QCD4_4 Glueball Masses from AdS-6 Black Hole Description

By using the generalized version of gauge/gravity correspondence, we study the mass spectra of several typical QCD$_4$ glueballs in the framework of AdS$_6$ black hole metric of Einstein gravity theory. The obtained glueball mass spectra are numerically in agreement with those from the AdS$7 \times S^4$ black hole metric of the 11-dimensional supergravity.Comment: 10 pages, references updated and minor change

One-dimensional Ising model built on small-world networks: competing dynamics

In this paper, we offer a competing dynamic analysis of the one-dimensional Ising model built on the small-world network (SWN). Adding-type SWNs are investigated in detail using a simplified Hamiltonian of mean-field nature, and the result of rewiring-type is given because of the similarities of these two typical networks. We study the dynamical processes with competing Glauber mechanism and Kawasaki mechanism. The Glauber-type single-spin transition mechanism with probability p simulates the contact of the system with a heat bath and the Kawasaki-type dynamics with probability 1-p simulates an external energy flux. By studying the phase diagram obtained in the present work, we can realize some dynamical properties influenced by the small-world effect.Comment: 5 pages, one figure, accepted for publication in Physical Review

Structure and stability of quasi-two-dimensional boson-fermion mixtures with vortex-antivortex superposed states

We investigate the equilibrium properties of a quasi-two-dimensional degenerate boson-fermion mixture (DBFM) with a bosonic vortex-antivortex superposed state (VAVSS) using a quantum-hydrodynamic model. We show that, depending on the choice of parameters, the DBFM with a VAVSS can exhibit rich phase structures. For repulsive boson-fermion (BF) interaction, the Bose-Einstein condensate (BEC) may constitute a petal-shaped "core" inside the honeycomb-like fermionic component, or a ring-shaped joint "shell" around the onion-like fermionic cloud, or multiple segregated "islands" embedded in the disc-shaped Fermi gas. For attractive BF interaction just below the threshold for collapse, an almost complete mixing between the bosonic and fermionic components is formed, where the fermionic component tends to mimic a bosonic VAVSS. The influence of an anharmonic trap on the density distributions of the DBFM with a bosonic VAVSS is discussed. In addition, a stability region for different cases of DBFM (without vortex, with a bosonic vortex, and with a bosonic VAVSS) with specific parameters is given.Comment: 8 pages,5 figure

PHLPP Regulates Hexokinase 2-Dependent Glucose Metabolism in Colon Cancer Cells

Increased glucose metabolism is considered as one of the most important metabolic alterations adapted by cancer cells in order to generate energy as well as high levels of glycolytic intermediates to support rapid proliferation. PH domain leucine-rich repeat protein phosphatase (PHLPP) belongs to a novel family of Ser/Thr protein phosphatases that function as tumor suppressors in various types of human cancer. Here we determined the role of PHLPP in regulating glucose metabolism in colon cancer cells. Knockdown of PHLPP increased the rate of glucose consumption and lactate production, whereas overexpression of PHLPP had the opposite effect. Bioenergetic analysis using Seahorse Extracelluar Flux Analyzer revealed that silencing PHLPP expression induced a glycolytic shift in colon cancer cells. Mechanistically, we found that PHLPP formed a complex with Akt and hexokinase 2 (HK2) in the mitochondrial fraction of colon cancer cells and knockdown of PHLPP enhanced Akt-mediated phosphorylation and mitochondrial localization of HK2. Depletion of HK2 expression or treating cells with Akt and HK2 inhibitors reversed PHLPP loss-induced increase in glycolysis. Furthermore, PHLPP knockdown cells became addicted to glucose as a major energy source in that glucose starvation significantly decreased cancer cell survival. As HK2 is the key enzyme that determines the direction and magnitude of glucose flux, our study identified PHLPP as a novel regulator of glucose metabolism by controlling HK2 activity in colon cancer cells

Semi-supervised Adversarial Learning to Generate Photorealistic Face Images of New Identities from 3D Morphable Model

