1 research outputs found
Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration
The regeneration of cartilage, an
aneural and avascular tissue,
is often compromised by its lack of innate abilities to mount a sufficient
healing response. Kartogenin (KGN), a small molecular compound, can
induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes.
The previous <i>in vitro</i> study showed that kartogenin
also had a chondrogenesis effect on synovium derived mesenchymal stem
cells (SMSCs). Herein, we present the effect of an ultraviolet-reactive,
rapidly cross-linkable scaffold integrated with kartogenin-loaded
nanoparticles using an innovational one-step technology. <i>In
vivo</i> studies showed its potential role for cell homing, especially
for recruiting the host’s endogenous cells, including BMSCs
and SMSCs, without cell transplantation. Of note, the regenerated
tissues were close to the natural hyaline cartilage based on the histological
tests, specific markers analysis, and biomechanical tests. This innovative
KGN release system makes the chondrogenesis efficient and persistent