214 research outputs found
Word-Entity Duet Representations for Document Ranking
This paper presents a word-entity duet framework for utilizing knowledge
bases in ad-hoc retrieval. In this work, the query and documents are modeled by
word-based representations and entity-based representations. Ranking features
are generated by the interactions between the two representations,
incorporating information from the word space, the entity space, and the
cross-space connections through the knowledge graph. To handle the
uncertainties from the automatically constructed entity representations, an
attention-based ranking model AttR-Duet is developed. With back-propagation
from ranking labels, the model learns simultaneously how to demote noisy
entities and how to rank documents with the word-entity duet. Evaluation
results on TREC Web Track ad-hoc task demonstrate that all of the four-way
interactions in the duet are useful, the attention mechanism successfully
steers the model away from noisy entities, and together they significantly
outperform both word-based and entity-based learning to rank systems
Recent Developments in Smart Healthcare
Medicine is undergoing a sector-wide transformation thanks to the advances in computing and networking technologies. Healthcare is changing from reactive and hospital-centered to preventive and personalized, from disease focused to well-being centered. In essence, the healthcare systems, as well as fundamental medicine research, are becoming smarter. We anticipate significant improvements in areas ranging from molecular genomics and proteomics to decision support for healthcare professionals through big data analytics, to support behavior changes through technology-enabled self-management, and social and motivational support. Furthermore, with smart technologies, healthcare delivery could also be made more efficient, higher quality, and lower cost. In this special issue, we received a total 45 submissions and accepted 19 outstanding papers that roughly span across several interesting topics on smart healthcare, including public health, health information technology (Health IT), and smart medicine
Does the Law of One Price hold? A cross-regional study of China
This study considers the price convergence in different regions of
China, which is the largest developing country in the world and a
country in which the regional difference is much larger between
provinces. Whether there is price convergence between regions in one
country is an important economic issue according to the Law of One
Price (LOP) theory. Compared to previous studies, this article operates
with the Sequential Panel Selection Method (SPSM) to explore the
non-stationary properties of the LOP in China’s regions. We provide
robust evidence to specify that the LOP holds true for two-thirds of
the provinces in China, mainly in the Western and Central regions. This
means that the Eastern region’s price fluctuation is non-stationary
and that the consumer price index (CPI) levels of the Western, Central
and Northeastern regions are relatively convergent in China. The
conduction path of the CPI level is from the Eastern region to the other
regions. It shows that prices can converge with each other by LOP and
the values of the same goods in the Western and Central regions are
equal and if there is a price difference, then it can be eliminated by
interregional trade
(1α,2β,3α,7α,11α,13β)-1,3,11-Triacetoxy-2,13-bis(benzyloxy)-7-hydroxy-21-methyl-N,19-secohetisan-19-al
The title compound (delgradine), C41H43NO12, is a hetisine-type C20-diterpenoid alkaloid, isolated from the roots of Aconitum carmichaeli Debx. In the crystal structure, the molecule assumes an U-shaped conformation, the terminal benzene rings being approximately parallel and partially overlapped with each other. The molecule contains eight alicyclic and heterocyclic rings. Cyclohexane rings A and B adopt similar chair conformations; the six-membered rings C, D and E form a bicyclo[2.2.2]octane system with a boat conformation for each six-membered ring, the six-membered heterocyclic ring F has a screw-boat conformation and both of the five-membered rings G and H have envelope conformations. The crystal structure contains intermolecular O—H⋯O hydrogen bonding
Different cerebral plasticity of intrinsic and extrinsic hand muscles after peripheral neurotization in a patient with brachial plexus injury: A TMS and fMRI study
AbstractContralateral C7 (CC7) neurotization has been an important approach for brachial plexus injury (BPI). Patients can achieve relatively good grasping function driven by the proximal extrinsic hand muscle (flexor digitorum, FD) after CC7 neurotization, whereas the thumb opposition function driven by the distal intrinsic muscle (abductor pollicis brevis, APB) is poor. The present study aimed to investigate the brain reorganization patterns of the recovery processes of intrinsic and extrinsic hand functions after repairing the median nerve by CC7 neurotization. Transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) were used to evaluate the cerebral plasticity in one BPI patient after CC7 neurotization. After the CC7 neurotization, the patient showed improvements in the paralyzed hand. Combination of TMS and fMRI investigations demonstrated different cortical reshaping patterns of APB and FD. It was also found that the activated cortical areas of FD were located in bilateral motor cortices, but the area of APB was only located in ipsilateral motor cortex. The cerebral plasticity procedure appeared to be different in the gross and fine motor function recovery processes. It provided a new perspective into the cerebral plasticity induced by CC7 neurotization
IL21R and PTH May Underlie Variation of Femoral Neck Bone Mineral Density as Revealed by a Genome-wide Association Study
Bone mineral density (BMD) measured at the femoral neck (FN) is the most important risk phenotype for osteoporosis and has been used as a reference standard for describing osteoporosis. The specific genes influencing FN BMD remain largely unknown. To identify such genes, we first performed a genome-wide association (GWA) analysis for FN BMD in a discovery sample consisting of 983 unrelated white subjects. We then tested the top significant single-nucleotide polymorphisms (SNPs; 175 SNPs with p < 5 × 10−4) for replication in a family-based sample of 2557 white subjects. Combing results from these two samples, we found that two genes, parathyroid hormone (PTH) and interleukin 21 receptor (IL21R), achieved consistent association results in both the discovery and replication samples. The PTH gene SNPs, rs9630182, rs2036417, and rs7125774, achieved p values of 1.10 × 10−4, 3.24 × 10−4, and 3.06 × 10−4, respectively, in the discovery sample; p values of 6.50 × 10−4, 5.08 × 10−3, and 5.68 × 10−3, respectively, in the replication sample; and combined p values of 3.98 × 10−7, 9.52 × 10−6, and 1.05 × 10−5, respectively, in the total sample. The IL21R gene SNPs, rs8057551, rs8061992, and rs7199138, achieved p values of 1.51 × 10−4, 1.53 × 10−4, and 3.88 × 10−4, respectively, in the discovery sample; p values of 2.36 × 10−3, 6.74 × 10−3, and 6.41 × 10−3, respectively, in the replication sample; and combined p values of 2.31 × 10−6, 8.62 × 10−6, and 1.41 × 10−5, respectively, in the total sample. The effect size of each SNP was approximately 0.11 SD estimated in the discovery sample. PTH and IL21R both have potential biologic functions important to bone metabolism. Overall, our findings provide some new clues to the understanding of the genetic architecture of osteoporosis. © 2010 American Society for Bone and Mineral Research
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