5 research outputs found
Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats
<p>We investigated whether fatty liver preceded insulin resistance or vice versa using a long-term orotic acid (OA)-induced nonalcoholic fatty liver disease (NAFLD) model without the confounding effects of obesity and hyperlipidemia and explored the role of the liver in insulin resistance. Male Wistar rats were fed with or without OA supplementation for 30, 60, and 90 days. The NAFLD group showed increased liver lipid at 30, 60, and 90 days; glucose intolerance was noted at 60 and 90 days. Furthermore, partial liver proteins and gene expressions related to upstream signaling of insulin were decreased. However, the liver glycogen content was elevated, and gluconeogenesis genes expressions were obviously decreased at 90 days. The occurrence of fatty liver preceded insulin resistance in OA-induced NAFLD without the interference of obesity and hyperlipidemia, and hepatic insulin resistance may not play a conclusive role in insulin resistance in this model.</p> <p>Whether fatty liver preceded insulin resistance (IR) or vice versa in a long-term orotic acid-induced NAFLD model without the confounding effects of obesity and hyperlipidemia.</p
Data S1 from Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats
Synergistic effect of EPA-PL and SCS on growth parameters in rats
Data S4 from Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats
Synergistic effects of EPA-PL and SCS on hepatic parameters in OA-fed rats
Data S2 from Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats
Synergistic effect of EPA-PL and SCS on serum parameters in rats
Data S3 from Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats
Synergistic effect of EPA-PL and SCS on hepatic lipid profiling in rats