Transcriptional Regulation by ERR and Its Role in NAFLD Pathogenesis

Members of estrogen-related receptors (ERRs) are orphan nuclear receptors (NRs) that play primary roles in mitochondrial biogenesis and bioenergetics. The ERRs regulate a range of cellular functions, including oxidative phosphorylation (OXPHOS) as well as glucose and lipid metabolism. ERRs are considered important targets for the treatment of metabolic diseases, particularly type II diabetes (T2D), insulin resistance (IR) and obesity. In this review, we will overview the transcriptional network regulated by the members of ERR transcriptional factors and elaborate on the regulation of ERR via its binding to PGC-1α, the primary co-activator of ERR as well as post-translational regulation of ERRs by upstream kinase signals. Recent development in ERR’s cellular function has identified lipid metabolism/lipogenesis as a process that ERR regulates, and this function significantly impacts metabolic syndrome. Here, we will focus on their roles in lipid metabolic regulation and discuss the in vivo functions of ERRs in the development of non-alcoholic fatty liver disease (NAFLD), a comorbid metabolic syndrome concurrent with T2D, IR as well as obesity. Finally, we will explore ERRs as potential therapeutic targets by discussing the ligands that serve as antagonist/agonists for ERRs as well as efforts that target DNA binding of ERR as a transcriptional factor

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, molecules of critical importance to immunity. Here we show, using a genome-wide CRISPR knockout screen, that ubiquitin-like protein 3 (UBL3) is a necessary component of ubiquitination-mediated trafficking of these molecules in mice and in humans. Ubl3-deficient mice have elevated MHC II and CD86 expression on the surface of professional and atypical antigen presenting cells. UBL3 also regulates MHC II and CD86 in human dendritic cells (DCs) and macrophages. UBL3 impacts ubiquitination of MARCH1 substrates, a mechanism that requires UBL3 plasma membrane anchoring via prenylation. Loss of UBL3 alters adaptive immunity with impaired development of thymic regulatory T cells, loss of conventional type 1 DCs, increased number of trogocytic marginal zone B cells, and defective in vivo MHC II and MHC I antigen presentation. In summary, we identify UBL3 as a conserved, critical factor in MARCH1-mediated ubiquitination with important roles in immune responses

COVID-19 pneumonia with night sweat as the first symptom: DOI: 10.14800/ics.463

A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were successively reported in Wuhan, China. The major presentations of patients are fever, fatigue, and dry cough. No cases have been reported with night sweats as the first symptom. This article present a case which diagnosed with COVID-19 pneumonia with night sweats as the first symptom.  Chest CT showed patches of ground-glass opacity, qRT-PCR of SARS-CoV-2 were positive. After treatment, the patient did not present with night sweats again. A recheck of the chest CT showed that the ground-glass opacity was completely absorbed and the SARS-CoV-2 nucleic acid test was negative. This case suggests that night sweats might be the first and major symptom of COVID-19 pneumonia

Data-Sharing Work of the World Data Center for Geophysics, Beijing

The World Data Center (WDC) for Geophysics, Beijing, was founded in 1988. Supported by The Chinese Academy of Science and The Ministry of Science and Technology, our center has made much progress in recent years. The center has not only established the database to restore data which contain heat flow data, geomagnetic data, gravity data, etc. but also put them on the Internet (http://gp.wdc.cn) to provide free data service. The center has expended a great deal of effort to rescue the magnetograms observed 100 years ago by the Sheshan Observatory, the earliest geomagnetic observatory in China. The geophysics data of our center are abundant, and the way to get the data and information from the website is very simple and easily obtainable. In the future, the center will edit more data and construct a strong, convenient database in order to provide the better service to users