Association between polymorphisms of the <i>GSDMB</i> gene and allergic rhinitis risk in the Chinese population: a case-control study

Allergic rhinitis (AR) is a great risk factor for developing asthma, and its pathogenesis is affected by various factors, such as gene and environment. GSDMB is related to allergic diseases. Our purpose is to explore the correlation of single nucleotide polymorphisms (SNPs) in GSDMB and AR risk in the Chinese population. We performed a case-control study including 1005 cases and 1004 controls. Rs2305479, rs4795400, and rs12450091 in GSDMB were geneotyped using Agena MassARRAY. The relationships between GSDMB SNPs and AR risk were assessed by logistic regression analysis in PLINK1.9. Our study showed that rs4795400 was a protective factor for AR in overall (TT vs. CC: OR = 0.66, p = 0.009; TT vs. CC/TC: OR = 0.67, p = 0.008; additive: OR = 0.87, p = 0.042 males, people with BMI ≤ 24, and living in wind-blown sand area. Rs2305479 was associated with a reduced AR risk in males (TT vs. CC: OR = 0.47, p = 0.014; TT vs. CC/TC: OR = 0.43, p = 0.004). However, rs12450091 was a risk factor for AR in people living in the loess hilly region (CC: OR = 4.75, p = 0.047). The levels of EO and EO_per in the case group were significantly higher than those in the control group (p  This study indicated that GSDMB polymorphisms (rs4795400, rs2305479, and rs12450091) were associated with AR susceptibility. Further studies are required to confirm our findings and to clarify the functional relationship.</p

Additional file 2: Table S2. of miR-539 inhibits prostate cancer progression by directly targeting SPAG5

Prognostic value of SPAG5 protein expression for the biochemical recurrence free survival in univariate and multivariate analyses by Cox regression. (DOC 34 kb

Additional file 3: Table S3. of miR-539 inhibits prostate cancer progression by directly targeting SPAG5

Prognostic value of SPAG5 protein expression for the overall survival in univariate and multivariate analyses by Cox regression. (DOC 34 kb

Desorption Kinetics of Naphthalene and Acenaphthene over Two Activated Carbons via Thermogravimetric Analysis

Activated carbon (AC) is a promising sorbent for adsorption removal of polycyclic aromatic hydrocarbons (PAHs) because of its cost effectiveness. The desorption kinetics of two-ring PAHs, naphthalene and acenaphthene, over bituminous-coal-based (AC_WY) and coconut-shell-based (AC_NT) activated carbons were investigated. The desorption kinetics were studied over the temperature range of 400–800 K at different heating rates (8–20 K/min) using thermogravimetric analysis techniques. The activation energy, pre-exponential factor, and kinetic model for each sorbate–sorbent pair were determined by applying analytical methods to the non-isothermal data. The Johnson–Mehl–Avrami (JMA) rate equation, <i>g</i>(α) = [−ln­(1 – α)]^<i>n</i> (in integral form, where α is fractional completion), following the nucleation and growth model, was found to best describe the PAH desorption from both sorbents. Strong molecular sieving effects were found to influence both adsorption capacity and desorption rates. AC_WY, with less micropore (<0.7 nm) volume and more larger pores (0.7–2 nm) compared to AC_NT, favors PAH adsorption and desorption rates, leading to different values of the kinetic exponent (<i>n</i>) and other kinetic parameters. Likewise, the sieving effects favor adsorption and desorption of naphthalene (kinetic diameter of 0.62 nm) over acenaphthene (kinetic diameter of 0.66 nm) for both carbons

Additional file 5: Figure S2. of miR-539 inhibits prostate cancer progression by directly targeting SPAG5

miR-539 is downexpressed in primary PCa and metastatic PCa. miR-539 level was gradually decreased in normal prostate, primary PCa, and metastatic PCa samples. (JPG 173 kb

Additional file 4: Figure S1. of miR-539 inhibits prostate cancer progression by directly targeting SPAG5

miR-539 inhibits PCa cell proliferation, migration and invasion by targeting SPAG5 in vitro. A, Ectopic expression of miR-539 can mimic the suppression of colony formation induced by SPAG5 knockdown in PC-3 and LNCaP cells; B, Ectopic expression of miR-539 can mimic the suppression of migration activity induced by SPAG5 knockdown in PC-3 and LNCaP cells; C, Ectopic expression of miR-539 can mimic the suppression of invasion activity induced by SPAG5 knockdown in PC-3 and LNCaP cells; D, The efficiency of SPAG5 knockdown and ectopic expression of miR-539 was confirmed at protein level by western blot. (JPG 145 kb

