Chromium(III)-Catalyzed Desymmetrization of <i>meso</i>-Epoxides via Remote Stereocontrol: Synthesis of Chiral Fluorenes Bearing All-Carbon Quaternary Stereocenters

An asymmetric desymmetrization of fluorene-derived meso-epoxides is disclosed for the construction of chiral fluorenes bearing an all-carbon quaternary stereocenter at C9. This desymmetrization is catalyzed by a chiral (salen)CrIII complex via remote stereocontrol, producing diverse chiral fluorenes with excellent yields and stereoselectivity. The practicality of this protocol was demonstrated through the transformation of the obtained products to some intriguing enantioenriched polymerizable monomers

Mo- and Fe-Modified Ni(OH)₂/NiOOH Nanosheets as Highly Active and Stable Electrocatalysts for Oxygen Evolution Reaction

Highly active and stable electrocatalysts for oxygen evolution reaction (OER) are required for industrial hydrogen production. Herein, we report Mo and Fe modification as a synergistic effect to enhance both activity and stability for OER. The Mo- and Fe-modified Ni­(OH)₂/NiOOH nanosheets needs an overpotential of only ∼280 mV to achieve a current density of 100 mA cm^–2 and shows no evidence of degradation after 50 h at such high current density, outperforming all OER catalysts reported to date. This work may provide options for the design and preparation of promising OER electrocatalysts

Study characteristics of the meta-analysis for cancer risk.

<p>Study characteristics of the meta-analysis for cancer risk.</p

Association of mTOR Polymorphisms with Cancer Risk and Clinical Outcomes: A Meta-Analysis

<div><p>Genetic polymorphisms in mTOR gene may be associated with cancer risk and clinical outcomes of cancer patients by affecting mTOR gene expression or its activation. However, inconsistent results have been reported. The aim of this study is to systematically evaluate the association between mTOR polymorphisms (rs2295080, rs2536 and rs11121704) and cancer risk as well as clinical outcome by a meta-analysis. We identified 10 eligible studies and extracted data by two investigators. Based on dominant and recessive models, odds ratio (ORs) and 95% confidence intervals (CIs) were calculated by using Stata, version 11 to evaluate the association strength. Our meta-analysis results showed that the wild genotype TT of rs2295080 polymorphism was associated with increased cancer risk under dominant model (OR = 1.24, 95%CI: 1.12–1.36, p<0.0005) in Chinese but not with clinical outcome parameters, while the TT genotype of rs11121704 was associated with poor clinical outcome parameters (OR = 1.53, 95%CI: 1.01–2.32, p = 0.044), such as death, metastasis and resistance to chemotherapy. However, rs2536 may not influence cancer susceptibility. In conclusion, this meta-analysis indicated the common polymorphisms in <i>mTOR</i> gene might be genetic risk factors for the carcinogenesis and clinical outcomes of cancer patients. However, further investigation on large population and different ethnicities are warranted.</p></div

Forest plots of clinical outcomes with the mTOR rs2529080 and rs11121704 polymorphisms under the recessive model.

<p>Forest plots of clinical outcomes with the mTOR rs2529080 and rs11121704 polymorphisms under the recessive model.</p

Forest plots of cancer risk with rs2529080 and rs2536 polymorphisms under the dominant and recessive models.

<p>Forest plots of cancer risk with rs2529080 and rs2536 polymorphisms under the dominant and recessive models.</p

Study characteristics of the meta-analysis for clinical outcomes.

<p>NSCLC, Non-small-cell lung carcinoma.</p

Flow of study identification, inclusion, exclusion.

<p>Flow of study identification, inclusion, exclusion.</p

Funnel plots to detect publication bias.

<p>Each point represents an independent study for the indicated association.</p

Evidence for the Loss of GRIM-19 or NDUFS3 in Relation to Metastatic Potential from Different Mammary Cell Lines.

<p>Elevated protein levels of FN, Integrins, N-cadherin and HIF1α were observed in highly metastatic breast cancer cell lines while decreased protein level of GRIM-19 and NDUFS3 is observed in these cell lines. The lysates from 10 different breast cancer cell lines were subjected to Western blot using indicated primary antibodies and GAPDH as a loading control.</p