Network Coding Tree Algorithm for Multiple Access System

Network coding is famous for significantly improving the throughput of networks. The successful decoding of the network coded data relies on some side information of the original data. In that framework, independent data flows are usually first decoded and then network coded by relay nodes. If appropriate signal design is adopted, physical layer network coding is a natural way in wireless networks. In this work, a network coding tree algorithm which enhances the efficiency of the multiple access system (MAS) is presented. For MAS, existing works tried to avoid the collisions while collisions happen frequently under heavy load. By introducing network coding to MAS, our proposed algorithm achieves a better performance of throughput and delay. When multiple users transmit signal in a time slot, the mexed signals are saved and used to jointly decode the collided frames after some component frames of the network coded frame are received. Splitting tree structure is extended to the new algorithm for collision solving. The throughput of the system and average delay of frames are presented in a recursive way. Besides, extensive simulations show that network coding tree algorithm enhances the system throughput and decreases the average frame delay compared with other algorithms. Hence, it improves the system performance

A Quadratically Regularized Functional Canonical Correlation Analysis for Identifying the Global Structure of Pleiotropy with NGS Data

Investigating the pleiotropic effects of genetic variants can increase statistical power, provide important information to achieve deep understanding of the complex genetic structures of disease, and offer powerful tools for designing effective treatments with fewer side effects. However, the current multiple phenotype association analysis paradigm lacks breadth (number of phenotypes and genetic variants jointly analyzed at the same time) and depth (hierarchical structure of phenotype and genotypes). A key issue for high dimensional pleiotropic analysis is to effectively extract informative internal representation and features from high dimensional genotype and phenotype data. To explore multiple levels of representations of genetic variants, learn their internal patterns involved in the disease development, and overcome critical barriers in advancing the development of novel statistical methods and computational algorithms for genetic pleiotropic analysis, we proposed a new framework referred to as a quadratically regularized functional CCA (QRFCCA) for association analysis which combines three approaches: (1) quadratically regularized matrix factorization, (2) functional data analysis and (3) canonical correlation analysis (CCA). Large-scale simulations show that the QRFCCA has a much higher power than that of the nine competing statistics while retaining the appropriate type 1 errors. To further evaluate performance, the QRFCCA and nine other statistics are applied to the whole genome sequencing dataset from the TwinsUK study. We identify a total of 79 genes with rare variants and 67 genes with common variants significantly associated with the 46 traits using QRFCCA. The results show that the QRFCCA substantially outperforms the nine other statistics.Comment: 64 pages including 12 figure