Angular BN-Heteroacenes with <i>syn</i>-Structure-Induced Promising Properties as Host Materials of Blue Organic Light-Emitting Diodes

A series of novel angular BN-heteroacenes were successfully synthesized. Associated with the intrinsic <i>syn</i>-structures, they exhibit unique molecular alignments in a solid state and promising electronic properties, and are thus suitable as efficient nondoped emitters for the fabrication of blue organic light-emitting diodes with improved performance

Angular BN-Heteroacenes with <i>syn</i>-Structure-Induced Promising Properties as Host Materials of Blue Organic Light-Emitting Diodes

A series of novel angular BN-heteroacenes were successfully synthesized. Associated with the intrinsic <i>syn</i>-structures, they exhibit unique molecular alignments in a solid state and promising electronic properties, and are thus suitable as efficient nondoped emitters for the fabrication of blue organic light-emitting diodes with improved performance

Triple Boron-Cored Chromophores Bearing Discotic 5,11,17-Triazatrinaphthylene-Based Ligands

A series of novel chromophores fused with multiple boron cores have been successfully synthesized by the complexation of three difluoroboryl or diphenylboryl at the periphery of 5,11,17-triazatrinaphthylene derivative ligands. Their sterically congested molecular scaffolds with expanded π-conjugated discotic backbones render them with unique electronic properties including large Stokes shifts, tunable electrochemical behaviors, and low-lying LUMO energy levels up to −3.18 eV

Tetrandrine inhibits migration and invasion of human renal cell carcinoma by regulating Akt/NF-κB/MMP-9 signaling

<div><p>Renal cell carcinoma (RCC) is known as one of the most lethal malignancies in the urological system because of its high incidence of metastasis. Tetrandrine (Tet), a traditional Chinese herbal medicine, exerts a potent anti-cancer effect in a variety of cancer cells. However, the anti-metastatic effect of Tet and its possible mechanism in RCC is still unclear. The present study revealed that Tet significantly suppressed the migration and invasion of RCC 786-O and 769-P cells <i>in vitro</i>. Mechanistically, the protein levels of matrix metalloproteinases 9 (MMP-9), phosphorylated PI3K, PDK1, Akt and NF-κB were markedly reduced after Tet treatment. Moreover, co-treatment with LY294002 (PI3K inhibitor) could further enhance the Tet-inhibited migration and invasion, and the NF-κB and MMP-9 protein levels were further decreased. Similar results were observed after PDTC (NF-κB inhibitor) co-treatment. Conversely, SC79, an Akt activator, could partially reverse the anti-metastatic effects of Tet, accompanied by the restoration of NF-κB and MMP-9 protein levels. In conclusion, the current results indicated that Tet inhibited migration and invasion of RCC partially by regulating Akt/NF-κB/MMP-9 signaling pathway, suggesting that Tet may be a potential therapeutic candidate against metastatic RCC.</p></div

Enhancement of Low-Temperature Catalytic Activity over a Highly Dispersed Fe–Mn/Ti Catalyst for Selective Catalytic Reduction of NO_<i>x</i> with NH₃

A novel Fe₂O₃–MnO₂/TiO₂ catalyst was synthesized using a conventional impregnation method assisted with ethylene glycol and used for NH₃–SCR. The catalyst exhibited superior low-temperature activity over a broad temperature window (100–325 °C), low apparent activation energy, and excellent sulfur-poisoning resistance. The characterization results revealed that the catalyst was greatly dispersed with smaller particles, and the partial doping of Fe into the TiO₂ lattice thereby led to the formation of the Fe–O–Ti structure, which could strengthen the electronic inductive effect and increase the ratio of surface chemisorption oxygen, resulting in the enhancement of NO oxidation and favoring the low-temperature SCR activity via a “fast SCR” process. The in situ FTIR analysis showed that the NO_<i>x</i> adsorption capacity was significantly improved due to the desired dispersion property, further helping both the SCR activity and reaction rate at low temperatures. The present work confirmed that more active sites can be provided on the catalyst surface by modifying the dispersity

Synthesis and Properties of <i>C</i>_<i>2h</i>-Symmetric BN-Heteroacenes Tailored through Aromatic Central Cores

