Study on Smoke Control of Wuhan CBD Urban Traffic Link Tunnel

AbstractAn Urban Traffic Link Tunnel (UTLT) is a novel type of underground transportation system consisting of a main tunnel in a loop shape and several linked tunnels. It has a higher level of fire risk compared to other common road tunnels. In this study, numerical and experimental study has been conducted to investigate the smoke control of Wuhan Central Business District (CBD) UTLT. The transient distributions of the smoke spread have been analyzed, and the optimal smoke control strategy for the Wuhan CBD UTLT has been put forward

Optimization of network structure to random failures

Network's resilience to the malfunction of its components has been of great concern. The goal of this work is to determine the network design guidelines, which maximizes the network efficiency while keeping the cost of the network (that is the average connectivity) constant. With a global optimization method, memory tabu search (MTS), we get the optimal network structure with the approximately best efficiency. We analyze the statistical characters of the network and find that a network with a small quantity of hub nodes, high degree of clustering may be much more resilient to perturbations than a random network and the optimal network is one kind of highly heterogeneous networks. The results strongly suggest that networks with higher efficiency are more robust to random failures. In addition, we propose a simple model to describe the statistical properties of the optimal network and investigate the synchronizability of this model.Comment: 11 pages, 6 figures, accepted by Physica

Expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma: correlations with clinicopathologic features

The aim of this study was to evaluate the expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma (PFTC), as well as their correlations with clinicopathologic features. We studied a cohort of 33 patients with a pathological diagnosis of PFTC. Thirty normal tubal tissues used for controls were obtained from patients diagnosed with uterine myomas. Expression analysis for COX-2 and Bcl-2 was performed using the immunohistochemical technique. The rate of preoperative diagnosis was 18.2%. With a median survival of 61.0 months (95% CI: 43.2 to 78.8 months), the estimated five-year overall survival rate in the 33 patients was 39.0%. Increased expression of COX-2 and Bcl-2 was observed in tumor specimens compared to normal controls (p = 0.026; p = 0.003). The expression rate of COX-2 in node-positive tumors was significantly higher than that of node-negative tumors (p = 0.024). Moreover, the expression rate of COX-2 was statistically significantly higher in patients with infiltration through the serosa (p = 0.019). Positive significant associations were observed between Bcl-2 staining index and FIGO stage (p = 0.015), and between Bcl-2 staining and lymph node metastasis (p = 0.010). There was a significant correlation between COX-2 expression and Bcl-2 staining index (r = 0.517, p = 0.002). We conclude that COX-2 and Bcl-2 may potentially be useful prognostic markers for PFTC. The exact molecular mechanism for correlations between COX-2 and Bcl-2 remains to be elucidated. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 3, 389–397

Generation of γ\gamma photons with extremely large orbital angular momenta

Vortex $\gamma$ photons, which carry large intrinsic orbital angular momenta (OAM), have significant applications in nuclear, atomic, hadron, particle and astro-physics, but their production remains unclear. In this work, we investigate the generation of such photons from nonlinear Compton scattering of circularly polarized monochromatic lasers on vortex electrons. We develop a quantum radiation theory for ultrarelativistic vortex electrons in lasers by using the harmonics expansion and spin eigenfunctions, which allows us to explore the kinematical characteristics, angular momentum transfer mechanisms, and formation conditions of vortex $\gamma$ photons. The multiphoton absorption of electrons enables the vortex $\gamma$ photons, with fixed polarizations and energies, to exist in mixed states comprised of multiple harmonics. Each harmonic represents a vortex eigenmode and has transverse momentum broadening due to transverse momenta of the vortex electrons. The large topological charges associated with vortex electrons offer the possibility for $\gamma$ photons to carry adjustable OAM quantum numbers from tens to thousands of units, even at moderate laser intensities. $\gamma$ photons with large OAM and transverse coherence length can assist in influencing quantum selection rules and extracting phase of the scattering amplitude in scattering processes.Comment: 7 pages, 4 figure

Vaccinium usneoides (Ericaceae), a new species from Yunnan, China

Vaccinium usneoides (Ericaceae), a new species from Fugong County of Yunnan Province, China is described and illustrated. This new species belongs to Vaccinium sect. Calcicolus and is most similar to V. brachyandrum, but differs in its branches hanging down, much smaller leaf blades, shorter inflorescences and pedicels, non-glandular tomentellate or densely pubescent inflorescence rachis and pedicels, densely white-pubescent hypanthium and pilose filaments

A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III

We established a method on measuring the \dzdzb mixing parameter $y$ for BESIII experiment at the BEPCII $e^+e^-$ collider. In this method, the doubly tagged $\psi(3770) \to D^0 \overline{D^0}$ events, with one $D$ decays to CP-eigenstates and the other $D$ decays semileptonically, are used to reconstruct the signals. Since this analysis requires good $e/\pi$ separation, a likelihood approach, which combines the $dE/dx$, time of flight and the electromagnetic shower detectors information, is used for particle identification. We estimate the sensitivity of the measurement of $y$ to be 0.007 based on a $20fb^{-1}$ fully simulated MC sample.Comment: 6 pages, 7 figure

Antrodia camphorata Mycelia Exert Anti-liver Cancer Effects and Inhibit STAT3 Signaling in vitro and in vivo

Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is a common cause of cancer-related death worldwide. Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in HCC and has been proposed as a chemotherapeutic target for HCC. Antrodia camphorata (AC), a medicinal mushroom unique to Taiwan, is traditionally used for treating HCC. Whereas natural AC is scarce, cultured AC mycelia are becoming alternatives. In this study, we investigated the anti-HCC effects of the ethyl acetate fraction of an ethanolic extract of AC mycelia (EEAC), particularly exploring the involvement of STAT3 signaling in these effects. We found that EEAC reduced cell viability, induced apoptosis, and retarded migration and invasion in cultured HepG2 and SMMC-7721 cells. Immunoblotting results showed that EEAC downregulated protein levels of phosphorylated and total STAT3 and JAK2 (an upstream kinase of STAT3) in HCC cells. Real-time PCR analyses showed that STAT3, but not JAK2, mRNA levels were decreased by EEAC. EEAC also lowered the protein level of nuclear STAT3, decreased the transcriptional activity of STAT3, and downregulated protein levels of STAT3-targeted molecules, including anti-apoptotic proteins Bcl-xL and Bcl-2, and invasion-related proteins MMP-2 and MMP-9. Over-activation of STAT3 in HCC cells diminished the cytotoxic effects of EEAC. In SMMC-7721 cell-bearing mice, EEAC (100 mg/kg, i.g. for 18 days) significantly inhibited tumor growth. Consistent with our in vitro data, EEAC induced apoptosis and suppressed JAK2/STAT3 activation/phosphorylation in the tumors. Taken together, EEAC exerts anti-HCC effects both in vitro and in vivo; and inhibition of STAT3 signaling is, at least in part, responsible for these effects. We did not observe significant toxicity of EEAC in normal human liver-derived cells, nude mice and rats. Our results provide a pharmacological basis for developing EEAC as a safe and effective agent for HCC management

An Updated Search of Steady TeV γ−\gamma-Ray Point Sources in Northern Hemisphere Using the Tibet Air Shower Array

Using the data taken from Tibet II High Density (HD) Array (1997 February-1999 September) and Tibet-III array (1999 November-2005 November), our previous northern sky survey for TeV $\gamma-$ray point sources has now been updated by a factor of 2.8 improved statistics. From $0.0^{\circ}$ to $60.0^{\circ}$ in declination (Dec) range, no new TeV $\gamma-$ray point sources with sufficiently high significance were identified while the well-known Crab Nebula and Mrk421 remain to be the brightest TeV $\gamma-$ray sources within the field of view of the Tibet air shower array. Based on the currently available data and at the 90% confidence level (C.L.), the flux upper limits for different power law index assumption are re-derived, which are approximately improved by 1.7 times as compared with our previous reported limits.Comment: This paper has been accepted by hepn