2-(4-Chloro­phen­oxy)-N′-[2-(4-chloro­phen­oxy)acet­yl]acetohydrazide monohydrate

In the title compound, C16H14Cl2N2O4·H2O, the hydrazine and water mol­ecules are both located on twofold axes. The C—N—N—C torsion angle is −72.66 (1)° and the dihedral angle between the two benzene rings is 67.33 (1)°. In the crystal, mol­ecules are linked into a layer structure by a combination of O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds. Adjacent layers are linked into a three-dimensional network by Cl⋯Cl inter­actions [3.400 (2) Å]. C—H⋯π inter­actions are also observed

(Dimeth­oxy­phosphor­yl)(furan-2-yl)methyl 2-(2,4-dichloro­phen­oxy)acetate

In the title compound, C15H15Cl2O7P, the benzene and furan rings form a dihedral angle of 73.54 (1)°. In the crystal, weak inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into layers parallel to (100)

Growth of Large Domain Epitaxial Graphene on the C-Face of SiC

Growth of epitaxial graphene on the C-face of SiC has been investigated. Using a confinement controlled sublimation (CCS) method, we have achieved well controlled growth and been able to observe propagation of uniform monolayer graphene. Surface patterns uncover two important aspects of the growth, i.e. carbon diffusion and stoichiometric requirement. Moreover, a new "stepdown" growth mode has been discovered. Via this mode, monolayer graphene domains can have an area of hundreds of square micrometers, while, most importantly, step bunching is avoided and the initial uniformly stepped SiC surface is preserved. The stepdown growth provides a possible route towards uniform epitaxial graphene in wafer size without compromising the initial flat surface morphology of SiC.Comment: 18 pages, 8 figure

Synthesis of Porous NiO and ZnO Submicro- and Nanofibers from Electrospun Polymer Fiber Templates

Porous nickel oxide (NiO) and zinc oxide (ZnO) submicro- and nanofibers were synthesized by impregnating electrospun polyacrylonitrile (PAN) fiber templates with corresponding metal nitrate aqueous solutions and subsequent calcination. The diameter of the NiO and ZnO fibers was closely related to that of the template fibers and larger diameters were obtained when using the template fibers with larger diameter. SEM results showed that the NiO and ZnO fibers have a large amount of pores with diameters ranging from 5 nm to 20 nm and 50 nm to 100 nm, respectively. Energy dispersive X-ray (EDX) spectra and X-ray diffraction (XRD) patterns testified that the obtained materials were NiO and ZnO with high purity

Human-like Energy Management Based on Deep Reinforcement Learning and Historical Driving Experiences

Development of hybrid electric vehicles depends on an advanced and efficient energy management strategy (EMS). With online and real-time requirements in mind, this article presents a human-like energy management framework for hybrid electric vehicles according to deep reinforcement learning methods and collected historical driving data. The hybrid powertrain studied has a series-parallel topology, and its control-oriented modeling is founded first. Then, the distinctive deep reinforcement learning (DRL) algorithm, named deep deterministic policy gradient (DDPG), is introduced. To enhance the derived power split controls in the DRL framework, the global optimal control trajectories obtained from dynamic programming (DP) are regarded as expert knowledge to train the DDPG model. This operation guarantees the optimality of the proposed control architecture. Moreover, the collected historical driving data based on experienced drivers are employed to replace the DP-based controls, and thus construct the human-like EMSs. Finally, different categories of experiments are executed to estimate the optimality and adaptability of the proposed human-like EMS. Improvements in fuel economy and convergence rate indicate the effectiveness of the constructed control structure.Comment: 8 pages, 10 figure

(S)-2-[(2,4-Dichloro­phen­yl)(hy­droxy)meth­yl]-5,5-dimethyl-1,3,2-dioxa­phosphinane 2-oxide

In the title mol­ecule, C12H15Cl2O4P, the cyclic dioxaphosphinane ring adopts a chair conformation. In the crystal, inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into chains propagating along the b axis

Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation

To understand the molecular mechanisms that mediate the anti-hepatitis B virus (HBV) effect of interferon (IFN) therapy, we conduct highthroughput bimolecular fluorescence complementation screening to identify potential physical interactions between the HBx protein and 145 IFNstimulated genes (ISGs). Seven HBx-interacting ISGs have consistent and significant inhibitory effects on HBV replication, among which TRIM5g suppresses HBV replication by promoting K48-linked ubiquitination and degradation of the HBx protein on the K95 ubiquitin site. The B-Box domain of TRIM5g under overexpression conditions is sufficient to trigger HBx degradation and is responsible both for interacting with HBx and recruiting TRIM31, which is an ubiquitin ligase that triggers HBx ubiquitination. High expression levels of TRIM5g in IFN-a-treated HBV patients might indicate a better therapeutic effect. Thus, our studies identify a crucial role for TRIM5g and TRIM31 in promoting HBx degradation, which may facilitate the development of therapeutic agents for the treatment of patients with IFN-resistant HBV infection

Uncovering lupus nephritis-specific genes and the potential of TNFRSF17-targeted immunotherapy: a high-throughput sequencing study

IntroductionLupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE). This study aimed to identify LN specific-genes and potential therapeutic targets.MethodsWe performed high-throughput transcriptome sequencing on peripheral blood mononuclear cells (PBMCs) from LN patients. Healthy individuals and SLE patients without LN were used as controls. To validate the sequencing results, qRT-PCR was performed for 5 upregulated and 5 downregulated genes. Furthermore, the effect of the TNFRSF17-targeting drug IBI379 on patient plasma cells and B cells was evaluated by flow cytometry.ResultsOur analysis identified 1493 and 205 differential genes in the LN group compared to the control and SLE without LN groups respectively, with 70 genes common to both sets, marking them as LN-specific. These LN-specific genes were significantly enriched in the ‘regulation of biological quality’ GO term and the cell cycle pathway. Notably, several genes including TNFRSF17 were significantly overexpressed in the kidneys of both LN patients and NZB/W mice. TNFRSF17 levels correlated positively with urinary protein levels, and negatively with complement C3 and C4 levels in LN patients. The TNFRSF17-targeting drug IBI379 effectively induced apoptosis in patient plasma cells without significantly affecting B cells.DiscussionOur findings suggest that TNFRSF17 could serve as a potential therapeutic target for LN. Moreover, IBI379 is presented as a promising treatment option for LN