Securing water for wetland conservation: A comparative analysis of policy options to protect a national nature reserve in China

This study evaluates four policy options to secure the water supply needed for wetland conservation in Qixinghe—a national wetland nature reserve in China—using four criteria: cost effectiveness, probability of success in achieving the water-saving goal, political feasibility, and farmer acceptance. This multi-criteria analysis framework reveals the ecological, economic, and socio-political trade-offs for policymakers when choosing among the four policy options. Results suggest that upgrading irrigation infrastructure in the area surrounding the wetland (Option I) is the most politically feasible option, but it is the second best option in terms of cost effectiveness. Constructing a dam to store and control floodwater (Option II) is the most reliable for achieving the water-saving goal. It is also the farmers’ most favored strategy. But this option is the least cost effective and receives little support from local governments. Promoting farmers’ adoption of water-saving practices (Option III) is the most cost effective, but it is less reliable for achieving the water-saving goal than Options I or II. Converting paddy crops to dry-land crops (Option IV) is politically infeasible and least reliable for achieving the water-saving goal. The overall ranking of the four options is determined using the policymakers’ revealed weights on the four criteria. Option I is ranked first, followed by Options II, III, and IV.Keywords: Cost effectiveness, Multi-criteria decision making, Water resource management, Agricultural water use, Wetland conservatio

Toxicity study of oral vanadyl sulfate by NMR-based metabonomic

Vanadium compounds have been believed to be ideal drugs for diabetes biological therapy in future, but they suffer setback for the potential toxicity now. Toxicity study is necessary for vanadyl drugs development. This paper investigated the toxicity effects of vanadyl sulfate (VOSO4) oral administration in male Wistar rats using H-1 NMR-based metabonomic analysis and clinical biochemical analysis. Rat urine were collected and their H-1 NMR spectra were acquired, and then subjected to multi-variable statistical analysis. Compared to control groups, urinary excretion of lactate, TMAO, creatinine, taurine and hippurate increased following VOSO4 dosing, with concomitant decrease in the level of acetate and succinate. The dosed groups can be readily discriminated from the control groups by principle component analysis. The results showed that VOSO4 can affect energy metabolism process, interrupted intestinal microfloral metabolism, and induced liver and kidney injury. NMR-based metabonomic can offer additional information to traditional clinical chemistry in the sensitivity and specificity of results obtained

Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis

ObjectivePrimary nocturnal enuresis (PNE) is a common developmental condition in school-aged children. The objective is to better understand the pathophysiology of PNE by using insula-centered resting-state functional connectivity (rsFC).MethodsWe recruited 66 right-handed participants in our analysis, 33 with PNE and 33 healthy control (HC) children without enuresis matched for gender and age. Functional and structural MRI data were obtained from all the children. Seed-based rsFC was used to examine differences in insular functional connectivity between the PNE and HC groups. Correlation analyses were carried out to explore the relationship between abnormal insula-centered functional connectivity and clinical characteristics in the PNE group.ResultsCompared with HC children, the children with PNE demonstrated decreased left and right insular rsFC with the right medial superior frontal gyrus (SFG). In addition, the bilateral dorsal anterior insula (dAI) seeds also indicated the reduced rsFC with right medial SFG. Furthermore, the right posterior insula (PI) seed showed the weaker rsFC with the right medial SFG, while the left PI seed displayed the weaker rsFC with the right SFG. No statistically significant correlations were detected between aberrant insular rsFC and clinical variables (e.g., micturition desire awakening, bed-wetting frequency, and bladder volume) in results without global signal regression (GSR) in the PNE group. However, before and after setting age as a covariate, significant and positive correlations between bladder volume and the rsFC of the left dAI with right medial SFG and the rsFC of the right PI with right medial SFG were found in results with GSR in the PNE group.ConclusionTo the best of our knowledge, this study explored the rsFC patterns of the insula in children with PNE for the first time. These results uncovered the abnormal rsFC of the insula with the medial prefrontal cortex without and with GSR in the PNE group, suggesting that dysconnectivity of the salience network (SN)-default mode network (DMN) may involve in the underlying pathophysiology of children with PNE. However, the inconsistent associations between bladder volume and dysconnectivity of the SN-DMN in results without and with GSR need further studies