We propose a novel end-to-end semi-supervised adversarial framework to generate photorealistic face images of new identities with wide ranges of expressions, poses, and illuminations conditioned by a 3D morphable model. Previous adversarial style-transfer methods either supervise their networks with large volume of paired data or use unpaired data with a highly under-constrained two-way generative framework in an unsupervised fashion. We introduce pairwise adversarial supervision to constrain two-way domain adaptation by a small number of paired real and synthetic images for training along with the large volume of unpaired data. Extensive qualitative and quantitative experiments are performed to validate our idea. Generated face images of new identities contain pose, lighting and expression diversity and qualitative results show that they are highly constraint by the synthetic input image while adding photorealism and retaining identity information. We combine face images generated by the proposed method with the real data set to train face recognition algorithms. We evaluated the model on two challenging data sets: LFW and IJB-A. We observe that the generated images from our framework consistently improves over the performance of deep face recognition network trained with Oxford VGG Face dataset and achieves comparable results to the state-of-the-art

Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1

AbstractAn important aspect of synapse development is the clustering of neurotransmitter receptors in the postsynaptic membrane. Although MuSK is required for acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ), the underlying molecular mechanisms remain unclear. We report here that in muscle cells, MuSK interacts with Dishevelled (Dvl), a signaling molecule important for planar cell polarity. Disruption of the MuSK-Dvl interaction inhibits Agrin- and neuron-induced AChR clustering. Expression of dominant-negative Dvl1 in postsynaptic muscle cells reduces the amplitude of spontaneous synaptic currents at the NMJ. Moreover, Dvl1 interacts with downstream kinase PAK1. Agrin activates PAK, and this activation requires Dvl. Inhibition of PAK1 activity attenuates AChR clustering. These results demonstrate important roles of Dvl and PAK in Agrin/MuSK-induced AChR clustering and reveal a novel function of Dvl in synapse development

CP violation in Bd,s→l+l−B_{d,s} \to l^+l^- in the model III 2HDM

We have calculated the Wilson coefficients $C_{10}, C_{Q_i}$ (i=1,2) in the $\bar{MS}$ renormalization scheme in the model III 2HDM. Using the obtained Wilson coefficients, we have analyzed the CP violation in decays $B^0_q\to l^+l^-$ (q=d,s) in the model. The CP asymmetry, $A_{CP}$, depends on the parameters of models and $A_{CP}$ in $B_d\to l^+l^-$ can be as large as 40% and 35% for $l=\tau$ and $l=\mu$ respectively. It can reach 4% for $B^0_s$ decays. Because in SM CP violation is smaller than or equal to O($10^{-3}$) which is unobservably small, an observation of CP asymmetry in the decays $B^0_q \to l^+l^- (q=d,s)$ would unambiguously signal the existence of new physics.Comment: revtex4, 16 pages, 7 figure

Epitaxial 2D PbS Nanoplates Arrays with Highly Efficient Infrared Response

2D nonlayered semiconductors attract intense interest due to their unique planar structure and various fascinating optoelectronic properties. Here, a method is developed to design orientation-controlled and well-defined single-crystalline PbS nanoplates arrays on mica. Furthermore, the single PbS nanoplate device displays great photoresponsivity, detectivity, and photo gain values as high as 1621 A W-1, 1.72 x 10(11) Jones, and 2512, respectively

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation

Somatic mutations in acute myeloid leukemia are acquired sequentially and hierarchically. First, pre-leukemic mutations, such as t(8;21) that encodes AML1-ETO, are acquired within the hematopoietic stem cell (HSC) compartment, while signaling pathway mutations, including KRAS activating mutations, are late events acquired during transformation of leukemic progenitor cells and are rarely detectable in HSC. This raises the possibility that signaling pathway mutations are detrimental to clonal expansion of pre-leukemic HSC. To address this hypothesis, we used conditional genetics to introduce Aml1-ETO and K-RasG12D into murine HSC, either individually or in combination. In the absence of activated Ras, Aml1-ETO-expressing HSC conferred a competitive advantage. However, activated K-Ras had a marked detrimental effect on Aml1-ETO-expressing HSC, leading to loss of both phenotypic and functional HSC. Cell cycle analysis revealed a loss of quiescence in HSC co-expressing Aml1-ETO and K-RasG12D, accompanied by an enrichment in E2F and Myc target gene expression and depletion of HSC self-renewal-associated gene expression. These findings provide a mechanistic basis for the observed absence of KRAS signaling mutations in the pre-malignant HSC compartment

Landauer transport model for Hawking radiation from a Reissner-Nordstrom black hole

The recent work of Nation et al in which Hawking radiation energy and entropy flow from a black hole can be regarded as a one-dimensional (1D) Landauer transport process is extended to the case of a Reissner-Nordstrom (RN) black hole. It is found that the flow of charge current can also be transported via a 1D quantum channel except the current of Hawking radiation. The maximum entropy current, which is shown to be particle statistics independence, is also obtained