Cationic Pd(II)-Catalyzed Highly Enantioselective Arylative Cyclization of Alkyne-Tethered Enals or Enones Initiated by Carbopalladation of Alkynes with Arylboronic Acids

Cationic Pd(II)-catalyzed enantioselective arylative cyclization of alkyne-tethered enals or enones initiated by carbopalladation of alkynes was developed without the necessity of a redox system

Synthesis of Cyclohexane-Fused Isocoumarins via Cationic Palladium(II)-Catalyzed Cascade Cyclization Reaction of Alkyne-Tethered Carbonyl Compounds Initiated by Intramolecular Oxypalladation of Ester-Substituted Aryl Alkynes

A cationic Pd­(II)-catalyzed cascade cyclization reaction of alkyne-tethered carbonyl compounds was developed. This reaction is initiated by intramolecular oxypalladation of alkynes with an ester group followed by 1,2-addition of the formed C–Pd­(II) bond to the carbonyl group, providing a highly efficient method for the synthesis of cyclohexane-fused isocoumarins

Synthesis of Cyclohexane-Fused Isocoumarins via Cationic Palladium(II)-Catalyzed Cascade Cyclization Reaction of Alkyne-Tethered Carbonyl Compounds Initiated by Intramolecular Oxypalladation of Ester-Substituted Aryl Alkynes

A cationic Pd­(II)-catalyzed cascade cyclization reaction of alkyne-tethered carbonyl compounds was developed. This reaction is initiated by intramolecular oxypalladation of alkynes with an ester group followed by 1,2-addition of the formed C–Pd­(II) bond to the carbonyl group, providing a highly efficient method for the synthesis of cyclohexane-fused isocoumarins

Atom-Economic Synthesis of Pentaleno[2,1‑<i>b</i>]indoles via Tandem Cyclization of Alkynones Initiated by Aminopalladation

An atom-economic Pd­(OAc)₂-catalyzed tandem cyclization of alkynones to synthesize pentaleno­[2,1-<i>b</i>]­indoles was developed efficiently. In the formed tetracyclic indole framework, two neighboring stereocenters, one being all-carbon quaternary, are being constructed in a single process with excellent diastereoselectivity. This reaction was initiated by aminopalladation of alkynes and quenched by addition to the intramolecular carbonyl groups

Synthesis of Indole-Substituted Indanones via Palladium(II)-Catalyzed Tandem Reaction of <i>ortho</i>-Electron-Deficient Alkynyl-Substituted Aryl Aldehydes with Indoles

A Pd­(OAc)₂-catalyzed cyclization reaction of <i>ortho</i>-electron-deficient alkynyl-substituted aryl aldehydes with indoles was accomplished, providing an efficient and economical way to synthesize indole-substituted indanones. The electron-withdrawing group attached to the alkyne and the nucleophilic indole play important roles in the formation of the indanone ring

Efficient Synthesis of Heterocyle-Fused β‑Naphthylamines via Intramolecular Addition to a Cyano Group Initiated by Nucleopalladation of Alkynes

A palladium­(II)-catalyzed efficient synthesis of heterocycle-fused β-naphthylamines was accomplished via nucleophilic addition of a carbon–palladium bond to the intramolecular cyano group initiated by nucleopalladation (oxypalladation or aminopalladation) of alkynes

Regiocontrolled Coupling of Aromatic and Vinylic Amides with α‑Allenols To Form γ‑Lactams via Rhodium(III)-Catalyzed C–H Activation

A mild, regiocontrolled coupling of aromatic and vinylic amides with α-allenols to form γ-lactams via rhodium­(III)-catalyzed C–H activation has been demonstrated. This [4 + 1] annulation reaction provides an efficient method for the synthesis of isoindolinones and 1,5-dihydro-pyrrol-2-ones bearing a tetrasubstituted carbon atom α to the nitrogen atom with good functional group tolerance. The hydroxyl group in the allene substrate is essential in controlling the chemo- and regioselectivity of the reaction probably by coordination interaction with the rhodium catalyst

Synthesis of Indole-Substituted Indanones via Palladium(II)-Catalyzed Tandem Reaction of <i>ortho</i>-Electron-Deficient Alkynyl-Substituted Aryl Aldehydes with Indoles

A Pd­(OAc)₂-catalyzed cyclization reaction of <i>ortho</i>-electron-deficient alkynyl-substituted aryl aldehydes with indoles was accomplished, providing an efficient and economical way to synthesize indole-substituted indanones. The electron-withdrawing group attached to the alkyne and the nucleophilic indole play important roles in the formation of the indanone ring

Cationic Pd(II)-Catalyzed Cyclization of <i>N</i>‑Tosyl-aniline Tethered Allenyl Aldehydes with Arylboronic Acids: Diastereo- and Enantioselective Synthesis of Tetrahydroquinoline Derivatives

An efficient cyclization of <i>N</i>-tosyl-aniline tethered allenyl aldehydes and arylboronic acids catalyzed by cationic palladium complex is developed. This annulation reaction provides a convenient process for the synthesis of 3,4-<i>cis</i>-1,2,3,4-tetrahydro­quinoline derivatives in high yields with excellent diastereoselectivity and enantioselectivity

Cationic Pd(II)-Catalyzed Highly Enantioselective Arylative Cyclization of Alkyne-Tethered Enals or Enones Initiated by Carbopalladation of Alkynes with Arylboronic Acids

Cationic Pd(II)-catalyzed enantioselective arylative cyclization of alkyne-tethered enals or enones initiated by carbopalladation of alkynes was developed without the necessity of a redox system