The Features of Genetic Prion Diseases Based on Chinese Surveillance Program

<div><p>Objective</p><p>To identify the features of Chinese genetic prion diseases.</p><p>Methods</p><p>Suspected Creutzfeldt-Jakob disease (CJD) cases that were reported under CJD surveillance were diagnosed and subtyped using the diagnostic criteria issued by the WHO. The general information concerning the patient, their clinical, MRI and EEG data, and the results of CSF 14-3-3 and <i>PRNP</i> sequencing were carefully collected from the database of the national CJD surveillance program and analyzed using the <i>SPSS 11</i>.<i>5</i> statistical software program.</p><p>Results</p><p>Since 2006, 69 patients were diagnosed with genetic prion diseases and as having 15 different mutations. The median age of the 69 patients at disease onset was 53.5 years, varying from 19 to 80 years. The majority of patients displaying clinical symptoms were in the 50–59 years of age. FFI, T188K gCJD and E200K were the three most common subtypes. The disease appeared in the family histories of 43.48% of the patients. The clinical manifestations varied considerably among the various diseases. Patients who carried mutations in the N-terminus displayed a younger age of onset, were CSF 14-3-3 negative, had a family history of the condition, and experienced a longer duration of the condition. The clinical courses of T188K were significantly shorter than those of FFI and E200K gCJD, while the symptoms in the FFI group appeared at a younger age and for a longer duration. Moreover, the time intervals between the initial neurologist visit to the final diagnosis were similar among patients with FFI, T188K gCJD, E200K gCJD and other diseases.</p><p>Conclusion</p><p>The features of Chinese genetic prion diseases are different from those seen in Europe and other Asian countries.</p></div

The clinical manifestations of various human genetic prion diseases.

<p>The clinical manifestations of various human genetic prion diseases.</p

Family histories and <i>PRNP</i> sequencing results of various human genetic prion diseases.

<p>Family histories and <i>PRNP</i> sequencing results of various human genetic prion diseases.</p

The age of onset of patients of various genetic prion diseases.

<p>A. Distribution of the age of onset based upon the types of disease. The median onset age of all 69 patients is indicated by a dotted line. The median onset age of each disease is illustrated with a short, red bar. B. Distribution of the age of onset based upon decade of life. C. Distribution of the age of onset based upon the disease type and decade of life.</p

CSF 14-3-3, MRI and EEG status in various human genetic prion diseases.

<p>CSF 14-3-3, MRI and EEG status in various human genetic prion diseases.</p