159 research outputs found

    Radio-sensitizing effect of ethyl caffeate on nasopharyngeal carcinoma CNE-2 cell line

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    Purpose: To investigate the radio-sensitizing effect of ethyl caffeate (ETF) on naso-pharyngeal carcinoma.Methods: MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay was used to evaluate the cell viability of CNE-2 cells, while their levels of caspase-3 and caspase-9 were determined by enzyme-linked immunosorbent assay (ELISA). In addition, a xenograft model was established in nude mice. The model was treated with ETF (40 mg/kg) and subjected to β-irradiation (10 Gy) for 28 days, during which tumor volume was determined at 4-day intervals. Expressions of caspase-3, caspase-9 and Bcl-2 were determined by western blotting assay.Results: β-irradiation (10 Gy) did not produce any obvious inhibitory effect on the proliferation of CNE-2 cells. However, ETF (10, 20 and 40 μg/mL) significantly enhanced the radiosensitivity of the cells to β- irradiation (p < 0.01) and significantly increased their levels of caspase-3 and caspase-9 (p < 0.01). The combination of ETF (40 mg/kg) with β-irradiation resulted in significant inhibition of tumor growth in mice xenograft model (p < 0.01). The combined treatment also resulted in significant up-regulation of expressions of caspase-3 and casepase-9 and significant down-regulation of Bcl-2 in the tumor tissues when compared with corresponding tissues from the control mice (p < 0.01).Conclusion: ETF significantly enhances the sensitivity of naso-pharyngeal carcinoma CNE-2 cells to β- irradiation, probably through induction of mitochondria-mediated apoptosis. ETF may be useful for treating naso-pharyngeal carcinoma in combination with radiation therapy.Keywords: Ethyl caffeate, Radio-sensitizing effects, Caspase, Nasopharyngeal carcinoma, CNE-2 cell line, β-irradiatio

    Threshold current of field-free perpendicular magnetization switching using anomalous spin-orbit torque

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    Spin-orbit torque (SOT) is a candidate technique in next generation magnetic random-access memory (MRAM). Recently, experiments show that some material with low-symmetric crystalline or magnetic structures can generate anomalous SOT that has an out-of-plane component, which is crucial in switching perpendicular magnetization of adjacent ferromagnetic (FM) layer in the field-free condition. In this work, we analytically derive the threshold current of field-free perpendicular magnetization switching using the anomalous SOT. And we numerically calculate the track of the magnetic moment in a FM free layer when an applied current is smaller and greater than the threshold current. After that, we study the applied current dependence of the switching time and the switching energy consumption, which shows the minimum energy consumption decreases as out-of-plane torque proportion increases. Then we study the dependences of the threshold current on anisotropy strength, out-of-plane torque proportion, FM free layer thickness and Gilbert damping constant, and the threshold current shows negative correlation with the out-of-plane torque proportion and positive correlation with the other three parameters. Finally, we demonstrate that when the applied current is smaller than the threshold current, although it cannot switch the magnetization of FM free layer, it can still equivalently add an effective exchange bias field H_{bias} on the FM free layer. The H_{bias} is proportional to the applied current J_{SOT}, which facilitates the determination of the anomalous SOT efficiency. This work helps us to design new spintronic devices that favor field-free switching perpendicular magnetization using the anomalous SOT, and provides a way to adjust the exchange bias field, which is helpful in controlling FM layer magnetization depinning

    Spin transport and dynamic properties of two-dimensional spin-momentum locked states

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    Materials with spin-momentum locked surface or interface states provide an interesting playground for studying physics and application of charge-spin current conversion. To characterize their non-equilibrium magnetic and transport properties in the presence of a time-dependent external magnetic field and a spin injection from a contact, we introduce three macroscopic variables: a vectorial helical magnetization, a scaler helical magnetization, and the conventional magnetization. We derive a set of closed dynamic equations for these variables by using the spinor Boltzmann approach with the collision terms consistent with the symmetry of spin-momentum locked states. By solving the dynamic equations, we predict several intriguing magnetic and transport phenomena which are experimentally accessible, including magnetic resonant response to an AC applied magnetic field, charge-spin conversion, and spin current induced by the dynamics of helical magnetization

    Composite metamaterials with dual-band magnetic resonances in the terahertz frequency regime

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    Composite metamaterials(CMMs) combining a subwavelength metallic hole array (i.e. one-layer fishnet structure) and an array of split-ring resonators(SRRs) on the same board are fabricated with gold films on silicon wafer. Transmission measurements of the CMMs in the terahertz range have been performed. Dual-band magnetic resonances, namely, a LC resonance at 4.40 THz and an additional magnetic resonance at 8.64 THz originating from the antiparallel current in wire pairs in the CMMs are observed when the electrical field polarization of the incident light is parallel to the gap of the component SRR. The numerical simulations agree well with the experimental results and further clarify the nature of the dual-band magnetic resonances.Comment: 4 figures, 14 page

    Surface plasmon polaritons assisted diffraction in periodic subwavelength holes of metal films with reduced interplane coupling

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    Metal films grown on Si wafer perforated with a periodic array of subwavelength holes have been fabricated and anomalous enhanced transmission in the mid-infrared regime has been observed. High order transmission peaks up to Si(2,2) are clearly revealed due to the large dielectric constant contrast of the dielectrics at the opposite interfaces. Si(1,1) peak splits at oblique incidence both in TE and TM polarization, which confirms that anomalous enhanced transmission is a surface plasmon polaritons (SPPs) assisted diffraction phenomenon. Theoretical transmission spectra agree excellently with the experimental results and confirm the role of SPPs diffraction by the lattice.Comment: 4 pages, 5 figures, 26 reference

    A Flexible Sensor and MIMU-Based Multisensor Wearable System for Human Motion Analysis

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    Motivation: Magnetic–inertial measurement units (MIMUs) and flexible sensors are widely used in the wearable measurement system for human motion monitoring, clinical gait detection, and robotics motion control. However, MIMUs demonstrate measurement error due to magnetic disturbance in the indoor environment, and flexible sensors usually have low performance on linearity and accuracy. Objective: This article is intended to eliminate the low-accuracy problem caused by magnetic disturbances and improve the measurement accuracy of MIMU–flexible-sensor-based wearable systems. Approach: 1) a three-stage real-time adaptive anti-disturbance data fusion (RT-ADF) algorithm is proposed, which contains an anti-disturbance filter based on a double Mahony filter along with a state observer, a signal holder for sensors’ data transmit synchronously, and a data fusion based on an adaptive Kalman filter; 2) the proposed algorithm is used and validated its performance on a designed MIMU–flexible sensor wearable system; and 3) ten groups of knee motions (flexion/extension), ten groups of hip motions (adduction/abduction), and ten groups of elbow motions (flexion/extension) have been done by seven subjects in the experiments. Main Results: The designed multisensor wearable system based on the presented data fusion algorithm demonstrates a high-accuracy performance under the magnetic disturbance environment, and the maximum root mean square error (RMSE) of the measured continuous 3-D motion angle of the knee, hip, and elbow cross all the experiments was 1.23°, 1.15°, and 3.67° for each axis.<br/
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