Bilateral-Fuser: A Novel Multi-cue Fusion Architecture with Anatomical-aware Tokens for Fovea Localization

Accurate localization of fovea is one of the primary steps in analyzing retinal diseases since it helps prevent irreversible vision loss. Although current deep learning-based methods achieve better performance than traditional methods, there still remain challenges such as utilizing anatomical landmarks insufficiently, sensitivity to diseased retinal images and various image conditions. In this paper, we propose a novel transformer-based architecture (Bilateral-Fuser) for multi-cue fusion. This architecture explicitly incorporates long-range connections and global features using retina and vessel distributions for robust fovea localization. We introduce a spatial attention mechanism in the dual-stream encoder for extracting and fusing self-learned anatomical information. This design focuses more on features distributed along blood vessels and significantly decreases computational costs by reducing token numbers. Our comprehensive experiments show that the proposed architecture achieves state-of-the-art performance on two public and one large-scale private datasets. We also present that the Bilateral-Fuser is more robust on both normal and diseased retina images and has better generalization capacity in cross-dataset experiments.Comment: This paper is prepared for IEEE TRANSACTIONS ON MEDICAL IMAGIN

New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway

Due to the complex etiology of rheumatoid arthritis (RA), it is difficult to be completely cured at the current stage although many approaches have been applied in clinics, especially the wide application of nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs). New drug discovery and development via the recently discovered cholinergic anti-inflammatory and antinociceptive pathways should be promising. Based on the above, the nicotinic acetylcholine receptor agonists maintain the potential for the treatment of RA. Therefore, new therapeutic approaches may rise from these two newly discovered pathways. More preclinical experiments and clinical trials are required to confirm our viewpoint

Stellar Parameters of Main Sequence Turn-off Star Candidates Observed with the LAMOST and Kepler

Main sequence turn-off (MSTO) stars have advantages as indicators of Galactic evolution since their ages could be robustly estimated from atmospheric parameters. Hundreds of thousands of MSTO stars have been selected from the LAMOST Galactic sur- vey to study the evolution of the Galaxy, and it is vital to derive accurate stellar parameters. In this work, we select 150 MSTO star candidates from the MSTO stars sample of Xiang that have asteroseismic parameters and determine accurate stellar parameters for these stars combing the asteroseismic parameters deduced from the Kepler photometry and atmospheric parameters deduced from the LAMOST spectra.With this sample, we examine the age deter- mination as well as the contamination rate of the MSTO stars sample. A comparison of age between this work and Xiang shows a mean difference of 0.53 Gyr (7%) and a dispersion of 2.71 Gyr (28%). The results show that 79 of the candidates are MSTO stars, while the others are contaminations from either main sequence or sub-giant stars. The contamination rate for the oldest stars is much higher than that for the younger stars. The main cause for the high contamination rate is found to be the relatively large systematic bias in the LAMOST surface gravity estimates.Comment: accepted by RA

Hydrogels enable negative pressure in water for efficient heat utilization and transfer

Metastable water in negative pressure can provide giant passive driving pressure up to several megapascals for efficient evaporation-driven flow, however, the practical applications with negative pressure are rare due to the challenges of generating and maintaining large negative pressure. In this work, we report a novel structure with thin hydrogel films as evaporation surfaces and robust porous substrates as the supports, and obtain a high negative pressure of -1.61 MPa through water evaporation. Molecular dynamics simulations elucidate the essential role of strong interaction between water molecules and polymer chains in generating the negative pressure. With such a large negative pressure, we demonstrate a streaming potential generator that spontaneously converts environmental energy into electricity and outputs a voltage of 1.06 V. Moreover, we propose a "negative pressure heat pipe" for the first time, which achieves a high heat transfer density of 11.2 kW cm-2 with a flow length of 1 m, showing the potential of negative pressure in efficient heat utilization and transfer.Comment: 43 pages, 18 figure

Exploiting Spatial-temporal Data for Sleep Stage Classification via Hypergraph Learning

Sleep stage classification is crucial for detecting patients' health conditions. Existing models, which mainly use Convolutional Neural Networks (CNN) for modelling Euclidean data and Graph Convolution Networks (GNN) for modelling non-Euclidean data, are unable to consider the heterogeneity and interactivity of multimodal data as well as the spatial-temporal correlation simultaneously, which hinders a further improvement of classification performance. In this paper, we propose a dynamic learning framework STHL, which introduces hypergraph to encode spatial-temporal data for sleep stage classification. Hypergraphs can construct multi-modal/multi-type data instead of using simple pairwise between two subjects. STHL creates spatial and temporal hyperedges separately to build node correlations, then it conducts type-specific hypergraph learning process to encode the attributes into the embedding space. Extensive experiments show that our proposed STHL outperforms the state-of-the-art models in sleep stage classification tasks

Bilateral-ViT For Robust Fovea Localization

The fovea is an important anatomical landmark of the retina. Detecting the location of the fovea is essential for the analysis of many retinal diseases. However, robust fovea localization remains a challenging problem, as the fovea region often appears fuzzy, and retina diseases may further obscure its appearance. This paper proposes a novel Vision Transformer (ViT) approach that integrates information both inside and outside the fovea region to achieve robust fovea localization. Our proposed network, named Bilateral-Vision-Transformer (Bilateral-ViT), consists of two network branches: a transformer-based main network branch for integrating global context across the entire fundus image and a vessel branch for explicitly incorporating the structure of blood vessels. The encoded features from both network branches are subsequently merged with a customized Multi-scale Feature Fusion (MFF) module. Our comprehensive experiments demonstrate that the proposed approach is significantly more robust for diseased images and establishes the new state of the arts using the Messidor and PALM datasets.Comment: This work has been accepted for oral presentation by ISBI202

Observation of Fungi, Bacteria, and Parasites in Clinical Skin Samples Using Scanning Electron Microscopy

This chapter highlights the description of the clinical manifestation and its pathogen and the host tissue damage observed under the Scanning Electron Microscope, which helps the clinician to understand the pathogen’s superstructure, the change of host subcell structure, and the laboratory workers to understand the clinical characteristics of pathogen-induced human skin lesions, to establish a two-way learning exchange database with vivid image