Comparisons of equivalent and detailed models of metallic honeycomb core structures with in-plane thermal conductivities

AbstractEquivalent laminate model of the metallic honeycomb structure is given in the present paper firstly. The effective thermal model of the honeycomb core is anisotropic, and both in-plane and thickness direction effective thermal conductivity are deduced using the Swann-Pittman model. The effective mechanical properties of the honeycomb core are determined using the mechanics of materials method, and the effective continuum properties are then used with classical laminate theory to construct an equivalent laminate plate to simulate the response of three-dimensional honeycomb core structure. Then the thermal and free vibration behaviors of the equivalent laminate plate are compared with that of detailed model of the honeycomb core plate using finite element method. Numerical results show that the equivalent model is in good agreement with the detailed model in heat transfer and modal analysis

How physicians respond to negative emotions in high-risk preoperative conversations

This work was supported by the China Medical Board, CMB 14-200.Objective To investigate physicians’ responses to negative emotions in high-risk preoperative conversations; and to explore the influencing factors of these responses. Methods One hundred and sixty-two audio recordings were coded using the Chinese Verona Coding Definition of Emotional Sequences (VR-CoDES). Big Five Personality Inventory Brief Version and Emotional Intelligence Scale were administered to explore the influencing factors of physicians’ responses. SPSS 24.0 and R 3.6.3 LME4 Package were used for data analysis. Results Reduce Space (83%), referring to physicians’ responses reducing the opportunities of patients to disclose emotions, was physicians’ most frequent response to patients or families’ emotions. The main responses were Information-advice (ERIa) and Ignoring (NRIa). Younger age, female, Agreeableness and Openness were factors positively associated with Explicit Provide Space (EP); Neuroticism was negatively correlated with EP. Extroversion was negatively correlated with Explicit Reduce Space (ER); Conscientiousness was negatively correlated with both EP and ER responses. Emotional intelligence had no significant influence on physicians’ responses. Conclusion The majority of physicians were inclined to reduce space by providing information advice or ignoring. Physicians’ responses were correlated with their gender, age and personality traits. Practice Implications The trainees’ gender, age and personality should be considered when conducting doctor-patient communication skills training.Publisher PDFPeer reviewe

Coding the negative emotions of family members and patients among the high-risk preoperative conversations with the Chinese version of VR-CoDES

Abstract Background Little is known about family members' and patients' expression of negative emotions among high‐risk preoperative conversations. Objectives This study aimed to identify the occurrence and patterns of the negative emotions of family members and patients in preoperative conversations, to investigate the conversation themes and to explore the correlation between the negative emotions and the conversation themes. Methods A retrospective study was conducted using the Chinese version of Verona Coding Definitions of Emotional Sequences (VR‐CoDES‐C) to code 297 conversations on high‐risk procedures. Inductive content analysis was used to analyse the topics in which negative emotions nested. The χ2 Test was used to test the association between the cues and the conversation themes. Results The occurrence rate of family members' and patients' negative emotions was very high (85.9%), much higher when compared to most conversations under other medical settings. The negative emotions were mainly expressed by cues (96.4%), and cue‐b (67.4%) was the most frequent category. Cues and concerns were mostly elicited by family members and patients (71.6%). Negative emotions were observed among seven themes, in which ‘Psychological stress relating to illness severity, family's care and financial burden’ (30.3%) ranked the top. Cue‐b, cue‐c and cue‐d had a significant correlation (p < .001) with certain themes. Conclusions Family members and patients conveyed significantly more negative emotions in the high‐risk preoperative conversations than in other medical communications. Certain categories of cues were induced by specific emotional conversation contents. Patient Contribution Family members and patients contributed to data

Nrdp1 Increases Ischemia Induced Primary Rat Cerebral Cortical Neurons and Pheochromocytoma Cells Apoptosis Via Downregulation of HIF-1α Protein

Neuregulin receptor degradation protein-1 (Nrdp1) is an E3 ubiquitin ligase that targets proteins for degradation and regulates cell growth, apoptosis and oxidative stress in various cell types. We have previously shown that Nrdp1 is implicated in ischemic cardiomyocyte death. In this study, we investigated the change of Nrdp1 expression in ischemic neurons and its role in ischemic neuronal injury. Primary rat cerebral cortical neurons and pheochromocytoma (PC12) cells were infected with adenoviral constructs expressing Nrdp1 gene or its siRNA before exposing to oxygen-glucose deprivation (OGD) treatment. Our data showed that Nrdp1 was upregulated in ischemic brain tissue 3 h after middle cerebral artery occlusion (MCAO) and in OGD-treated neurons. Of note, Nrdp1 overexpression by Ad-Nrdp1 enhanced OGD-induced neuron apoptosis, while knockdown of Nrdp1 with siRNA attenuated this effect, implicating a role of Nrdp1 in ischemic neuron injury. Moreover, Nrdp1 upregulation is accompanied by increased protein ubiquitylation and decreased protein levels of ubiquitin-specific protease 8 (USP8) in OGD-treated neurons, which led to a suppressed interaction between USP8 and HIF-1α and subsequently a reduction in HIF-1α protein accumulation in neurons under OGD conditions. In conclusion, our data support an important role of Nrdp1 upregulation in ischemic neuronal death, and suppressing the interaction between USP8 and HIF-1α and consequently the hypoxic adaptive response of neurons may account for this detrimental effect

Motion of phase boundary during antiferroelectric–ferroelectric transition in a PbZrO3-based ceramic

The in situ biasing transmission electron microscopy technique is employed to investigate the nucleation and growth of the ferroelectric phase during the electric field-induced phase transition in Pb0.99{Nb0.02[(Zr0.57Sn0.43)0.94Ti0.06]0.98}O3, a PbZrO3-based antiferroelectric ceramic. The first-order displacive phase transition is found to be highly reversible with the initial antiferroelectric domain configuration almost completely recovered upon removal of the applied field. In the forward transition from the antiferroelectric to ferroelectric phase, {100}c facets are dominant on the phase boundary; while in the reverse transition from the ferroelectric to antiferroelectric phase during bias unloading, the phase boundary is segmented into {101}c and {121}c facets. The motion of the phase boundary is nonuniform, taking the form of sequential sweeping of facet segments. The elastic distortion energy and the depolarization energy at the antiferroelectric/ferroelectric phase boundary is suggested to dictate the facet motion