GRB 110709A, 111117A and 120107A: Faint high-energy gamma-ray photon emission from Fermi/LAT observations and demographic implications

Launched on June 11, 2008, the LAT instrument onboard the $Fermi$ Gamma-ray Space Telescope has provided a rare opportunity to study high energy photon emission from gamma-ray bursts. Although the majority of such events (27) have been iden tified by the Fermi LAT Collaboration, four were uncovered by using more sensiti ve statistical techniques (Akerlof et al 2010, Akerlof et al 2011, Zheng et al 2 012). In this paper, we continue our earlier work by finding three more GRBs ass ociated with high energy photon emission, GRB 110709A, 111117A and 120107A. To s ystematize our matched filter approach, a pipeline has been developed to identif y these objects in near real time. GRB 120107A is the first product of this anal ysis procedure. Despite the reduced threshold for identification, the number of GRB events has not increased significantly. This relative dearth of events with low photon number prompted a study of the apparent photon number distribution. W e find an extremely good fit to a simple power-law with an exponent of -1.8 $\pm$ 0.3 for the differential distribution. As might be expected, there is a substa ntial correlation between the number of lower energy photons detected by the GBM and the number observed by the LAT. Thus, high energy photon emission is associ ated with some but not all of the brighter GBM events. Deeper studies of the pro perties of the small population of high energy emitting bursts may eventually yi eld a better understanding of these entire phenomena.Comment: accepted to Ap

Effects of Contrarians in the Minority Game

We study the effects of the presence of contrarians in an agent-based model of competing populations. Contrarians are common in societies. These contrarians are agents who deliberately prefer to hold an opinion that is contrary to the prevailing idea of the commons or normal agents. Contrarians are introduced within the context of the Minority Game (MG), which is a binary model for an evolving and adaptive population of agents competing for a limited resource. Results of numerical simulations reveal that the average success rate among the agents depends non-monotonically on the fraction $a_{c}$ of contrarians. For small $a_{c}$, the contrarians systematically outperform the normal agents by avoiding the crowd effect and enhance the overall success rate. For high $a_{c}$, the anti-persistent nature of the MG is disturbed and the few normal agents outperform the contrarians. Qualitative discussion and analytic results for the small $a_{c}$ and high $a_{c}$ regimes are also presented, and the crossover behavior between the two regimes is discussed.Comment: revtex, 11 pages, 4 figure

Distances and classification of amino acids for different protein secondary structures

Window profiles of amino acids in protein sequences are taken as a description of the amino acid environment. The relative entropy or Kullback-Leibler distance derived from profiles is used as a measure of dissimilarity for comparison of amino acids and secondary structure conformations. Distance matrices of amino acid pairs at different conformations are obtained, which display a non-negligible dependence of amino acid similarity on conformations. Based on the conformation specific distances clustering analysis for amino acids is conducted.Comment: 15 pages, 8 figure

Molecular Mechanism of Z α1-Antitrypsin Deficiency.

The Z mutation (E342K) of α1-antitrypsin (α1-AT), carried by 4% of Northern Europeans, predisposes to early onset of emphysema due to decreased functional α1-AT in the lung and to liver cirrhosis due to accumulation of polymers in hepatocytes. However, it remains unclear why the Z mutation causes intracellular polymerization of nascent Z α1-AT and why 15% of the expressed Z α1-AT is secreted into circulation as functional, but polymerogenic, monomers. Here, we solve the crystal structure of the Z-monomer and have engineered replacements to assess the conformational role of residue Glu-342 in α1-AT. The results reveal that Z α1-AT has a labile strand 5 of the central β-sheet A (s5A) with a consequent equilibrium between a native inhibitory conformation, as in its crystal structure here, and an aberrant conformation with s5A only partially incorporated into the central β-sheet. This aberrant conformation, induced by the loss of interactions from the Glu-342 side chain, explains why Z α1-AT is prone to polymerization and readily binds to a 6-mer peptide, and it supports that annealing of s5A into the central β-sheet is a crucial step in the serpins' metastable conformational formation. The demonstration that the aberrant conformation can be rectified through stabilization of the labile s5A by binding of a small molecule opens a potential therapeutic approach for Z α1-AT deficiency

Autofocus for multispectral camera using focus symmetry

Author name used in this publication: Si-Jie ShaoAuthor name used in this publication: John H. Xin2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe