Total Synthesis of (−)-Sessilifoliamide J

An efficient synthesis of the <i>Stemona</i> alkaloid (−)-sessilifoliamide J (<b>1</b>) in 12 steps and 7.7% overall yield from the known building block <b>8</b> is presented. The synthesis features the Corey lactonization reaction and a highly diastereoselective α-methylation reaction to build the spiro-lactone moiety