856 research outputs found

    Diffusion360: Seamless 360 Degree Panoramic Image Generation based on Diffusion Models

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    This is a technical report on the 360-degree panoramic image generation task based on diffusion models. Unlike ordinary 2D images, 360-degree panoramic images capture the entire 360×180360^\circ\times 180^\circ field of view. So the rightmost and the leftmost sides of the 360 panoramic image should be continued, which is the main challenge in this field. However, the current diffusion pipeline is not appropriate for generating such a seamless 360-degree panoramic image. To this end, we propose a circular blending strategy on both the denoising and VAE decoding stages to maintain the geometry continuity. Based on this, we present two models for \textbf{Text-to-360-panoramas} and \textbf{Single-Image-to-360-panoramas} tasks. The code has been released as an open-source project at \href{https://github.com/ArcherFMY/SD-T2I-360PanoImage}{https://github.com/ArcherFMY/SD-T2I-360PanoImage} and \href{https://www.modelscope.cn/models/damo/cv_diffusion_text-to-360panorama-image_generation/summary}{ModelScope}Comment: 2 pages, 8 figures, Tech. Repor

    Research on Decomposition of Urban Energy-Saving Indicator Based on Combination Weighting and Clustering

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    [Introduction] The proposal of the "dual carbon" strategy has given new requirements and connotations to the reduction of energy consumption intensity and the "dual control" of the total amount. On the premise of adhering to the priority of energy efficiency, we should fully consider the stage of regional development and reasonably ensure the "dual control" indicators are decomposed and implemented layer by layer. [Method] Taking the decomposition of the "dual control" indicators of energy consumption in the "14th Five-Year Plan" of a certain city as an example, this paper selected quantifications that could reflect the economic level, energy consumption volume, energy-saving potential and the completion of the energy-saving goals of the "13th Five-Year Plan" indicators of each district and county (city) and built a combined weighting assignment model based on the combination of hierarchical analysis and objective weighting to calculate the weight of each indicator, obtaining the "dual control" indicator distribution results, and then used clustering analysis to carry out the differentiation of the indicator system and cluster aggregation. [Result] By comparing the results of combination weighting and clustering analysis, the regional energy consumption intensity reduction target decomposition algorithm based on multi-indicator combination weighting and clustering analysis can obtain basically consistent results. [Conclusion] Based on the results of the above two methods, the actual economic development and government management needs, the energy consumption management targets of different levels are obtained, which takes into account regional development differences, conforms to the national "14th Five-Year Plan" energy consumption "dual control" system requirements and decomposition principle, and has the characteristics of replicability and promotion

    Effectiveness of atosiban in women with previous single implantation failure undergoing frozen-thawed blastocyst transfer : study protocol for a randomised controlled trial

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    © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Peer reviewedPublisher PD

    Transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis B virus replication

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    Hepatitis B Virus (HBV) replication in hepatocytes is restricted by the host innate immune system and related intracellular signaling pathways. Transforming growth factor β-activated kinase 1 (TAK1) is a key mediator of toll-like receptors and pro-inflammatory cytokine signaling pathways. Here, we report that silencing or inhibition of endogenous TAK1 in hepatoma cell lines leads to an upregulation of HBV replication, transcription, and antigen expression. In contrast, overexpression of TAK1 significantly suppresses HBV replication, while an enzymatically inactive form of TAK1 exerts no effect. By screening TAK1-associated signaling pathways with inhibitors and siRNAs, we found that the MAPK-JNK pathway was involved in TAK1-mediated HBV suppression. Moreover, TAK1 knockdown or JNK pathway inhibition induced the expression of farnesoid X receptor α, a transcription factor that upregulates HBV transcription. Finally, ectopic expression of TAK1 in a HBV hydrodynamic injection mouse model resulted in lower levels of HBV DNA and antigens in both liver and serum. In conclusion, our data suggest that TAK1 inhibits HBV primarily at viral transcription level through activation of MAPK-JNK pathway, thus TAK1 represents an intrinsic host restriction factor for HBV replication in hepatocytes

    Comparison of endometrial preparation protocols (natural cycle versus hormone replacement cycle) for frozen embryo transfer (COMPETE) : A study protocol for a randomised controlled trial

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    Funding Information: This study is supported by General Projects of Social Development (2022SF-565). BWM is supported by a NHMRC Investigator grant (GNT1176437). BWM reports consultancy for ObsEva. BMW has received research funding from Ferring and Merck. The other authors have none to declare. Acknowledgements: We thank all the physicians, scientists, and embryologists in our IVF clinic for their assistance with data collection as well the patients for participating in this studyPeer reviewedPublisher PD
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