SEM images (×5000) of nanofibers fabricated by spinning solutions containing A1 6% PVA.

<p>A2 8% PVA. A3 10% PVA. B1 4% HPβCD, 8% PVA. B2 6% HPβCD, 8% PVA. B3 8% HPβCD, 8% PVA. C1 0.5% VRC, 4% HPβCD, 8% PVA (F1). C2 0.7% VRC, 6% HPβCD, 8% PVA (F2). C3 0.8% VRC, 8% HPβCD, 8% PVA (F3).</p

¹H-NMR spectra of VRC, PVA/HPβCD nanofibers and VRC nanofibers.

<p>The insert was the integration of VRC peak (1.11ppm) and HPβCD peak (1.03 ppm).</p

Results of irritation test at day 7 after the administration of VRC nanofibers or VRC solution.

<p>A-C Images of rabbit eyes. D-F Optical micrographs of corneal tissue (A, D Control. B, E VRC solution. C, F VRC nanofibers).</p

Concentration-time curves of VRC in tears after topical application of VRC solution or VRC-loaded nanofibers to the rabbit eye (n = 4, ±<i>SD</i>).

<p>Concentration-time curves of VRC in tears after topical application of VRC solution or VRC-loaded nanofibers to the rabbit eye (n = 4, ±<i>SD</i>).</p

Solubility diagram for VRC in HPβCD at 37°C.

<p>Solubility diagram for VRC in HPβCD at 37°C.</p

TGA thermograms of VRC, HPβCD, PVA, PVA/HPβCD nanofibers and VRC nanofibers.

<p>TGA thermograms of VRC, HPβCD, PVA, PVA/HPβCD nanofibers and VRC nanofibers.</p

DSC thermograms of HPβCD, PVA, VRC, PVA/HPβCD nanofibers and VRC nanofibers.

<p>DSC thermograms of HPβCD, PVA, VRC, PVA/HPβCD nanofibers and VRC nanofibers.</p

<i>In vitro</i> release of VRC electrospun nanofibers.

<p><i>In vitro</i> release of VRC electrospun nanofibers.</p

Pharmacokinetic parameters of VRC in rabbit tears (±<i>SD</i>, n = 4).

<p>Pharmacokinetic parameters of VRC in rabbit tears (±<i>SD</i>, n = 4).</p

FT-IR spectra of VRC, PVA, HPβCD, PVA/HPβCD nanofibers and VRC electrospun nanofibers.

<p>FT-IR spectra of VRC, PVA, HPβCD, PVA/HPβCD nanofibers and VRC electrospun nanofibers.</p