15,316 research outputs found
On the Convergence of (Stochastic) Gradient Descent with Extrapolation for Non-Convex Optimization
Extrapolation is a well-known technique for solving convex optimization and
variational inequalities and recently attracts some attention for non-convex
optimization. Several recent works have empirically shown its success in some
machine learning tasks. However, it has not been analyzed for non-convex
minimization and there still remains a gap between the theory and the practice.
In this paper, we analyze gradient descent and stochastic gradient descent with
extrapolation for finding an approximate first-order stationary point in smooth
non-convex optimization problems. Our convergence upper bounds show that the
algorithms with extrapolation can be accelerated than without extrapolation
Evidence of the side jump mechanism in the anomalous Hall effect in paramagnets
Persistent confusion has existed between the intrinsic (Berry curvature) and
the side jump mechanisms of anomalous Hall effect (AHE) in ferromagnets. We
provide unambiguous identification of the side jump mechanism, in addition to
the skew scattering contribution in epitaxial paramagnetic NiCu
thin films, in which the intrinsic contribution is by definition excluded.
Furthermore, the temperature dependence of the AHE further reveals that the
side jump mechanism is dominated by the elastic scattering
Half Metallic Bilayer Graphene
Charge neutral bilayer graphene has a gapped ground state as transport
experiments demonstrate. One of the plausible such ground states is layered
antiferromagnetic spin density wave (LAF) state, where the spins in top and
bottom layers have same magnitude with opposite directions. We propose that
lightly charged bilayer graphene in an electric field perpendicular to the
graphene plane may be a half metal as a consequence of the inversion and
particle-hole symmetry broken in the LAF state. We show this explicitly by
using a mean field theory on a 2-layer Hubbard model for the bilayer graphene.Comment: 4+ pages, 4 figure
4-{(Z)-(sec-Butylamino)(phenyl)methylene}-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
In the title compound, C21H23N3O, the dihedral angles formed by the pyrazolone ring with two phenyl rings are 10.38 (8) and 76.94 (6)°. The sec-butylamino group is disordered over two positions, with refined site-occupancy factors of 0.730 (4) and 0.270 (4). The compound could potentially be ligand stabilized in the solid state in a keto–enamine tautomeric form. The amine functionality is involved in an intramolecular N—H⋯O hydrogen bond, while weak intermolecular C—H⋯O and C—H⋯N hydrogen bonds participate in the formation of the crystal structure
Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells.
Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors. We discovered an endoglin (CD105)-expressing subpopulation in human RCC xenografts and patient samples with a greater capability to form spheres in vitro and tumors in mice at low dilutions than parental cells. Knockdown of CD105 by short hairpin RNA and CRISPR/cas9 reduced stemness markers and sphere-formation ability while accelerating senescence in vitro. Importantly, downregulation of CD105 significantly decreased the tumorigenicity and gemcitabine resistance. This loss of stem-like properties can be rescued by CDA, MYC, or NANOG, and CDA might act as a demethylase maintaining MYC and NANOG. In this study, we showed that Endoglin (CD105) expression not only demarcates a cancer stem cell subpopulation but also confers self-renewal ability and contributes to chemoresistance in RCC
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