Study on the Relationship between “Modern Social Development” and “Human Development” in Marxist Perspective

Modern social development and human development are intrinsically linked. It is widely recognized, especially by Marxists, that the progress of modern society and the development of human beings are mutually influential, mutually reinforcing and internally unified. Based on the Marxist perspective, this paper studies the relationship between modern social development and human development on the theoretical basis of the concept of human development, especially elaborates on a series of major theoretical and practical issues in the process of modernization and development, with a view to grasping the philosophical laws of modern social development and putting forward constructive opinions in accordance with the laws, thus promoting the free and comprehensive development of human beings

"Are You Really Sure?" Understanding the Effects of Human Self-Confidence Calibration in AI-Assisted Decision Making

In AI-assisted decision-making, it is crucial but challenging for humans to achieve appropriate reliance on AI. This paper approaches this problem from a human-centered perspective, "human self-confidence calibration". We begin by proposing an analytical framework to highlight the importance of calibrated human self-confidence. In our first study, we explore the relationship between human self-confidence appropriateness and reliance appropriateness. Then in our second study, We propose three calibration mechanisms and compare their effects on humans' self-confidence and user experience. Subsequently, our third study investigates the effects of self-confidence calibration on AI-assisted decision-making. Results show that calibrating human self-confidence enhances human-AI team performance and encourages more rational reliance on AI (in some aspects) compared to uncalibrated baselines. Finally, we discuss our main findings and provide implications for designing future AI-assisted decision-making interfaces

Case report: Dual-targeted BCMA and CS1 CAR-T-cell immunotherapy in recurrent and refractory extramedullary multiple myeloma

BackgroundThe development of CAR-T-cell immunotherapy has notably elevated the efficacy of treating multiple myeloma. Currently, a variety of targets, including BCMA, CS1, CD38, FcRH5, and GPRC5D, are being investigated. Despite these significant advancements, challenges such as antigen escape, limited persistence of CAR-T cells, and the intricate nature of the tumor microenvironment persist, leading to relapses following treatment.Case presentationWe report the case of a patient with recurrent and refractory multiple myeloma (RRMM) who developed a substantial extramedullary plasmacytoma in the muscles of the lower limb following multiple rounds of radiotherapy and chemotherapy. The patient underwent CAR-T-cell immunotherapy targeting BCMA and CS1; however, the tumor progressed despite treatment. Surgical resection of the extramedullary plasmacytoma was subsequently performed. Upon comparison of the tumor tissue with the adjacent tissue, increased expression of MYBL2 was noted in the tumor tissue, potentially contributing to the lack of improvement in extramedullary relapse after dual-targeted CAR-T cell therapy.ConclusionsIn patients with recurrent and refractory multiple myeloma who underwent multiple cycles of chemotherapy and radiotherapy, dual-targeted CAR-T cell therapy aimed at BCMA and CS1 failed to effectively manage extramedullary relapse. Elevated expression of MYBL2 in multiple myeloma correlates with a poorer prognosis

Interactions between Exposure to Environmental Polycyclic Aromatic Hydrocarbons and DNA Repair Gene Polymorphisms on Bulky DNA Adducts in Human Sperm

BACKGROUND: Nucleotide excision repair (NER) and base excision repair (BER) are the primary mechanisms for repair of bulky adducts caused by chemical agents, such as PAHs. It is expected that polymorphisms in NER or BER genes may modulate individual susceptibility to PAHs exposure. Here, we evaluate the effects of PAHs exposure and polymorphisms in NER and BER pathway, alone or combined, on polycyclic aromatic hydrocarbon-DNA (PAH-DNA) adducts in human sperm. METHODOLOGY/PRINCIPAL FINDINGS: Sperm PAH-DNA adducts were measured by immunofluorescent assay using flow cytometry in a sample of 465 infertile adults. Polymorphisms of XPA, XPD, ERCC1, XPF, and XRCC1 were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques. The PAHs exposure was detected as urinary 1-hydroxypyrene (1-OHP) levels. In multivariate models adjusted for potential confounders, we observed that XRCC1 5'pUTR -T/C, Arg194Trp, Arg399Gln polymorphisms were associated with increased sperm adduct levels. Furthermore, the stratified analysis indicated that adverse effects of XRCC1 Arg194Trp, Arg399Gln polymorphisms on PAH-DNA adducts were detected only in the high PAHs exposure group. CONCLUSIONS/SIGNIFICANCE: These findings provided the first evidence that polymorphisms of XRCC1 may modify sperm PAH-DNA adduct levels and may be useful biomarkers to identify individuals susceptible to DNA damage resulting from PAHs exposure

Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy

Repurposing old antibiotics into more effective and safer formulations is an emergent approach to tackle the growing threat of antimicrobial resistance. Herein, a peptide hydrogel is reported for the localized and sustained release of polymyxin B (PMB), a decade-old antibiotic with increasing clinical utility for treating multidrug-resistant Gram-negative bacterial infections. The hydrogel is assembled by additing PMB solution into a rationally designed peptide amphiphile (PA) solution and its mechanical properties can be adjusted through the addition of counterions, envisioning its application in diverse infection scenarios. Sustained release of PMB from the hydrogel over a 5-day period and prolonged antimicrobial activities against Gram-negative bacteria are observed. The localized release of active PMB from the hydrogel is shown to be effective in vivo for treating Pseudomonas aeruginosa infection in the Galleria mellonella burn wound infection model, dramatically reducing the mortality from 93% to 13%. Complementary antimicrobial activity against Gram-positive Staphylococcus aureus and enhanced antimicrobial effect against the Gram-negative Acinetobacter baumannii are observed when an additional antibiotic fusidic acid is incorporated into the hydrogen network. These results demonstrate the potential of the PMB-triggered PA hydrogel as a versatile platform for the localized and sustained delivery of combined antimicrobial therapies

Twofold Symmetry Observed in Bi2_{2}Te3_{3}/FeTe Interfacial Superconductor

Superconducting pairing symmetry are crucial in understanding the microscopic superconducting mechanism of a superconductor. Here we report the observation of a twofold superconducting gap symmetry in an interfacial superconductor Bi$_{2}$Te$_{3}$/FeTe, by employing quasiparticle interference (QPI) technique in scanning tunneling microscopy and macroscopic magnetoresistance measurements. The QPI patterns corresponding to energies inside and outside the gap reveal a clear anisotropic superconducting gap. Furthermore, both the in-plane angle-dependent magnetoresistance and in-plane upper critical field exhibit a clear twofold symmetry. This twofold symmetry align with the Te-Te direction in FeTe, which weakens the possible generation by bi-collinear antiferromagnetism order. Our finding provides key information in further understanding of the topological properties in Bi$_{2}$Te$_{3}$/FeTe superconducting system and propels further theoretical interests in the paring mechanism in the system

Millennial-scale variations in sedimentary oxygenation in the western subtropical North Pacific and its links to North Atlantic climate

The deep-ocean carbon cycle, especially carbon sequestration and outgassing, is one of the mechanisms to explain variations in atmospheric CO2 concentrations on millennial and orbital timescales. However, the potential role of subtropical North Pacific subsurface waters in modulating atmospheric CO2 levels on millennial timescales is poorly constrained. An increase in the respired CO2 concentration in the glacial deep-ocean due to biological pump generally corresponds to deoxygenation in the ocean interior. This link thus offers a chance to study oceanic ventilation and coeval export productivity based on redox-controlled sedimentary geochemical parameters. Here, we investigate a suite of geochemical proxies in a sediment core from the Okinawa Trough to understand sedimentary oxygenation variations in the subtropical North Pacific over the last 50 000 years (50 ka). Our results suggest that enhanced mid-depth western subtropical North Pacific (WSTNP) sedimentary oxygenation occurred during cold intervals and after 8.5 ka, while oxygenation decreased during the Bölling-Alleröd (B/A) and Preboreal. The enhanced oxygenation during cold spells is linked to the North Pacific IntermediateWater (NPIW), while interglacial increase after 8.5 ka is linked to an intensification of the Kuroshio Current due to strengthened northeast tradewinds over the tropics. The enhanced formation of the NPIW during Heinrich Stadial 1 (HS1) was likely driven by the perturbation of sea ice formation and sea surface salinity oscillations in the high-latitude North Pacific. The diminished sedimentary oxygenation during the B/A due to a decreased NPIW formation and enhanced export production, indicates an expansion of the oxygen minimum zone in the North Pacific and enhanced CO2 sequestration at mid-depth waters, along with the termination of atmospheric CO2 concentration increase. We attribute the millennial-scale changes to an intensified NPIW and enhanced abyss flushing during deglacial cold and warm intervals, respectively, closely related to variations in North Atlantic Deep Water formation

Genome-wide analysis of the GRAS gene family in Liriodendron chinense reveals the putative function in abiotic stress and plant development

