Genotype/allele frequencies of five polymorphisms in apelin/APJ system between CAD patients and controls.

*<p>Because the gene encoding apelin is mapped on the X chromosome, genotype data are unavailable.</p

MDR analysis summary.

*<p>The overall best MDR model.</p

Genomic organization of human apelin (upper panel) and APJ (lower panel) genes, and localization of examined polymorphisms.

<p>Each exon is represented by a black box. Lengths of exons and introns are on the proportional scale. The vertical line marks the position of each polymorphism.</p

The anthropometric index and clinical biomarkers of the study population between CAD patients and controls according to gender.

<p><i>Abbreviations</i>: BMI, body mass index; SBP, systolic blood pressure, DBP, diastolic blood pressure; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Apo A, Apolipoprotein A; Apo B, Apolipoprotein B; Lp(a), Lipoprotein(a); BUN, blood urea nitrogen; Cr, Creatinine; UA, uric acid; hsCRP, high sensitivity C-reactive protein. Continuous variables with skewed distributions were transformed in square for age; in log(10) for SBP, DBP, triglycerides, hsCRP; in square root for BMI, LDL-C, and comparison between CAD patients and controls was conducted using the unpaired t-test. The nonparametric Mann-Whitney U test was used for TC, HDL-C, Apo A, Apo B, Lp(a), glucose, BUN, Cr, and UA. Data are expressed as mean (standard deviation or SD). * For patients, age referred to the onset age of CAD, and for controls, age was recorded at enrollment.</p

The comparison of the MEF2A (CAG)₉ allele versus other alleles (with 4–8, 10–15 repeats) under a random effects model.

<p>The comparison of the MEF2A (CAG)₉ allele versus other alleles (with 4–8, 10–15 repeats) under a random effects model.</p

Meta-analysis of the effect of (CAG)₉ allele on CAD risk according to potential sources of heterogeneity.

<p>CAD: coronary artery disease; PCR: polymerase chain reaction; SSCP: single strand conformational polymorphism analysis.</p

Systematic review of the association between 21-bp deletion and CAD/MI.

<p>CAD: coronary artery disease; MI: myocardial infarction; PCR: polymerase chain reaction; SSCP: single strand conformational polymorphism analysis; MALDI-TOF MS: matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; FRET: fluorescence resonance energy transfer technology; HRMA: high resolution melting analysis.</p

The estimated frequencies of polymorphisms examined in apelin and APJ genes between CAD patients and controls according to the gender.

†<p>P values were calculated after adjusting for age, type 2 diabetes mellitus, body mass index and systolic blood pressure.</p

Genetic variations in <i>MEF2A</i> gene exon 11 discovered by sequencing in our study population.

1<p>Q = Gln; P = Pro; S = Ser; G = Gly.</p><p>STR: short tandem repeat polymorphism; SNP: single nucleotide polymorphism; AA: amino acid; MAF: minor allele frequency; OR: odds ratio; 95%CI: 95% confidence interval.</p