Phosphorus(V)-Corrole: Synthesis, Spectroscopic Properties, Theoretical Calculations, and Potential Utility for <i>in Vivo</i> Applications in Living Cells

The synthesis and properties of phosphorus­(V) 5,10,15-tris­(4-methoxycarbonylphenyl)­corrole (<b>1</b>) have been investigated, and its potential utility for bioimaging applications in living cells has been explored. As would normally be anticipated for corrole complexes, the intensity of the Q­(0,0) bands of <b>1</b> is greater than those of comparable phosphorus­(V) tetraphenylporphyrins, but the Φ_F values (0.25 for <b>1</b>) are found to be comparable. A detailed analysis of the electronic structure of the complex was carried out by comparing electronic absorption and MCD spectral data to the results of TD-DFT calculations. The <i>meso</i>-aryl substituents, which enhance the lipophilicity of <b>1</b> and hence result in its localization in intracellular membranes during HeLa cell experiments, are predicted to result in a narrowing of the HOMO–LUMO gap and hence a red shift of the Q­(0,0) bands toward the optical window in biological tissues

Alkynyl BODIPY-Core Bridged Perylene Diimide Star-Shaped Nonfullerene Acceptors for Efficient Polymer Solar Cells

Two new star-shaped perylene diimide (PDI)-based small-molecule acceptors denoted as BDP-3PDI and BDP-4PDI with BODIPY derivatives as the core and PDI units as peripheral groups were designed and successfully synthesized, and their photophysical and electrochemical properties were studied. When paired with a compatible D–A polymer donor P(BTT-DPP), the polymer solar cells based on the bulk heterojunction active layer attained power conversion efficiencies (PCEs) of about 10.97 and 13.94% for BDP-3PDI and BDP-4PDI, respectively. The higher value of PCE for BDP-4PDI is mainly owing to the enhanced values of the fill factor and short circuit current as compared to BDP-3PDI and related to the more balanced charge transport and blocked charge recombination owing to the appropriate phase separation in the P(BTT-DPP):BDP-4PDI active layer as compared to P(BTT-DPP):BDP-3PDI

Surficial Oxidation of Phosphorus for Strengthening Interface Interaction and Enhancing Lithium-Storage Performance

By virtue of high theoretical capacity and appropriate lithiation potential, phosphorus is considered as a prospective next-generation anode material for lithium-ion batteries. However, there are some problems hampering its practical application, such as low ionic conductivity and serious volume expansion. Herein, we demonstrated an in situ preoxidation strategy to build a oxidation function layer at phosphorus particle. The oxide layer not only acted as a protective layer to prolong the storage time of phosphorus anode in air but also carbonized N-methyl pyrrolidone and poly (vinylidene fluoride), strengthening the interfacial interaction between phosphorus particles and binder. The oxide layer further induced the formation of a stable solid electrolyte interface with high lithium-ion conductivity. The oxidized P-CNT maintained high specific capacity of 1306 mAh g–1 and 89% capacity after 100 cycles, much higher than that of pristine P-CNT (17.1%). The strategy of in situ oxidation is facile and conducive to the practical application of phosphorus-based anodes

Additional file 4: of Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer

Figure S2. Comparison of biological pathway between IBC and non-IBC in four subgroups. (a) The percentage of samples with alteration on 10 biological pathways in the TNBC subgroup; (b) the percentage of samples with alteration on 10 biological pathways in the HR–/HER2+ subgroup; (c) the percentage of samples with alteration on 10 biological pathways in the HR+/HER2– subgroup; (d) the percentage of samples with alteration on 10 biological pathways in the HR+/HER2+ subgroup. The gray bars indicate non-IBC, the black bars indicate IBC; *p < 0.05, **p < 0.01, ***p < 0.001. (PDF 41 kb

Additional file 1: of Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer

Table S1. Pathological and clinical characteristics of non-IBC cohorts. (PDF 169 kb

Additional file 2: of Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer

Table S2. BreastCurie gene panel for targeted NGS. (PDF 411 kb

Additional file 6: of Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer

Figure S4. MFS curves stratified by PIK3CA mutation in three subgroups of IBC patients. (a) Kaplan-Meier estimates of MFS according to PIK3CA mutations in patients of the HR– subgroup, (b) Kaplan-Meier estimates of MFS according to PIK3CA mutations in patients of the HER2+ subgroup, (c) Kaplan-Meier estimates of MFS according to PIK3CA mutations in patients of the HR+ subgroup. (PDF 42 kb

Additional file 5: of Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer

Figure S3. DNA copy number alterations in the IBC cohort. The genes with DNA copy number alterations are grouped along the x axis, the percentage of samples with DNA copy number alterations shown on the y axis, DNA amplifications are indicated by black bars above the x axis, and DNA deletions are indicated by gray bars below the x axis. (PDF 164 kb

Additional file 3: of Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer

Figure S1. Comparison of somatic mutation frequency between IBC and non-IBC in four subgroups. (a) The percentage of samples with somatic mutation in the TNBC subgroup; (b) the percentage of samples with somatic mutation in the HR–/HER2+ subgroup; (c) the percentage of samples with somatic mutation in the HR+/HER2– subgroup; (d) the percentage of samples with somatic mutation in the HR+/HER2+ subgroup. The gray bars indicate non-IBC, the black bars indicate IBC; *p < 0.05, **p < 0.01, ***p < 0.001. (PDF 52 kb

Neo-N-confused Phlorins and Phlorinone: Rational Synthesis and Tunable Properties

By the acid-catalyzed [2 + 2] condensation, an unprecedented neo-N-confused phlorin (neo-NCphlorin <b>1</b>) was successfully synthesized. By treating 1 with <i>N</i>-chlorosuccinimide, the corresponding chloro-substituted neo-NCphlorin (1-Cl) was obtained. The oxidization of 1 with FeCl₃ afforded the neo-N-confused phlorinone (neo-NCphlorinone <b>2</b>), which bears a relatively coplanar conformation, different from the highly distorted ones observed for <b>1</b> and <b>1-Cl</b>. Notably, <b>2</b> shows striking long-wavelength absorption beyond 1300 nm upon addition of TBAF