The 2-fold successive electrophilic borylation on one aromatic central core led to a series of <i>C</i>_<i>2h</i>-symmetric BN-heteroacenes in excellent yields. For the first time, we introduced trimethylsilyl (TMS) as either leaving group or oriented group for efficiently improving the preparation of BN-embedded polycyclic aromatic hydrocarbons (PAHs). The physical properties of the as-synthesized BN-heteroacenes in either solid state or solution can be finely tuned through the position isomerization or the fused ring numbers of the aromatic central core

Synthesis and Properties of <i>C</i>_<i>2h</i>-Symmetric BN-Heteroacenes Tailored through Aromatic Central Cores

The 2-fold successive electrophilic borylation on one aromatic central core led to a series of <i>C</i>_<i>2h</i>-symmetric BN-heteroacenes in excellent yields. For the first time, we introduced trimethylsilyl (TMS) as either leaving group or oriented group for efficiently improving the preparation of BN-embedded polycyclic aromatic hydrocarbons (PAHs). The physical properties of the as-synthesized BN-heteroacenes in either solid state or solution can be finely tuned through the position isomerization or the fused ring numbers of the aromatic central core

Inductive Effect Boosting Catalytic Performance of Advanced Fe_1<i>–x</i>V_<i>x</i>O_δ Catalysts in Low-Temperature NH₃ Selective Catalytic Reduction: Insight into the Structure, Interaction, and Mechanisms

A series of vanadium doped Fe₂O₃ catalysts were synthesized using the homogeneous precipitation method and subjected to laboratory evaluation for selective catalytic reduction of NO_<i>x</i> with NH₃ (NH₃-SCR). The best Fe_0.75V_0.25O_δ catalyst with a Fe/V mole ratio of 3/1 exhibited superior catalytic performance, achieving 100% NO_<i>x</i> conversion at 200 °C over a wide temperature window from 175 to 400 °C, believed to be the best Fe-based low-temperature NH₃-SCR catalyst identified to date. The Fe_0.75V_0.25O_δ catalyst also showed prominent resistance to high gas hourly space velocity (GHSV; 200 000 h^–1) and strong durability to SO₂ and H₂O. Doping of V was shown to remarkably boost the catalytic activity, due to enhancement of the redox ability and surface acidity. XRD, Raman, and morphology results revealed that the incorporation of V had led to the formation of amorphous FeVO₄ and Fe₂O₃. Coupling XPS and UV–vis diffuse reflectance spectra (DRS) results with DFT, it was discovered that the electron inductive effect between Fe and V generated the charge depletion of Fe, resulting in an improvement of the redox ability, facilitating the oxidation of NO to NO₂. Meanwhile, the strong interaction between FeVO₄ and Fe₂O₃ species kept V at a higher valence, beneficial for the adsorption and activation of NH₃. The synergistic effect of FeVO₄ and Fe₂O₃ thus improved the low-temperature catalytic activity and lowered the apparent activation energy. Combining <i>in situ</i> diffusion Fourier transform infrared spectroscopy (DRIFTS) results with reaction kinetic studies, it was concluded that the SCR reaction mainly followed the Langmuir–Hinshelwood mechanism below 200 °C, since the consumption of adsorbed NH₃ species could be divided into the explicit “standard SCR” and “fast SCR” stages, while an Eley–Rideal mechanism proceeded dominantly at and above 200 °C, in which the adsorbed NH₃ species were eliminated by gaseous NO directly and linearly. Both the Brønsted and Lewis acid sites played equivalently significant roles in NH₃-SCR reaction

Ladder-Type BN-Embedded Heteroacenes with Blue Emission

Using a concise synthetic strategy, a series of novel ladder-type BN-embedded heteroacenes were successfully synthesized. Their molecular skeletons render the versatile modification which is desirable for achieving unique physical properties. Organic light-emitting diode devices based on BN-embedded heteroacenes were subsequently fabricated, demonstrating their promising application as blue emitters

Tet represses cell migration and invasion of human RCC by negatively regulating NF-κB expression.

<p>The metastatic phenotype of 786-O and 769-P was determined by transwell assay. The migrated and invaded 786-O (<b>A)</b> and 769-P (<b>B</b>) cells were counted after treatment with Tet (0.5μM), PDTC (10μM), or the both for 24 h. Under similar treatment, lysates from 786-O (<b>C</b>) and 769-P (<b>D</b>) cells treated with Tet or PDTC were immunoblotted for MMP-9 and NF-κB. All the experiments were performed in triplicate. Representative results from three independent experiments were shown.</p