A digital audio equalizer with Optimal Error Feedback Structure

A digital audio equalizer (EQ) with optimal Error Feedback (EF) structure is presented and implemented based on FPGA in this paper. The signal processed by this EQ is 24bits digital audio signal of PCM format, and the coefficients are of 27 bits length. As the feedback coefficients are adjusted with the poles of the Optimal Error Feedback Structures, the distinguishing advantage of this proposed equalizer is that it can completely eliminate the truncation noise caused by the poles when comparing with current technology. ? 2010 IEEE.EI

Role of Matrix Metallopeptidase 12 in the Development of Hepatocellular Carcinoma

Objective The aim of this study was to investigate the role of matrix metallopeptidase 12 (MMP-12) in the development of hepatocellular carcinoma (HCC). Materials and Methods: A total of 343 HCC patients were retrospectively analyzed. MMP-12 expression was detected by immunohistochemical staining and the correlation between MMP-12 expression and clinical features was analyzed. Serum interleukin-6 (IL-6) and IL-10 levels were detected by an enzyme-linked immunosorbent assay (ELISA). Survival analysis was performed using the Kaplan–Meier method and PD-L1 expression in T cells was detected by flow cytometry. Results: MMP-12 expression in HCC tissues showed no correlation with age, gender, viral infection, cirrhosis, Child-Pugh score, alpha-fetoprotein levels, or Barcelona-Clinic Liver Cancer stage. However, higher levels of MMP-12 expression were correlated with increased tumor size, poorer tumor cell differentiation, higher TNM stage, and poorer prognosis. Moreover, MMP-12 expression was positively correlated with PD-L1 expression. Further analysis indicated that the regulation of PD-L1 expression by MMP-12 may occur through the IL-6-signaling pathway. Conclusions: Higher levels of MMP-12 expression indicated a poorer prognosis. PD-L1 expression was positively correlated with MMP-12 expression, indicating that MMP-12 may promote the development of HCC through the up-regulation of PD-L1

Additional file 1 of Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells

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