Vacancy expansion in alpha-Ti under tensile loads at different strain rates with MD simulation

In order to analyze the effect of strain rate under tensile load on microcrack growth in Alpha Titanium, molecular dynamics simulation was used to analyze the results of atomic location, dislocation distribution, lattice phase transition, potential energy distribution and volume strain distribution. It was found that the cracks gradually evolved into holes after unstable propagation, and the holes were occupied by clusters on both sides of the material in the later stage under the necking of the material. The higher the tensile strain rate, the earlier the crack initiation and the larger the evolution of the through-hole. When the same strain value is reached, the lattice transformation ratio is higher under high strain rate loading. HCP is transformed into amorphous structure, BCC lattice type and a small amount of FCC type. Moreover, the larger the strain rate, the less the compatible deformation ability of the lattice is, and the more twins are produced. In addition, it is found that there are volumetric strain wave emission and diffusion in the model at the moment of void birth, and voids play a role in dividing the energy absorption region. Dislocation emission occurs at the crack tip and energy competition exists between dislocation and crack propagation

The research of polishing nozzle quality based on discrete element method

In order to get further study for the effect of abrasive grains to the wall of the workpiece during polishing process, a new method of discrete element that carry out the numerical simulation with DEM is put forward, and the visual calculation is performed for the abrasive grain movement in the nozzle. The interaction of particles-particles or particles-workpiece wall during the polishing process and the tracks of single grain in the workpiece are analyzed by observing the distribution of abrasive grain in the workpiece at different time. The surface removal mechanism of abrasive grains to the workpiece material is discussed by analyzing the collision process of particles to the workpiece wall. The wear level of the abrasive grains to the inner surface of the workpiece is studied through the force of abrasive grain to the workpiece wall consumption, and finally explore the cutting effect of particles to workpiece wall. As a consequence, the abrasive flow processing experiment is carried out. The surface roughness of the large hole and small hole of the nozzle are detected by stylus measurement. The conclusion shows that the surface roughness for the large hole and the small hole before the experiment is1.741 μm and 1.201 μm, its 0.801 μm, 0.651 μm after it. Further roughness tests are performed on the surface of the pores by means of a grating surface measuring instrument. The result indicates that the surface roughness reduces from 2.67 μm to 0.697 μm, 0.728 μm, 0.782 μm. Apparently, the surface roughness of the hole is sharply reduced, which has a smooth and flat inner surface, the effectiveness and reliability of the abrasive flow are verified

18F-labeled FGFR1 peptide: a new PET probe for subtype FGFR1 receptor imaging

IntroductionThe fibroblast growth factor receptor (FGFR) family is highly expressed in a variety of tumor types and represents a new target for cancer therapy. Different FGFR subtype aberrations have been found to exhibit highly variable sensitivity and efficacy to FGFR inhibitors.MethodsThe present study is the first to suggest an imaging method for assessing FGFR1 expression. The FGFR1-targeting peptide NOTA-PEG2-KAEWKSLGEEAWHSK was synthesized by manual solid-phase peptide synthesis and high-pressure liquid chromatography (HPLC) purification and then labeled with fluorine-18 using NOTA as a chelator. In vitro and in vivo experiments were conducted to evaluate the stability, affinity and specificity of the probe. Tumor targeting efficacy and biodistribution were evaluated by micro-PET/CT imaging in RT-112, A549, SNU-16 and Calu-3 xenografts.ResultsThe radiochemical purity of [18F]F-FGFR1 was 98.66% ± 0.30% (n = 3) with excellent stability. The cellular uptake rate of [18F]F-FGFR1 in the RT-112 cell line (FGFR1 overexpression) was higher than that in the other cell lines and could be blocked by the presence of excess unlabeled FGFR1 peptide. Micro-PET/CT imaging revealed a significant concentration of [18F]F-FGFR1 in RT-112 xenografts with no or very low uptake in nontargeted organs and tissues, which demonstrated that [18F]F-FGFR1 was selectively taken up by FGFR1-positive tumors.Conclusion[18F]F-FGFR1 showed high stability, affinity, specificity and good imaging capacity for FGFR1-overexpressing tumors in vivo, which provides new application potential in the visualization of FGFR1 expression in solid tumors

2-Hydr­oxy-1-methoxyxanthen-9-one monohydrate

In the title compound, C14H10O4·H2O, isolated from the roots of Calophyllum membranaceum, the xanthene ring system is almost planar (r.m.s. deviation = 0.008 Å). In the crystal structure, inter­molecular O—H⋯O and O—H⋯(O,O) hydrogen bonds connect the mol­ecules