624 research outputs found

    Electroluminescent ceramics excited by low electrical field

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    Strong green-light emission occurs in Eu:SrAl₂O₄ ceramics and Eu:SrAl₂O₄ /poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) composites when excited by a lower dc or ac voltage. That emission is caused by strong electric-mechanic-optic interaction. The composite shows stronger luminescent emission intensity in comparison to similar ceramics because of an enhanced piezoelectric effect from P(VDF-TrFE)—a typical piezoelectric polymer

    A combined diffraction (XRD, electron and neutron) and dielectric study of Na3MoO3F3

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    For the dielectric measurements, Na3MoO3F3 ceramics were cut and polished down to a disc with a thickness of 0.5 mm and a diameter of 4.79 mm. Gold electrodes were then sputtered onto both surfaces of the sample. Its polarisation hysteresis loop was characterised by a ferro- and piezo-electric measuring system (TA Analyser 2000, aixACT). The temperature dependence of the dielectric constant and the dissipation factor of Na3MoO3F3 was investigated at 10KHz by a high precision LCR meter (3522, Hioki) between room temperature and 180oC using a scan rate of 5oC/min

    Experimental Study on Unconfined Compressive Strength of Basalt Fiber Reinforced Clay Soil

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    In order to study the mechanism and effect of basalt fiber reinforced clay soil, a series of unconfined compressive strength tests conducted on clay soil reinforced with basalt fiber have been performed under the condition of optimum water content and maximum dry density. Both the content and length of basalt fiber are considered in this paper. When the effect of content is studied, the 12 mm long fibers are dispersed into clay soil at different contents of 0.05%, 0.1%, 0.15%, 0.20%, 0.25%, 0.30%, and 0.35%. When the effect of length is researched, different lengths of basalt fibers with 4 mm, 8 mm, 12 mm, and 15 mm are put into soil at the same content of 0.05%. Experimental results show that basalt fiber can effectively improve the UCS of clay soil. And the best content and length are 0.25% and 12 mm, respectively. The results also show that the basalt fiber reinforced clay soil has the “poststrong” characteristic. About the reinforcement mechanism, the fiber and soil column-net model is proposed in this paper. Based on this model and SEM images, the effect of fiber content and length is related to the change of fiber-soil column and formation of effective fiber-soil net

    Interferon-induced transmembrane protein 3 in the hippocampus: a potential novel target for the therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy

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    ObjectiveThis study aims to explore whether interferon-induced transmembrane protein 3 (IFITM3) is involved in recombinant human brain natriuretic peptide (rhBNP)-mediated effects on sepsis-induced cognitive dysfunction in mice.MethodsThe cellular localization and expression level of IFITM3 in the hippocampus were detected. The IFITM3 overexpression was achieved using an intracranial stereotactic system to inject an adeno-associated virus into the hippocampal CA1 region of mice. Field experiments, an elevated plus maze, and conditioned fear memory tests assessed the cognitive impairment in rhBNP-treated septic mice. Finally, in the hippocampus of septic mice, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) staining and Immunoblot were used to detect changes in the protein expression of cleaved Caspase-8 and cleaved Caspase-3 in apoptosis-related pathways, and toll-like receptor 4 (TLR4) and nuclear factor ÎşB (NF-ÎşB) p65 in inflammatory pathways.ResultsFourteen days after cecal ligation and puncture (CLP) surgery, IFITM3 localized in the plasma membrane and cytoplasm of the astrocytes in the hippocampus of septic mice, partially attached to the perivascular and neuronal surfaces, but not expressed in the microglia. The expression of IFITM3 was increased in the astrocytes and neurons in the hippocampus of septic mice, which was selectively inhibited by the administration of rhBNP. Overexpression of IFITM3 resulted in elevated anxiety levels and long-term learning and memory dysfunction, completely abolished the therapeutic effect of rhBNP on cognitive impairment in septic mice, and induced an increase in the number of neuronal apoptosis in the hippocampal CA1 region. The expression levels of cleaved Caspase-3 and cleaved Caspase-8 proteins were significantly increased in the hippocampus, but the expression levels of TLR4 and NF-ÎşB p65 were not increased.ConclusionThe activation of IFITM3 may be a potential new target for treating sepsis-associated encephalopathy (SAE), and it may be one of the key anti-apoptotic mechanisms in rhBNP exerting its therapeutic effect, providing new insight into the clinical treatment of SAE patients
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