production of induced pluripotent stem (iPS) cells. Here we characterized biological properties of primary fibroblasts in terms of cell-growth rate, cytogenetic stability, and the number of inactive X chromosomes during long-term passaging. We produced eight lines of female human dermal fibroblasts (HDFs) and found normal karyotype and expected pattern of X chromosome inactivation (XCI) at low passages (Passage P1-5). However, four out of the eight HDF lines at high passage numbers (≥ P10) exhibited duplicated hallmarks of inactive X chromosome including two punctuate signals of histone H3 lysine 27 trimethylation (H3K27me3) and X inactive-specific transcript (XIST) RNA signals in approximately 8.5–18.5% of the cells. Our data suggest that the copy number of inactive X chromosomes in a subset of female HDF is increased by a two-fold. Consistently, DNA fluorescent in situ hybridization (FISH) identified 3-4 copies of X chromosomes in one nucleus in this subset of cells with two inactive Xs. We conclude that female HDF cultures exhibit a higher risk of genetic anomalies such as carrying an increased number of X chromosomes including both active and inactive X chromosomes at a high passage (≥ P10)

Neonatal resuscitation workshop for trainees in standardized medical residency training—a pilot practice in Shenzhen, China

BackgroundNeonatal resuscitation is an important skillset for clinicians attending deliveries. Accredited neonatal resuscitation training is not obligatory in most training centers of standardized medical residency programs before 2022 in China. We investigated the feasibility and effectiveness of neonatal resuscitation simulation training (neo-RST) in residents in Shenzhen, China.MethodsFour two-day neo-RST workshops were conducted in the University of Hong Kong-Shenzhen Hospital and Shenzhen Health Capacity Building and Continuing Education Center in 2020–2021. The workshops had Neonatal Resuscitation Program (NRP)® update, skill stations and simulation practice with debriefing. Each participant had the integrated skill station assessment (ISSA) at the end of workshop. Participants of workshops included residents of different disciplines and health care providers (HCPs) of neonatal and obstetrical departments. We compared demographic characteristics, neonatal resuscitation knowledge before training, ISSA overall and categorical scores on skill sets between residents and HCPs.ResultsIn 2020–2021, 4 neo-RST workshops were conducted with 48 residents and 48 HCPs. The residents group had less working experience, less prior experience in neo-RST and lower neonatal resuscitation knowledge scores than those of HCPs group. After the workshop, residents had higher overall ISSA score than that of HCPs group (90.2 ± 5.9 vs. 86.3 ± 6.6%, P = 0.003, respectively). There was no significant difference in the numbers of participants scored <80% in residents and HCPs group (3 [6.3%] vs. 7 [14.6%], respectively). Regarding the categorical scores, residents scored significantly higher in preparation, ventilation, crisis resource management and behavioral skills but lower in appropriate oxygen use, when compared with the HCPs.ConclusionNeo-RST for residents is feasible with promising short-term educational outcomes. Neo-RST could be implemented in standardized medical residency programs in China