IntroductionGRAS genes encode plant-specific transcription factors that play essential roles in plant growth and development. However, the members and the function of the GRAS gene family have not been reported in Liriodendron chinense. L. chinense, a tree species in the Magnolia family that produces excellent timber for daily life and industry. In addition, it is a good relict species for plant evolution research.MethodsTherefore, we conducted a genome-wide study of the LcGRAS gene family and identified 49 LcGRAS genes in L. chinense.ResultsWe found that LcGRAS could be divided into 13 sub-groups, among which there is a unique branch named HAM-t. We carried out RNA sequencing analysis of the somatic embryos from L. chinense and found that LcGRAS genes are mainly expressed after heart-stage embryo development, suggesting that LcGRAS may have a function during somatic embryogenesis. We also investigated whether GRAS genes are responsive to stress by carrying out RNA sequencing (RNA-seq) analysis, and we found that the genes in the PAT subfamily were activated upon stress treatment, suggesting that these genes may help plants survive stressful environments. We found that PIF was downregulated and COR was upregulated after the transient overexpression of PATs, suggesting that PAT may be upstream regulators of cold stress. DiscussionCollectively, LcGRAS genes are conserved and play essential roles in plant development and adaptation to abiotic stress

Halophyte Nitraria billardieri CIPK25 promotes photosynthesis in Arabidopsis under salt stress

The calcineurin B-like (CBL)-interacting protein kinases (CIPKs), a type of plant-specific genes in the calcium signaling pathway, function in response to adverse environments. However, few halophyte derived CIPKs have been studied for their role in plant physiological and developmental adaptation during abiotic stresses, which inhibits the potential application of these genes to improve environmental adaptability of glycophytes. In this study, we constructed Nitraria billardieri CIPK25 overexpressing Arabidopsis and analyzed the seedling development under salt treatment. Our results show that Arabidopsis with NbCIPK25 expression exhibits more vigorous growth than wild type plants under salt condition. To gain insight into the molecular mechanisms underlying salt tolerance, we profiled the transcriptome of WT and transgenic plants via RNA-seq. GO and KEGG analyses revealed that upregulated genes in NbCIPK25 overexpressing seedlings under salt stress are enriched in photosynthesis related terms; Calvin-cycle genes including glyceraldehyde-3-phosphate dehydrogenases (GAPDHs) are significantly upregulated in transgenic plants, which is consistent with a decreased level of NADPH (GAPDH substrate) and increased level of NADP+. Accordingly, NbCIPK25 overexpressing plants exhibited more efficient photosynthesis; soluble sugar and proteins, as photosynthesis products, showed a higher accumulation in transgenic plants. These results provide molecular insight into how NbCIPK25 promotes the expression of genes involved in photosynthesis, thereby maintaining plant growth under salt stress. Our finding supports the potential application of halophyte-derived NbCIPK25 in genetic modification for better salt adaptation

Modified tibial cortex transverse transport for diabetic foot ulcers with Wagner grade ≥ II: a study of 98 patients

BackgroundDiabetic foot ulcers constitute a substantial healthcare burden on a global scale and present challenges in achieving healing. Our objective was to assess the efficacy of modified tibial cortex transverse transport surgery in managing refractory diabetic foot ulcers.MethodsWe retrospectively analyzed clinical data from 98 patients suffering from diabetic foot ulcers classified as Wagner grade ≥II who were admitted to our medical facility between January 2020 and June 2022. All the patients were treated by modified tibial cortex transverse transport surgery, wherein the osteotomy scope was reduced to two rectangular bone windows measuring 1.5cm × 1.5cm each. Record the patient’s general information and ulcer healing time; ulcer area, ankle-brachial index, WIFi classification, and visual analogue scale before and 3 months following the surgical intervention.ResultsThe average duration of diabetes of 98 patients with diabetic foot ulcer was 20.22 ± 8.02 years, 52 patients had more than one toe gangrene on admission. The postoperative wound healing rate was 95.83% and the average healing time was 53.18 ± 20.18 days. The patients showed significant improvement in ankle-brachial index, WIFi classification, and visual analogue scale at 3 months postoperatively compared to preoperatively, with statistically significant differences (P< 0.05). Eight patients experienced complications, and the incidence of complications was 8.16%. Throughout the follow-up period, there were no instances of ulcer recurrence noted.ConclusionModified tibial cortex transverse transport surgery demonstrates effectiveness in the management of diabetic foot ulcers by enhancing lower limb microcirculation and facilitating the process of wound healing