409 research outputs found

    Measurements of the Hubble constant from combinations of supernovae and radio quasars

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    In this letter, we propose an improved cosmological model independent method of determining the value of the Hubble constant H0H_0. The method uses unanchored luminosity distances H0dL(z)H_0d_L(z) from SN Ia Pantheon data combined with angular diameter distances dA(z)d_A(z) from a sample of intermediate luminosity radio quasars calibrated as standard rulers. The distance duality relation between dL(z)d_L(z) and dA(z)d_A(z), which is robust and independent of any cosmological model, allows to disentangle H0H_0 from such combination. However, the number of redshift matched quasars and SN Ia pairs is small (37 data-points). Hence, we take an advantage from the Artificial Neural Network (ANN) method to recover the dA(z)d_A(z) relation from a network trained on full 120 radio quasar sample. In this case, the result is unambiguously consistent with values of H0H_0 obtained from local probes by SH0ES and H0LiCOW collaborations. Three statistical summary measures: weighted mean H~0=73.51(±0.67) km s−1 Mpc−1\widetilde{H}_0=73.51(\pm0.67) {~km~s^{-1}~Mpc^{-1}}, median Med(H0)=74.71(±4.08) km s−1 Mpc−1Med(H_0)=74.71(\pm4.08) {~km~s^{-1}~Mpc^{-1}} and MCMC simulated posterior distribution H0=73.52−0.68+0.66 km s−1 Mpc−1H_0=73.52^{+0.66}_{-0.68} {~km~s^{-1}~Mpc^{-1}} are fully consistent with each other and the precision reached 1%1\% level. This is encouraging for the future applications of our method. Because individual measurements of H0H_0 are related to different redshifts spanning the range z=0.5−2.0z=0.5 - 2.0, we take advantage of this fact to check if there is any noticeable trend in H0H_0 measurements with redshift of objects used for this purpose. However, our result is that the data we used strongly support the lack of such systematic effects.Comment: 20 pages, 5 figures, accepted for publication in Physics Letters

    Trend of myopia through different interventions from 2010 to 2050: Findings from Eastern Chinese student surveillance study

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    PurposeFirst, to investigate the utilization rate and effect of proven myopic interventions. Second, to predict the prevalence of myopia and high myopia, as well as Years Lived with Disability (YLD) caused by an uncorrected refractive error in children and teens in Eastern China from 2010 to 2050 under different interventions.Methods(1) The surveillance of common diseases among children and adolescents in Jiangsu Province from 2010 to 2021 provides the database for myopia screening and intervention utilization surveys. (2) The National Bureau of Statistics and the Global Burden of Disease Study 2016 (GBD2016) are the foundation for the estimated myopes and YLD. (3) A systematic review provides the strong or weak impact of intervention in the prediction model. (4) The trend of screening myopia from 2010 to 2050 under various treatments is predicted using a GM (1,1) model.ResultsBy the year 2050, myopia is expected to affect 8,568,305 (7–12 years old) and 15,766,863 (13–18 years old) children and adolescents, respectively (95% CI: 8,398,977–8,737,633). The utilization prevalence of myopia-proven interventions for myopic children included outdoor activities, orthokeratology lenses, atropine treatment, contact lenses, frame glasses, and eye exercises, with respective rates of 31.9–33.1, 2.1–2.3, 6.0–7.5, 2.2–2.7, 60.4–62.2, and 64.7–72.5%. All interventions have substantial effects on myopia after parental myopia and behavior pattern adjustment, including physical activity, near work, dietary pattern, and sleep. Under strong intervention, the estimated reduced myopia prevalence by the year 2050 is 1,259,086 (95% CI: 1,089,758–1,428,414) for children aged 7–12, and 584,785 (95% CI: 562,748–606,823) for children aged 13–18, respectively.ConclusionAmong myopic Chinese children and adolescents, the use rates and effects of proven myopia interventions vary. Under the present intervention strategy, the prevalence of myopia and high myopia will increase from 2010 to 2050. The overall number of myopic people can be greatly decreased by implementing timely, steady, comprehensive interventions

    Phloretin Attenuates Listeria monocytogenes Virulence Both In vitro and In vivo by Simultaneously Targeting Listeriolysin O and Sortase A

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    The critical roles of sortase A (SrtA) and listeriolysin O (LLO) in Listeria monocytogenes pathogenicity render these two virulence factors as ideal targets for the development of anti-virulence agents against L. monocytogenes infection. Additionally, the structures of SrtA and LLO are highly conserved among the members of sortase enzyme family and cholesterol dependent toxin family. Here, phloretin, a natural polyphenolic compound derived from apples and pears that has little anti-L. monocytogenes activity, was identified to simultaneously inhibit LLO expression and neutralize SrtA catalytic activity. Phloretin neutralized SrtA activity by causing a conformational change in the protein's active pocket, which prevented engagement with its substrate. Treatment with phloretin simultaneously reduced L. monocytogenes invasion into host cells and blocked the escape of vacuole-entrapped L. monocytogenes into cytoplasm. Further, L. monocytogenes-infected mice that received phloretin showed lower mortality, decreased bacterial burden and reduced pathological injury. Our results demonstrate that phloretin is a promising anti-infective therapeutic for infections caused by L. monocytogenes due to its simultaneous targeting of SrtA and LLO, which may result in fewer side effects than those caused by other antibiotics

    Os sistemas de informação como ferramenta de controle na gestão de estacionamentos em shoppings

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    Orientador : Luiz Carlos SouzaMonografia (especialização) - Universidade Federal do Paraná, Setor de Ciências Sociais Aplicadas. Curso de Especialização em Contabilidade e FinançasInclui referênciasResumo : A pesquisa em tela trata da analise das ferramentas utilizadas pela controladoria na gestão de estacionamentos em shoppings centers, visando demonstrar os tipos de relatórios gerados pelos sistemas de gerenciamento desenvolvidos por empresas especializadas em software focado em tecnologias de gestão em estacionamentos. Observado que atualmente, grande parte dos gestores da área de gestão direcionada a estacionamento, tem dificuldade de desenvolver fatores de informação ao qual forneça dados comparativos e financeiros em que os gestores consigam elaborar projeções e estratégias visando maior retorno financeiro e amenizando as despesas operacionais. A pesquisa em questão trata também da importância da controladoria e os setores envolvidos e interligados, buscando cada vez mais ampliar o índice de informações que envolvem a operacionalidade, as metas a ser atingidas pela gestão do negócio
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