1,586 research outputs found
Methyl 2-hydroxy-3-nitrobenzoate
The title compound, C8H7NO5, assumes an approximately planar molecular structure with an intramolecular O—H⋯O hydrogen bond between the hydroxy and carboxylate groups. Weak intermolecular C—H⋯O hydrogen bonding is present in the crystal structure
Dibromido{2-hydroxy-N′-[phenyl(2-pyridyl)methylene]benzohydrazide}copper(II)
In the title complex, [CuBr2(C19H15N3O2)], the metal ion is coordinated by the N,N′,O-tridentate 2-hydroxy-N′-[phenyl(2-pyridyl)methylene]benzohydrazide ligand and two bromide ions, resulting in a distorted CuN2OBr2 square-based pyramidal coordination geometry with one bromide ion in the apical site. An intramolecular N—H⋯O hydrogen bond occurs in the ligand. In the crystal, molecules are connected by intermolecular C—H⋯O, C—H⋯Br and O—H⋯Br interactions
Bis(4-aminobenzenesulfonato-κO)bis(propane-1,3-diamine-κ2 N,N′)copper(II) dihydrate
In the title compound, [Cu(C3H10N2)2(C6H6NO3S)2]·2H2O, the CuII atom lies on an inversion center and is hexacoordinated by four N atoms from two 1,3-diaminopropane ligands and two O atoms from two 4-aminobenzenesulfonate ligands in a trans arrangement, displaying a distorted and axially elongated octahedral coordination geometry, with the O atoms at the axial positions. A three-dimensional network is formed in the crystal structure through O—H⋯O, N—H⋯O and N—H⋯N hydrogen bonds
Diaquabis(picolinato N-oxide-κ2 O,O′)zinc(II)
In the title compound, [Zn(C6H4NO3)2(H2O)2], the Zn atom is located on a centre of inversion and shows a distorted octahedral coordination geometry. Two aqua ligands occupy the axial positions and four O atoms of the two chelating picolinic acid N-oxide ligands are located in the equatorial plane. Intermolecular hydrogen bonds between aqua ligands and organic ligands link molecules into a two-dimensional arrangement
Bis(dicyanamido-κN 1)bis[2-(2-hydroxyethyl)pyridine-κ2 N,O]nickel(II)
In the title complex, [Ni{N(CN)2}2(C7H9NO)2], the NiII ion (site symmetry ) adopts a distorted trans-NiO2N4 octahedral geometry. In the crystal, intermolecular O—H⋯N hydrogen bonds link the molecules, forming a chain along the c axis
Prognostic value of vitamin D in patients with pneumonia: A systematic review and meta-analysis
Purpose: To investigate the prognostic role of vitamin D in pneumonia patients through meta-analysis.Methods: PubMed and Embase were systematically searched for relevant studies that assessed the impact of vitamin D on the risk of adverse outcomes among patients with pneumonia. Risk ratios (RR) with 95 % confidence intervals (95 % CI) were pooled using meta-analysis. Q-test and I2 statistics were used to evaluate between-study heterogeneity.Results: Six studies were finally included in the meta-analysis. The results of meta-analysis of these studies indicated that low vitamin D status was associated with higher risk of mortality among pneumonia patients (RR = 2.59, 95 % CI = 1.32-5.08; p = 0.005). Results from meta-analysis of studies with adjusted estimates suggest that low vitamin D status was independently associated with higher risk of mortality among pneumonia patients (RR = 3.15, 95 % CI 1.54-6.44, p = 0.002). There was no significant risk of bias in the meta-analysis.Conclusion: This study demonstrates that low vitamin D level is associated with a higher risk of adverse outcomes in patients with pneumonia.Keywords: Pneumonia, Vitamin D, Prognosis, Meta-analysis, Systematic revie
Penicillamine Increases Free Copper and Enhances Oxidative Stress in the Brain of Toxic Milk Mice
Wilson disease (WD) is characterized by the accumulation of copper arising from a mutation in the ATP7B gene. Penicillamine (PA) makes 10–50% of the patients with neurologic symptoms neurologically worse at the early stage of administration. The aim of this study was to determine how the copper metabolism changes and whether the change impairs the brain of toxic milk (tx) mice, an animal model of WD, during the PA administration. The free copper and protein-bound copper concentrations in the serum, cortex and basal ganglia of tx mice with PA administration for 3 days, 10 days and 14 days, respectively, were investigated. The expression of copper transporters, ATP7A and CTR1,was analyzed by real-time quantitative PCR, immunofluorescence and Western blot. Then SOD, MDA and GSH/GSSG were detected to determine whether the oxidative stress changed correspondingly. The results revealed the elevated free copper concentrations in the serum and brain, and declined protein-bound copper concentrations in the brain of tx mice during PA administration. Meanwhile, transiently increased expression of ATP7A and CTR1 was observed generally in the brain parenchyma by immunofluorescence, real-time quantitative PCR and Western blot. Additionally, ATP7A and CTR1 were observed to locate mainly at Golgi apparatus and cellular membrane respectively. Intense staining of ATP7A in the choroid plexus was found in tx mice on the 3rd and 10th day of PA treatment, but rare staining of ATP7A and CTR1 in the blood-brain barrier (BBB). Decreased GSH/GSSG and increased MDA concentrations were also viewed in the cortex and basal ganglia. Our results suggested the elevated free copper concentrations in the brain might lead to the enhanced oxidative stress during PA administration. The increased free copper in the brain might come from the copper mobilized from brain parenchyma cells but not from the serum according to the ATP7A and CTR1 expression analysis
- …