The APC Algorithm of Solving Large-Scale Linear Systems: A Generalized Analysis

A new algorithm called accelerated projection-based consensus (APC) has recently emerged as a promising approach to solve large-scale systems of linear equations in a distributed fashion. The algorithm adopts the federated architecture, and attracts increasing research interest; however, it's performance analysis is still incomplete, e.g., the error performance under noisy condition has not yet been investigated. In this paper, we focus on providing a generalized analysis by the use of the linear system theory, such that the error performance of the APC algorithm for solving linear systems in presence of additive noise can be clarified. We specifically provide a closed-form expression of the error of solution attained by the APC algorithm. Numerical results demonstrate the error performance of the APC algorithm, validating the presented analysis.Comment: 6 pages, 3 figure

A novel single nucleotide polymorphism within the NOD2 gene is associated with pulmonary tuberculosis in the Chinese Han, Uygur and Kazak populations

<p>Abstract</p> <p>Background</p> <p>The present study aimed to investigate the genetic polymorphisms in exon 4 of the <it>NOD2 </it>gene in tuberculosis patients and healthy controls, in order to clarify whether polymorphisms in the <it>NOD2 </it>gene is associated with tuberculosis.</p> <p>Methods</p> <p>A case-control study was performed on the Chinese Han, Uygur and Kazak populations. Exon 4 of the <it>NOD2 </it>gene was sequenced in 425 TB patients and 380 healthy controls to identify SNPs.</p> <p>Results</p> <p>The frequency of T/G genotypes for the Arg587Arg (CGT → CGG) single nucleotide polymorphism (SNP) in <it>NOD2 </it>was found to be significantly higher in the Uygur (34.9%) and Kazak (37.1%) populations than the Han population (18.6%). Also, the frequency of G/G genotypes for the Arg587Arg SNP was significantly higher in the Uyghur (8.3%) and Kazak (5.4%) populations than the Han population (0.9%). Meanwhile, no significant difference was found in the Arg587Arg polymorphism between the tuberculosis patients and healthy controls in the Uyghur and Kazak populations (<it>P </it>> 0.05) whereas, a significant difference was observed in the Arg587Arg polymorphism between the tuberculosis patients and healthy controls in the Han population (<it>P </it>< 0.01). The odd ratio of 2.16 (95% CI = 1.31-3.58; <it>P </it>< 0.01) indicated that the Arg587Arg SNP in <it>NOD2 </it>may be associated with susceptibility to tuberculosis in the Chinese Han population.</p> <p>Conclusions</p> <p>Our study is the first to demonstrate that the Arg587Arg SNP in <it>NOD2 </it>is a new possible risk factor for tuberculosis in the Chinese Han population, but not in the Uyghur and Kazak populations. Our results may reflect racial differences in genetic susceptibility to tuberculosis.</p

Amyloid-Like Aggregates of the Yeast Prion Protein Ure2 Enter Vertebrate Cells by Specific Endocytotic Pathways and Induce Apoptosis

BACKGROUND: A number of amyloid diseases involve deposition of extracellular protein aggregates, which are implicated in mechanisms of cell damage and death. However, the mechanisms involved remain poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Here we use the yeast prion protein Ure2 as a generic model to investigate how amyloid-like protein aggregates can enter mammalian cells and convey cytotoxicity. The effect of three different states of Ure2 protein (native dimer, protofibrils and mature fibrils) was tested on four mammalian cell lines (SH-SY5Y, MES23.5, HEK-293 and HeLa) when added extracellularly to the medium. Immunofluorescence using a polyclonal antibody against Ure2 showed that all three protein states could enter the four cell lines. In each case, protofibrils significantly inhibited the growth of the cells in a dose-dependent manner, fibrils showed less toxicity than protofibrils, while the native state had no effect on cell growth. This suggests that the structural differences between the three protein states lead to their different effects upon cells. Protofibrils of Ure2 increased membrane conductivity, altered calcium homeostasis, and ultimately induced apoptosis. The use of standard inhibitors suggested uptake into mammalian cells might occur via receptor-mediated endocytosis. In order to investigate this further, we used the chicken DT40 B cell line DKOR, which allows conditional expression of clathrin. Uptake into the DKOR cell-line was reduced when clathrin expression was repressed suggesting similarities between the mechanism of PrP uptake and the mechanism observed here for Ure2. CONCLUSIONS/SIGNIFICANCE: The results provide insight into the mechanisms by which amyloid aggregates may cause pathological effects in prion and amyloid diseases

Interpretation results used in the paper "Real-Time Dual-Para FWI-Inv of GPR Data Based on Robust Deep Learning"

The visualization code and dataset provided all the interpretation results within the article "Real-Time Dual-Para FWI-Inv of GPR Data Based on Robust Deep Learning"

Interpretation results used in the paper "Real-Time Dual-Para FWI-Inv of GPR Data Based on Robust Deep Learning"

The visualization code and dataset provided all the interpretation results within the article "Real-Time Dual-Para FWI-Inv of GPR Data Based on Robust Deep Learning"

