Recurrent Multi-scale Transformer for High-Resolution Salient Object Detection

Salient Object Detection (SOD) aims to identify and segment the most conspicuous objects in an image or video. As an important pre-processing step, it has many potential applications in multimedia and vision tasks. With the advance of imaging devices, SOD with high-resolution images is of great demand, recently. However, traditional SOD methods are largely limited to low-resolution images, making them difficult to adapt to the development of High-Resolution SOD (HRSOD). Although some HRSOD methods emerge, there are no large enough datasets for training and evaluating. Besides, current HRSOD methods generally produce incomplete object regions and irregular object boundaries. To address above issues, in this work, we first propose a new HRS10K dataset, which contains 10,500 high-quality annotated images at 2K-8K resolution. As far as we know, it is the largest dataset for the HRSOD task, which will significantly help future works in training and evaluating models. Furthermore, to improve the HRSOD performance, we propose a novel Recurrent Multi-scale Transformer (RMFormer), which recurrently utilizes shared Transformers and multi-scale refinement architectures. Thus, high-resolution saliency maps can be generated with the guidance of lower-resolution predictions. Extensive experiments on both high-resolution and low-resolution benchmarks show the effectiveness and superiority of the proposed framework. The source code and dataset are released at: https://github.com/DrowsyMon/RMFormer.Comment: This work is accepted by ACM MM2023. More modifications may be performed for further improvement

A Bioinspired and Biocompatible ortho-sulfiliminyl phenol Synthesis

Synthetic methods inspired by Nature often offer unique advantages including mild conditions and biocompatibility with aqueous media. Inspired by an ergothioneine biosynthesis protein EgtB, a mononuclear non-haem iron enzyme capable of catalysing the C–S bond formation and sulfoxidation, herein, we discovered a mild and metal-free C–H sulfenylation/intramolecular rearrangement cascade reaction employing an internally oxidizing O–N bond as a directing group. Our strategy accommodates a variety of oxyamines with good site selectivity and intrinsic oxidative properties. Combining an O–N bond with an X–S bond generates a C–S bond and an S¼N bond rapidly. The newly discovered cascade reaction showed excellent chemoselectivity and a wide substrate scope for both oxyamines and sulfenylation reagents. We demonstrated the biocompatibility of the C–S bond coupling reaction by applying a coumarin-based fluorogenic probe in bacterial lysates. Finally, the C–S bond coupling reaction enabled the first fluorogenic formation of phospholipids, which self-assembled to fluorescent vesicles in situ

Advances in novel biomaterials combined with traditional Chinese medicine rehabilitation technology in treatment of peripheral nerve injury

Peripheral nerve injuries (PNI) represent one of the primary neuropathies leading to lifelong disability. Nerve regeneration and targeted muscle atrophy stand as the two most crucial factors influencing functional rehabilitation post peripheral nerve injury. Over time, traditional Chinese medicine (TCM) rehabilitation approaches such as acupuncture, Tuina, and microneedles serve as pivot means to activate the regeneration of injured nerve Schwann cells. By promoting axon regeneration, these approaches can accomplish nerve repair, reconstruction, and functional rehabilitation. Although TCM rehabilitation approaches have clinically demonstrated effectiveness in promoting the repair and regeneration of PNI, the related molecular mechanisms remain unclear. This significantly hampers the application and promotion of TCM rehabilitation in PNI recovery. Therefore, deeply delving into the cellular and molecular mechanisms of TCM rehabilitation technologies to foster nerve regeneration stands as the most pressing issue. On the other hand, in recent years, novel biomaterials represented by hydrogels, microfluidic platforms, and new chitosan scaffolds have showed their unique roles in treating various degrees of nerve injury. These methods exhibit immense potential in conducting high-throughput cell and organoid culture in vitro and synthesizing diverse tissue engineering scaffolds and drug carriers. We believe that the combination of TCM rehabilitation technology and novel biomaterials can more effectively address precise treatment issues such as identification of treatment target and dosage control. Therefore, this paper not only summarizes the molecular mechanisms of TCM rehabilitation technology and novel biomaterials in treating peripheral nerve injury individually, but also explores the research direction of precise treatment by integrating the two at both macro and micro levels. Such integration may facilitate the exploration of cellular and molecular mechanisms related to neurodegeneration and regeneration, providing a scientific and theoretical foundation for the precise functional rehabilitation of PNI in the future

Doping High-Mobility Donor : Acceptor Copolymer Semiconductors with an Organic Salt for High-Performance Thermoelectric Materials

Organic semiconductors (OSCs) are attractive for fabrication of thermoelectric devices with low cost, large area, low toxicity, and high flexibility. In order to achieve high-performance organic thermoelectric devices (OTEs), it is essential to develop OSCs with high conductivity (σ), large Seebeck coefficient (S), and low thermal conductivity (κ). It is equally important to explore efficient dopants matching the need of thermoelectric devices. The thermoelectric performance of a high-mobility donor–acceptor (D–A) polymer semiconductor, which is doped by an organic salt, is studied. Both a high p-type electrical conductivity approaching 4 S cm−1 and an excellent power factor (PF) of 7 µW K−2 m−1 are obtained, which are among the highest reported values for polymer semiconductors. Temperature-dependent conductivity, Seebeck coefficient and power factor of the doped materials are systematically investigated. Detailed analysis on the results of thermoelectric measurements has revealed a hopping transport in the materials, which verifies the empirical relationship: S ∝ σ−1/4 and PF ∝ σ1/2. The results demonstrate that D–A copolymer semiconductors with proper combination of dopants have great potential for fabricating high-performance thermoelectric devices. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei

Murine model of elastase-induced proximal thoracic aortic aneurysm through a midline incision in the anterior neck

ObjectiveThis study was performed to develop a murine model of elastase-induced proximal thoracic aortic aneurysms (PTAAs).MethodsThe ascending thoracic aorta and aortic arch of adult C57BL/6J male mice were exposed through a midline incision in the anterior neck, followed by peri-adventitial elastase or saline application. The maximal ascending thoracic aorta diameter was measured with high-resolution micro-ultrasound. Twenty-eight days after the operation, the aortas were harvested and analyzed by histopathological examination and qualitative polymerase chain reaction to determine the basic characteristics of the aneurysmal lesions.ResultsFourteen days after the operation, the dilation rate (mean ± standard error) in the 10-min elastase application group (n = 10, 71.44 ± 10.45%) or 5-min application group (n = 9, 42.67 ± 3.72%) were significantly higher than that in the saline application group (n = 9, 7.37 ± 0.94%, P < 0.001 for both). Histopathological examination revealed aortic wall thickening, degradation of elastin fibers, loss of smooth muscle cells, more vasa vasorum, enhanced extracellular matrix degradation, augmented collagen synthesis, upregulated apoptosis and proliferation capacity of smooth muscle cells, and increased macrophages and CD4+ T cells infiltration in the PTAA lesions. Qualitative analyses indicated higher expression of the proinflammatory markers, matrix metalloproteinase-2 and -9 as well as Collagen III, Collagen I in the PTAAs than in the controls.ConclusionWe established a novel in vivo mouse model of PTAAs through a midline incision in the anterior neck by peri-adventitial application of elastase. This model may facilitate research into the pathogenesis of PTAA formation and the treatment strategy for this devastating disease

Tembusu Virus in Ducks, China

In China in 2010, a disease outbreak in egg-laying ducks was associated with a flavivirus. The virus was isolated and partially sequenced. The isolate exhibited 87%–91% identity with strains of Tembusu virus, a mosquito-borne flavivirus of the Ntaya virus group. These findings demonstrate emergence of Tembusu virus in ducks

Performance of Impregnated Paper Decorated Blockboard Manufactured Using HDF as Equilibrium Layer

In order to further improve the performance of impregnated paper decorated blockboard (ecological board), high-density fiberboard (HDF) was selected as the equilibrium layer to replace the commonly used poplar veneer. Results showed that the performance of HDF ecological board can be comparable to that of poplar veneer ecological board. It had good appearance quality, and its surface scratch resistance, surface wear resistance, water resistance and mechanical properties met the requirements of National Standard GB/T 34722-2017. The surface cracking resistance of the ecological board prepared with HDF as the equilibrium layer reached the highest level (grade 5), far better than that of the poplar veneer ecological board. This was because HDF was a relatively homogeneous material, and its dry shrinkage in both the transverse direction and along the grain direction was much lower than that of the poplar veneer. This characteristic of HDF made it possible to improve the dimensional stability and bending resistance of blockboard substrates under dry and hot conditions. The formaldehyde emission of the HDF ecological board was higher than that of the poplar veneer ecological board, but it met the formaldehyde emission requirements of indoor materials according to GB 18580-2001

Research Progress of Wood-Based Panels Made of Thermoplastics as Wood Adhesives

When thermoplastic resins such as polyethylene (PE) and polypropylene (PP) are selected as wood adhesives to bond wood particles (fibers, chips, veneers) by using the hot-pressing technique, the formaldehyde emission issue that has long existed in the wood-based panel industry can be effectively solved. In this study, in general, thermoplastic-bonded wood-based panels presented relatively higher mechanical properties and better water resistance and machinability than the conventional urea–formaldehyde resin-bonded wood-based panels. However, the bonding structure of the wood and thermoplastic materials was unstable at high temperatures. Compared with the wood–plastic composites manufactured by the extruding or injection molding methods, thermoplastic-bonded wood-based panels have the advantages of larger size, a wider raw material range and higher production efficiency. The processing technology, bonding mechanism and the performance of thermoplastic-bonded wood-based panels are comprehensively summarized and reviewed in this paper. Meanwhile, the existing problems of this new kind of panel and their future development trends are also highlighted, which can provide the wood industry with foundations and guidelines for using thermoplastics as environmentally friendly adhesives and effectively solving indoor pollution problems

MANUFACTURING AND INTERFACIAL BONDING BEHAVIOR OF EVA FILM REINFORCED FLEXIBLE DECORATIVE VENEER

Polyethylene film reinforced flexible decorative veneer has attracted wide attention. However, its curling deformation has not been well solved due to the high processing temperature. Ethylene-vinyl acetate copolymer (EVA) has lower melting temperature and better flexibility than polyethylene. In this work, EVA film was selected to enhance Manchurian ash (Fraxinus mandshurica) aimed at preparing flexible decorative veneer with high strength and low curling degree. Box-Behnken experimental design method was applied to determine the optimum processing parameters. The secondary overlaying performance of the flexible veneer was evaluated. Under optimum conditions the EVA reinforced veneer obtained a maximum transverse tensile strength of 2.42 MPa. EVA can form a continuous interface with the veneer, which was helpful to improve the flexibility of the veneer. Curling degree of the EVA film reinforced veneer was far less than that of the polyethylene reinforced veneer even at the same processing temperature. EVA reinforced flexible veneer was good to be used to decorate wood-based panels without additional adhesives. Both immersion peel strength and surface bonding strength of the prepared decorative panel can meet the requirements of GB/T 15104-2006.