Electrochemical Reductive Functionalization of Alkenes with Deuterochloroform as a One-Carbon Deuteration Block

Deuterochloroform is the most common organic deuterated solvent. However, the synthetic chemistry of deuterochloroform has been marginally explored because of its intrinsic limitations, including elimination and scrambling. In this work, an electrochemical protocol was developed to use deuterochloroform as a one-carbon deuteration block in the cyclopropanation and hydrochloromethylation of alkenes. By employing different reaction conditions, the chemoselectivity could be regulated to give divergent products. Typically, deuterium incorporation above 93% to 99% could be achieved

Enantioselective Total Synthesis of (+)-Lithospermic Acid

An enantioselective synthesis of (+)-lithospermic acid, a potent anti-HIV agent, has been accomplished in a convergent manner in nine steps. The synthesis features an enantioselective intramolecular oxa-Michael addition catalyzed by a quinidine derivative, a hypervalent iodine-mediated rearrangement of chromanone to dihydrobenzofuran, an enantioselective α-oxyamination, and an intermolecular C–H olefination

Scandium-Catalyzed Electrochemical Synthesis of α‑Pyridinyl Tertiary Amino Acids and Esters

α-Pyridyl tertiary amino acids have potential pharmaceutical applications because of their structural features. However, their synthesis is still highly limited. Herein, we report a straightforward approach for the electrochemical synthesis of tertiary α-substituted amino acid derivatives via three-component reductive coupling. Using gaseous ammonia as both the N and H source, the α-keto ester reacts directly with 4-CN-pyridine. The application of scandium catalysis is the key for achieving chemoselectivity among various side reaction pathways

sj-tif-1-cpc-10.1177_10556656221136171 - Supplemental material for A Novel Rat Model for Muscle Regeneration and Fibrosis Studies in Surgical Lip Repair

Supplemental material, sj-tif-1-cpc-10.1177_10556656221136171 for A Novel Rat Model for Muscle Regeneration and Fibrosis Studies in Surgical Lip Repair by Jinggui Li, Yixuan Huang, Jingtao Li, Bing Shi and Xu Cheng in The Cleft Palate-Craniofacial Journal</p

The deformation of the skin envelope consequent to different force loadings.

<p>(A) F1 alone; (B) F2 alone; (C) F3 alone; (D) F1 plus F2; (E) F1 plus F3; (F) F1, F2 and F3 at the same time. The length and direction of the arrow represented the value and direction of the deformation respectively.</p

CAD model construction and vectors of force loadings.

<p>(A) Demonstration of a typical unilateral cleft lip nasal deformity. (B) Fetal specimen used for micro-MRI scanning. (C, D) The CAD model composed of both cartilage framework and skin envelope. (E, F) The directions of forces loaded on the alar cartilage.</p

Micro-MRI imaging reconstruction.

<p>(A, B, C) Micro-MRI imaging of the fetal specimen. Red arrows indicated the position of cartilages, including the alar cartilages (AC), the upper lateral cartilages (ULC) and the nasal septum (NS). (D) Three dimensional reconstruction of the micro-MRI imaging.</p

Intermolecular C–H Quaternary Alkylation of Aniline Derivatives Induced by Visible-Light Photoredox Catalysis

The intermolecular direct C–H alkylation of aniline derivatives with α-bromo ketones to build a quaternary carbon center was reported with a visible-light catalysis procedure. The reaction covers a variety of functional groups with good to excellent yields. A regioselectivity favoring the <i>ortho</i> position for the amine group was observed and investigated with Fukui indices and spectral methods

Supplement 1. Data Quality Pedigree Calculator.

<h2>File List</h2><ul> <li><a href="pedigree_manual.htm">pedigree_manual</a></li> <li><a href="pedigree_notes.htm">pedigree_notes</a></li> <li><a href="pedigree.xls">pedigree.xls</a></li> </ul><h2>Description</h2><p>This supplement contains a Microsoft Excel^® 97 for Windows^®workbook file, pedigree.xls, that supports the calculation of data quality pedigrees using the Microsoft Excel Visual Basic program referenced in Ellis et al. (2000).  This file includes the pedigree calculation program, and can be used to enter and calculate pedigrees for variables in standardized worksheets.  The file also includes an interactive demonstration using example worksheets to demonstrate the use of the pedigree calculation program and a blank standardized worksheet for entering and calculating pedigrees of one's own.  An html document, <a href="pedigree_manual.htm">pedigree_manual</a>, provides a manual for the use of the pedigree calculation program and demonstration worksheets in pedigree.xls.  We recommend printing the manual before using pedigree.xls so that it can be used while pedigree.xls occupies the entire computer screen.  Additional notes on the algorithms used by the pedigree calculation program in pedigree.xls are provided in an html document, <a href="pedigree_notes.htm">pedigree_notes</a>. </p> <p>The pedigree.xls file is designed to run on computers with MS Windows^® 95, 98, NT 4.0 or higher, and Excel 97, 2000, or higher.  It should also run on Macintosh^® computers with Microsoft Excel 98, but this has not been tested.  The demonstration works best on computers with screen settings of 1024 × 768 or greater and color is required.  When opening pedigree.xls in Excel, make sure to enable macros if queried about this.  To calculate variables using probability distributions (PDFs) and Monte Carlo simulation, @RISK^® software for Excel (Palisade Corporation) must be installed.  However, this demonstration assumes that @RISK is not installed, and that variables will be represented by their mean values.</p

The TD and EQV at major landmarks on the skin envelope.

<p>(A) Path one was defined by the alar bases at both sides (Landmarks one, five), the alar domes at both sides (Landmark two, four) and the nasal tip (Landmark three); (a) Path two was defined by the columella base (Landmark one), the nasal tip (Landmark two), the dorsum (Landmark three) and the nasal radix (Landmark four); (B, C, D, E, F, G) The vectors of TD on Path one; (b, c, d, e, f, g) The vectors of TD on Path two; (H) The TD on Path one; (I) The EQV on Path one; (h) The TD on Path two; (i) The EQV on Path two.</p