The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase

Human plasma glutathione peroxidase (GSH-Px) is a distinct extracellular selenoenzyme that detoxifies hydroperoxides when used with GSH in high (mM) non-physiological concentrations. We have discovered that NADPH and human thioredoxin reductase (TR) by itself or with thioredoxin (Trx) are efficient electron donors to this human plasma peroxidase. Incubation of 0.05 microM TR with 0.25 microM GSH-Px, in a system free from GSH, resulted in reduction of t-butyl hydroperoxide. Addition of Trx, 2.5 and 5 microM, respectively, further increased the rate of the reaction. These data were obtained using an assay measuring the oxidation of NADPH. A direct assay demonstrated the formation of cumyl alcohol from cumene hydroperoxide in this GSH-independent peroxidase reaction. Incubation of 0.25 microM GSH-Px with a low concentration of GSH (10 microM), representing the upper level in plasma, plus excess glutathione reductase and NADPH did not result in any reduction of t-butyl hydroperoxide. However, after addition of 2.5 microM human glutaredoxin, a linear peroxidase reaction started. The results suggest that extracellular TR, Trx, or glutaredoxin are reductants for the selenium-dependent peroxidase rather than GSH

Extended x-ray absorption fine structure measurement of ramp compressed Ti using laser-irradiated metallic foil as x-ray source on SGIII prototype laser facility

Laser-irradiated metallic foils were considered as x-ray sources for extended x-ray absorption fine structure (EXAFS) measurements and confirmed by experiments on the SGIII prototype facility. The Au foils were irradiated by laser beams with a total energy of 2.77 kJ and full width at half maximum (FWHM) of 1 ns to create an x-ray source. The x-ray emission was spectrally smooth in the energy range of Ti EXAFS, the FWHM of Au foil x-ray radiation pulse in the energy range of 0.1–4000 eV was 0.99 ns, and the FWHM of x-ray pulse in the energy range of 5000–6000 eV was deduced to be 0.55 ns according to simulation results. A shaped laser pulse was designed to achieve the Ti sample’s laser-direct-driven ramp compression process. By creating a quasi-stable state lasting longer than 1 ns as the probing window during the compression process, the demand for temporal resolution was reduced. EXAFS spectra of compressed Ti in α and ω-phase were obtained and compared, and structural phase transition was verified by EXAFS pattern changes. The velocity of the back interface of the Ti sample was measured by the velocity interferometer system for any reflector, and the maximum of the deduced pressure in the middle of the Ti sample was 8.2 GPa, which is consistent with the α-ω phase transition

A Novel Model of Electromechanical Contactors for Predicting Dynamic Characteristics

To ensure the reliability of power supply, a dual power supply structure appears in the power distribution system. Power supply switching is a complex physical process. This paper presents a novel model of electromechanical contactors. This model can simulate the multi-physics process of power switching. This article completes the simulation framework for power switching through contactors for the first time. Among them, the structural topology for contactors is also proposed. On the basis of the novel structure topology, an equivalent magnetic circuit model is established to calculate the relationship between driving force, flux linkage, current, and displacement. Then, a co-simulation model is established between the above equations and Adams to obtain the speed characteristics and flight time of the contactor. Subsequently, through the use of Fluent and its secondary development, a magnetohydrodynamic model is established, and the above-mentioned velocity characteristics are imported into it to analyze the arcing characteristics of the contacts under the conditions of the transverse magnetic field and the insulating grid. The effectiveness of power switching is judged by comparing the flight time of the electromechanical model and the arcing time of the magnetohydrodynamic model. The prototype is manufactured and tested on the basis of simulation. Through experimental waveforms and high-speed photography, the accuracy of the simulation model and the practicability of the contactor are verified

Flame-Retardant Thermoplastic Polyether Ester/Aluminum Butylmethylphosphinate/Phenolphthalein Composites with Enhanced Mechanical Properties and Antidripping

Aluminum butylmethylphosphinate AiBMP as a flame retardant and phenolphthalein as a synergistic agent were applied in a thermoplastic polyester elastomer (TPEE)) in the current study. The thermal properties, flame retardancy, crystallization and mechanical properties of TPEE/AiMBP with or without phenolphthalein were investigated using various characterizations, including the limiting oxygen index (LOI), vertical burning test (UL 94), thermogravimetric analysis TG, differential scanning calorimetry, microcombustion calorimeter (MCC), scanning electron microscopy (SEM), and mechanical tests. The results revealed that AiBMP alone is an efficient flame retardant of TPEE. Adding 15 wt.% AiBMP increases the LOI value of TPEE from 20% to 36%. The formula TPEE-15 AiBMP passed the UL 94 V-0 rating with no dripping occurring. The MCC test shows that AiBMP depresses the heat release of TPEE. In comparison with pure TPEE, the heat release rate at peak temperature and the heat release capacity of TPEE-15AiBMP are reduced by 46.1% and 55.5%, respectively. With the phenolphthalein added, the formula TPEE/13AiBMP/2Ph shows a higher char yield at high temperatures (>600 °C), and the char layer is stronger and more condensed than TPEE-15AiBMP.The tensile strength and elongation at break values of TPEE-13AiBMP-2Ph are increased by 29.63% and 4.8% in comparison with TPEE-15AiBMP. The SEM morphology of the fracture surface of the sample shows that phenolphthalein acts as a plasticizer to improve the dispersion of AiBMP within the matrix. The good char charming ability of phenolphthalein itself and improved dispersion of AiBMP make the TPEE composites achieve both satisfying flame retardancy and high mechanical properties