The associations between serum 25(OH)D concentrations and triglycerides, total cholesterol.

(a, c) Each black point represents a sample and the red line represents the general trend of these samples. (b, d) Associations of serum 25(OH)D concentrations with triglycerides, total cholesterol stratified by occupations. Sex, age, each particular race, BMI, smoking, heavy alcohol, diabetes, hypertension, vigorous physical activity, education level, and marital status were adjusted.</p

Baseline characteristics of 3937 participants according to occupation.

Baseline characteristics of 3937 participants according to occupation.</p

The associations between serum 25(OH)D concentrations and LDL cholesterol, LDL cholesterol, HDL-C/LDL-C.

(a, c, e) Each black point represents a sample and the red line represents the general trend of these samples. (b, d, f) Associations of serum 25(OH)D concentrations with LDL cholesterol, HDL cholesterol and HDL-C/LDL/C stratified by occupations. Sex, age, each particular race, BMI, smoking, heavy alcohol, diabetes, hypertension, vigorous physical activity, education level, and marital status were adjusted.</p

Threshold effect analysis of serum 25(OH)D concentrations on lipid profiles.

Threshold effect analysis of serum 25(OH)D concentrations on lipid profiles.</p

The associations of serum 25(OH)D concentrations with lipid profiles in three occupations.

The associations of serum 25(OH)D concentrations with lipid profiles in three occupations.</p

The stratified analyses of the associations of serum 25(OH)D concentrations with lipid profiles in AFF occupations (with fully adjusted model).

The stratified analyses of the associations of serum 25(OH)D concentrations with lipid profiles in AFF occupations (with fully adjusted model).</p

Flow chat of sample selection from the NHANES 2001–2014.

Flow chat of sample selection from the NHANES 2001–2014.</p

The unique association between serum 25-hydroxyvitamin D concentrations and blood lipid profiles in agriculture, forestry, and fishing occupations insights from NHANES 2001-2014:Dataset

The study concludes that serum 25(OH)D levels are associated with lipid profiles and that this relationship varies among different occupational groups. Specifically, AFF workers may benefit from maintaining adequate serum 25(OH)D levels to mitigate adverse lipid profiles and reduce cardiovascular risk. This research provides insights into the unique occupational challenges faced by individuals in AFF occupations and the potential impact on their health, particularly in relation to vitamin D and lipid metabolism.</p

Contains S1-S4 Tables and S1-S3 Figs.

BackgroundThe relationship of serum 25(OH)D levels and hyperlipidemia has not been explored in the Agriculture, Forestry, and Fishing (AFF) occupation. We aimed to explore the impact of serum 25(OH)D levels on lipid profiles in AFF workers, traffic drivers, and miners.MethodsData from 3937 adults aged 18–65 years old with completed information were obtained from the National Health and Examination Survey from 2001 to 2014. Multivariate linear regression models were used to examine the associations between serum 25(OH)D concentrations and triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and HDL-C/LDL-C ratio. Subgroup analyses for AFF workers considered age, sex, BMI, work activity, months worked, and alcohol consumption. Non-linear relationships were explored using curve fitting.ResultsSerum 25(OH)D levels differed between groups (AFF: 60.0 ± 21.3 nmol/L, drivers: 56.6 ± 22.2 nmol/L, miners: 62.8 ± 22.3 nmol/L). Subgroup analysis of the AFF group showed that participants with serum 25(OH)D ≥50 nmol/L, females, and BMI 2 demonstrated improved HDL-C levels correlating with higher serum 25(OH)D. Serum 25(OH)D in AFF workers had a reversed U-shaped relationship with TG and TC, and a U-shaped relationship with HDL-C, with HDL-C, with inflection points at 49.5 nmol/L for TG and TC, and 32.6 nmol/L for HDL-C.ConclusionsSerum 25(OH)D levels are associated with lipid profiles, and the relationship varies among occupational groups. AFF workers, facing unique occupational challenges, may benefit from maintaining adequate serum 25(OH)D levels to mitigate adverse lipid profiles and reduce cardiovascular risk.</div