Clinical characteristics of ILI-patients in PKU People' Hospital between June 2010 and May 2011.

<p>Values are median (IQR) or n (%) of patients unless otherwise stated. Normally distributed data are reported as means with 95% CI and non-normally distributed data as medians with interquartile range.</p><p>The characteristics contain demography characteristics, medical history, presenting symptoms, and clinical findings.</p><p>*Positive cases for at least one respiratory virus except Influenza A viruses by RT-PCT.</p><p>**Telephone follow-up data mainly for RT-PCR-positive patients.</p>##<p>Includes all ILI cases regardless of virology RT-PCR test results.</p

Monthly distribution of test-positive virus in the PKU People' hospital from June 2010 to May 2011.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028786#pone-0028786-g001" target="_blank">Figure 1A</a> shows the number of respiratory specimens testing positive for influenza, by influenza type and positive rates of respiratory virus. Panel B shows the smaller number of other viruses. The rate of positive cases of the virus gradually increased from August to October, slowly decreased in November, and then increased again in January 2011. The peak of the positive rate occurred in January 2011 and influenza was the predominant virus between August 2010 and March 2011. Particularly in August, September and October 2010, and March 2011, all infections were caused by FLU only( <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028786#pone-0028786-g001" target="_blank">Figure 1B</a>). The number of positive cases of influenza virus increased rapidly in September and peaked in January 2011, following which it then decreased to normal levels in March 2011. Influenza A(H3) was the predominant viral etiological factor and was only observed from July to December 2010, and again, in January 2011, Influenza A(H3) were replaced by 2009 H1N1. 2009 H1N1 peaked in January 2011. Most influenza viruses were in fact influenza A, with influenza B virus only observed in April 2011. In June, multiple infections predominated. Each identified ILI was caused by a single virus except in June, July and November 2010 and January and February 2011: two FLU-A in August, eight FLU-A in September and in October each, eight FLU-A and one HRCV229E/NL63 in December, four FLU-A in March 2011, one FLU-A, two FLU-B and one ADV in April 2011, No virus was detected in May 2011. On the other hand, two of the three identified ILI samples in June were mixed infections, HRSV and HRV. Other double infections included: One HRCV/FLU-A in July, one FLU-A/HRV in November, two HRSV-A and FLU-A and one HRSV-A and HRV and FLU-A in January 2011, one HRSV-A and HRV and FLU-A in February 2011.</p

ILI rates in North China from June 2009 to May 2010 and June 2010 to May 2011.

<p>The weekly ILI rate increased rapidly in the 35^th week of 2009 in North China, with the highest weekly ILI rate of 12.1 cases per 100 consultations occurring in the 44^th week. However, the rate was relatively stable on the basis of the weekly ILI surveillance system of North China in 2010. The incidence rose slightly in January 2011 and the usual influenza seasonal peak appeared in the 5^th week of 2011. The percentage of patient visits for ILI peaked at 5.0% in the influenza 2010–2011 season. ^▴The ILI rate of North China derived from data obtained from the Chinese National Influenza Center (CNIC).</p

The adult outpatient service capacity of the Infectious Diseases Department of PKUPH, 2009–2011.

<p>In 2010, the overall number of outpatients was less than that of 2009, particularly between May and December. From May 2009, when pH1N1 emerged in Beijing, the capacity of the outpatient service of the Infectious Diseases Department of PKU People's Hospital increased rapidly. The number of outpatients peaked in November 2009, following which. The volume declined to reach normal levels in the third month of 2010. The numbers of outpatients was relatively stable in 2010, with an increase during November and December and a further peak in January 2011.</p

Characteristics of FLU-A and non-FLU-A ILI-patients in PKU People' Hospital betweenJune 2010 and May 2011.

<p>*Total of 8(4.2%) participants missing information on routine examination results: 5 in the FLU-A-positive ILI-case group and 3 in the FLU-A-negative ILI-case group.</p><p>**Nine patients were missing perceived in the FLU-A-negative ILI-case group.</p

Clinical characteristics of 120 patients with suspected ATB.

<p>ATB, active tuberculosis; Not ATB, diagnosis other than active tuberculosis; CXR, Chest X-ray; HAART, Highly active antiretroviral therapy; PCP, Pneumocystic pneumonia; *p<0.05 if compared with Not ATB group.</p

Diagnostic performance of TSPOT.TB.

<p>PPV, positive predictive value; NPV, negative predictive value; LR+, likelihood ratio for positive test; LR−, likelihood ratio for negative test.</p

Laboratory findings of 120 patients with suspected ATB.

<p>ATB, active tuberculosis; Not ATB, diagnosis other than active tuberculosis; ESR, erythrocyte sedimentation rate; WBC, white blood cells; RBC, red blood cells; *, p<0.05 if compared with Not ATB group.</p

Diagnostic performance of the combination of T-SPOT.TB and TST.

<p>PPV, positive predictive value; NPV, negative predictive value; TST, tuberculin skin test; ^a, parallel: either TST or T-SPOT.TB is positive; ^b, serial: both TST and T-SPOT.TB are positive;</p

Diagnostic performance of the combination of T-SPOT.TB and TST by infection sites.

<p>Extrapul, extra-pulmonary conditions; PPV, positive predictive value; NPV, negative predictive value; TST, tuberculin skin test; ^a, parallel: either TST or T-SPOT.TB is positive; ^b, serial: both TST and T-SPOT.TB are positive.</p