633 research outputs found

    Research on the Relationship Between Perceived Social Support and Subjective Well Being of Left Behind Children

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    In this study, “perceived social support scale (SPSS)”, “happiness” and “emotional index scale: positive emotion, negative emotion and emotional balance” as the measurement tool of left-behind children understand the relationship between social support and subjective well-being were studied. The results showed that: (a) left-behind children and non left-behind children perceived social support have significant differences, which left the perceived social support level of children is significantly lower than the non left-behind children; (b) left-behind children and non left-behind children in emotional well-being, life satisfaction index, there is a significant difference, performance for the left-behind children in happiness and emotion index, life satisfaction scores were significantly lower than those of non left-behind children; (c) left behind children between perceived social support and subjective well-being are positively related. In particular, friends and family support the greatest impact on happiness. Through the regression analysis, the results showed that friends and family support had a significant predictive effect on the well-being of left behind children

    A Relation Research on the Self-Worth and Personality of Rural Junior High School Left-Behind Students

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    Using two questionnaires, the research investigates the self-worth and the personality of 303 rural Junior High School left-behind students and 365 Left-behind Junior High School students. The results show that: (a) The development level of self-worth of rural Left-behind Junior High School students is less than normal left-behind students in N scale and SS1.(b)There is higher of grade one than grade three in GI. (c) There is significant of SI3 and P scale and N scale in gender. (d) There is significant correlation between personality and self-worth for rural Left-behind Junior High School students. (e) Personality traits could predict most dimensions of self-worth

    Epidemiology of Alzheimer’s Disease

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    Separation and purification of the bovine milk fat globule membrane protein and its effect on improvement of C2C12 mouse skeletal muscle cell proliferation

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    A novel method to improve the proliferation activity of C2C12 cells by the bovine milk fat globule membrane (MFGM) protein was established in this study. The MFGM protein was extracted and isolated into 4 fractions using an electric cream separator, and purified by a cellulose DEAE-52 column. Fraction 2 accounted for 57.8% of the total MFGM protein, and was used in the following study. The MTT assay showed that it induced cell proliferation activity, increased the cell survival rate and the cell number using flow cytometry and fluorescence microscopy analysis. There were only subtle changes in the morphology as observed using confocal scanning laser microscopy, but the number of mitochondria was significantly increased as observed using transmission electron microscopy analysis. Furthermore, the mRNA expression of MyoD, cyclin D1, p70S6K and mTOR was up-regulated as determined utilizing the quantitative real-time PCR assay, and the activation of Akt and mTOR phosphorylation was up regulated as determined using the Western blot assay. The main protein in fraction 2, assayed by 1-D gel electrophoresis and MALDI TOF-TOF, was identified as milk fat globule-EGF factor 8, the content was 65.6% of the total protein in fraction 2. The results elucidate a new molecular mechanism of the MFGM protein fraction 2: the activation of the Akt signal pathway in promoting cell proliferation

    What impacts the helpfulness of online multidimensional reviews? A perspective from cross-attribute rating and ranking Inconsistency

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    This paper proposes investigations of the effects of information inconsistency, particularly ranking inconsistency, on the review helpfulness in a multidimensional rating system, based on information diagnosticity and attribution theory. The insight findings of this paper are: (a) The product cross-attribute dispersion has a significant negative impact on review helpfulness, while the overall attribute ranking consistency and the ranking consistency of the product’s best prominent attribute positively impact review helpfulness. (b) The product cross-attribute dispersion negatively impacts the review helpfulness for non-luxury products but it positively impacts that for luxury products, while the cross-attribute rating difference of a single review positively impacts it helpfulness only if the product is non-luxury. (c) The overall attribute ranking consistency significantly impacts the review helpfulness only for luxury products, whereas the ranking consistency of the product\u27s best and worst prominent attributes impact the review helpfulness only for non-luxury products

    Alzheimer’s Disease: A Clinical Perspective

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    Production cotonnière chinoise : forces et faiblesses d'une intégration et d'une adaptation à l'économie de marché

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    La Chine est le premier pays producteur de coton dans le monde mais sa forte consommation la place en position d'importateur structurel. La production chinoise est issue d'une agriculture familiale, avec une sole cotonnière d'environ 0,3 ha par exploitation, dont le niveau d'intensification lui permet d'atteindre l'un des rendements les plus élevés au monde. C'est le résultat d'une volonté politique pendant près d'un demi-siècle, à partir d'une recherche dynamique et d'un soutien aux producteurs à travers subvention aux intrants et garantie de prix d'achat. Dès la veille de l'entrée de la Chine à l'OMC, il n'y a plus de subvention directe aux producteurs de coton et la production cotonnière se poursuit dans une filière de plus en plus libéralisée. Le mode d'intensification persiste en raison du développement du marché des intrants; l'utilisation de variétés de coton génétiquement modifié (CGM) s'inscrit comme une nouvelle étape de l'intensification. L'absence de velléité de coordination pour mener des actions collectives pénalise cependant la rentabilité de la production cotonnière et peut hypothéquer la durabilité de l'utilisation du CGM. Les fortes fluctuations de prix découragent les paysans à s'engager dans une spécialisation cotonnière accrue et elles se répercutent dans une production instable. La Chine devrait rester importatrice nette de coton, surtout dans un contexte de déclin de l'activité agricole.Chine; coton; agriculture familiale; libéralisation; OGM

    Milk fat globule membrane protein promotes C2C12 cell proliferation through the PI3K/Akt signaling pathway

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    Milk fat globule membrane (MFGM) protein is known to have several health benefits, including an anti-sarcopenia effect; however, its mechanism is unclear. The aim of this study was to investigate the potential mechanism of action of the MFGM protein. The MFGM protein was extracted and separated into 4 fractions, and Fraction 2 (57 % of total MFGM) demonstrated the greatest effect on C2C12 cell proliferation. Milk fat globule-EGF factor 8 (MFG-E8) accounted for 82.35 % of the MFGM protein. The effects of whole Fraction 2 (100 μg/mL, 200 μg/mL and 300 μg/mL) on cell proliferation and morphology were measured. Using qRT-PCR or a Western blot assay, several regulatory factors, e.g., PI3K P85α, p-pI3K p85α (Tyr 508), Akt, p-Akt (Ser 473), mTOR and p-mTOR (Ser 2448), were measured in cells incubated with 200 μg/mL of Fraction 2 with or without wortmannin. The results demonstrated that Fraction 2 induced C2C12 cell proliferation in a dose-dependent manner, upregulated the mRNA expression of mTOR and p70S6K, and activated PI3K, Akt, mTOR and P70S6K phosphorylation; however, Fraction 2 inhibited FOXO3a and 4E-BP. The results demonstrate that the MFGM protein, predominantly MFG-E8, promotes cell proliferation through the PI3K/Akt/mTOR signaling pathway. This study elucidated the molecular mechanism of the MFGM protein, primarily MFG-E8, in promoting C2C12 cell proliferation via the PI3K/Akt/mTOR/P70S6K signal pathway
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