Synthesis, Antibacterial Activity, and Mechanisms of Novel Indole Derivatives Containing Pyridinium Moieties

The development of effective antibacterial agents equipped with novel action modes and unique skeletons starting from natural compounds serves as an important strategy in the modern pesticide industry. Disclosed here are a series of novel indole derivatives containing pyridinium moieties and their antibacterial activity evaluation against two prevalent phytopathogenic bacteria, Xanthomonas oryzae pv. oryzicola (Xoc) and X. oryzae pv. oryzae (Xoo). A three-dimensional (3D)-QSAR model was adopted to discover higher activity like title compounds based on the Xoc antibacterial activity of the tested compounds. Compound 43 was consequently designed, and it displayed higher antibacterial activity as expected with the half-maximal effective concentration EC50 values of 1.0 and 1.9 μg/mL for Xoo and Xoc, respectively, which were better than those of the commercial drug thiodiazole copper (TC) (72.9 and 87.5 μg/mL). Under greenhouse conditions, the results of a rice in vivo pot experiment indicated that the protective and curative activities of compound 43 against rice bacterial leaf streak (BLS) and rice bacterial blight (BLB) were 45.0 and 44.0% and 42.0 and 39.3%, respectively, which were better than those of the commercial agent thiodiazole copper (38.0 and 37.9%, 38.6 and 37.0%) as well. Scanning electron microscopy images, defense enzyme activity tests, and proteomic techniques were utilized in a preliminary mechanism study, suggesting that compound 43 shall modulate and interfere with the physiological processes and functions of pathogenic bacteria

Synthesis, Antibacterial Activity, and Mechanisms of Novel Indole Derivatives Containing Pyridinium Moieties

The development of effective antibacterial agents equipped with novel action modes and unique skeletons starting from natural compounds serves as an important strategy in the modern pesticide industry. Disclosed here are a series of novel indole derivatives containing pyridinium moieties and their antibacterial activity evaluation against two prevalent phytopathogenic bacteria, Xanthomonas oryzae pv. oryzicola (Xoc) and X. oryzae pv. oryzae (Xoo). A three-dimensional (3D)-QSAR model was adopted to discover higher activity like title compounds based on the Xoc antibacterial activity of the tested compounds. Compound 43 was consequently designed, and it displayed higher antibacterial activity as expected with the half-maximal effective concentration EC50 values of 1.0 and 1.9 μg/mL for Xoo and Xoc, respectively, which were better than those of the commercial drug thiodiazole copper (TC) (72.9 and 87.5 μg/mL). Under greenhouse conditions, the results of a rice in vivo pot experiment indicated that the protective and curative activities of compound 43 against rice bacterial leaf streak (BLS) and rice bacterial blight (BLB) were 45.0 and 44.0% and 42.0 and 39.3%, respectively, which were better than those of the commercial agent thiodiazole copper (38.0 and 37.9%, 38.6 and 37.0%) as well. Scanning electron microscopy images, defense enzyme activity tests, and proteomic techniques were utilized in a preliminary mechanism study, suggesting that compound 43 shall modulate and interfere with the physiological processes and functions of pathogenic bacteria

Desorption of Polycyclic Aromatic Hydrocarbons on Mesoporous Sorbents: Thermogravimetric Experiments and Kinetics Study

The desorption performances of naphthalene and pyrene on mesoporous MCM-41, SBA-15, and CMK-3 sorbents are studied on the basis of temperature-programmed desorption experiments over the temperature range of 350–800 K at different heating rates. The kinetic parameters for each sorbate–sorbent pair are determined with combined model-fitting methods. The data for naphthalene and pyrene are best fitted with the same kinetic models on MCM-41 (with 1D mesopore channels), in contrast to those on SBA-15 and CMK-3, which have micropore–mesopore structures, leading to different desorption mechanisms for these two sorbates. SBA-15 with interconnectivity between adjacent mesopores not only shows high sorption capacities but also offers diffusion advantages in desorption, which contributes to the order of the degree of ease in desorption: SBA-15 > MCM-41 > CMK-3. CMK-3, with higher microporosity and hydrophobicity, shows stronger binding with the adsorbates while still benefiting in pyrene desorption from the consecutive mesoporosity

Begg’s funnel plot of OPA1 polymorphisms and NTG for allelic model.

<p>A: IVS8+4 T vs C; B:IVS8+32 C vs T. Each circle represents a separate study for the indicated association, and its size is proportional to the sample size of each study.</p