A new <i>α</i>-pyrone from the mangrove endophytic fungus <i>Phomopsis</i> sp. HNY29-2B

<p>A new <i>α</i>-pyrone derivative, phomopyrone A (<b>1</b>), together with two known compounds (<b>2</b>–<b>3</b>), was isolated from the culture of the mangrove endophytic fungus <i>Phomopsis</i> sp. HNY29-2B. Their structures were determined by detailed analysis of spectroscopic data. The configuration of <b>1</b> was further confirmed by X-ray diffraction. All isolated compounds were evaluated for antibacterial and antioxidative activities. Compound <b>2</b> exhibited antibacterial activities with minimal inhibition concentration (MIC) values of 25 and 50 μM against <i>Bacillus subtilis</i> and <i>Pseudomonas aeruginosa</i>, and compound <b>3</b> showed activities against <i>Staphylococcus aureus</i> and <i>B. subtilis</i> with MIC values of 25 and 50 μM, respectively.</p

Diaporisoindoles A–C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic Fungus <i>Diaporthe</i> sp. SYSU-HQ3

Diaporisoindoles A (<b>1</b>) and B (<b>2</b>), two novel isoprenylisoindole alkaloids, and an unusual diisoprenylisoindole dimer diaporisoindole C (<b>3</b>), together with a precursor tenellone C (<b>4</b>) were all isolated from the endophytic fungus <i>Diaporthe</i> sp. SYSU-HQ3. The absolute configurations of <b>1</b>–<b>4</b> were elucidated by spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Diaporisoindole A (<b>1</b>) and tenellone C (<b>4</b>) exhibited inhibitory activity against <i>Mycobacterium tuberculosis</i> protein tyrosine phosphatase B with IC₅₀ values of 4.2 and 5.2 μM

Xylanthraquinone, a new anthraquinone from the fungus <i>Xylaria</i> sp. 2508 from the South China Sea

<div><p>Xylanthraquinone (<b>1</b>), a new anthraquinone, along with three known compounds, altersolanol A (<b>2</b>), deoxybostrycin (<b>3</b>) and bostrycin (<b>4</b>) was isolated from the fungus <i>Xylaria</i> sp. 2508 from the South China Sea. The structures of these compounds were identified by NMR experiments, and the absolute configuration of compound <b>1</b> was further confirmed by single-crystal X-ray diffraction with Cu Kα radiation. Compounds <b>1</b>–<b>4</b> did not show inhibitory activities against Mycobacterium tuberculosis protein tyrosine phosphatase B (IC₅₀ values more than 100 μM).</p></div

Asperterpenoid A, a New Sesterterpenoid as an Inhibitor of <i>Mycobacterium tuberculosi</i>s Protein Tyrosine Phosphatase B from the Culture of <i>Aspergillus</i> sp. 16-5c

Asperterpenoid A (<b>1</b>), a novel sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus <i>Aspergillus</i> sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (<b>1</b>) exhibited strong inhibitory activity against <i>Mycobacterium tuberculosis</i> protein tyrosine phosphatase B (<i>m</i>PTPB) with an IC₅₀ value of 2.2 μM

Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. 085242

Asperterpenol A (<b>1</b>) and asperterpenol B (<b>2</b>), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus <i>Aspergillus</i> sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds <b>1</b> and <b>2</b> inhibit acetylcholinesterase with IC₅₀ values of 2.3 and 3.0 μM, respectively

Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. 085242

Asperterpenol A (<b>1</b>) and asperterpenol B (<b>2</b>), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus <i>Aspergillus</i> sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds <b>1</b> and <b>2</b> inhibit acetylcholinesterase with IC₅₀ values of 2.3 and 3.0 μM, respectively

Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. 085242

Asperterpenol A (<b>1</b>) and asperterpenol B (<b>2</b>), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus <i>Aspergillus</i> sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds <b>1</b> and <b>2</b> inhibit acetylcholinesterase with IC₅₀ values of 2.3 and 3.0 μM, respectively

Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010

Two new sesterterpenoids, aspterpenacids A (<b>1</b>) and B (<b>2</b>), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for <b>1</b> and <b>2</b> is proposed. Both <b>1</b> and <b>2</b> showed no significant antibacterial activity or cytotoxicity at 50 μM

Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010

Two new sesterterpenoids, aspterpenacids A (<b>1</b>) and B (<b>2</b>), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for <b>1</b> and <b>2</b> is proposed. Both <b>1</b> and <b>2</b> showed no significant antibacterial activity or cytotoxicity at 50 μM