4 research outputs found
Visible-Light-Induced Radical Cascade Cyclization: Synthesis of the ABCD Ring Cores of Camptothecins
A new strategy for constructing indolizino[1,2-<i>b</i>]quinolin-9(11<i>H</i>)-ones (ring cores of camptothecins)
from readily available isocyanoarenes and <i>N</i>-(alkyl-2-yn-1-yl)pyridin-2(1<i>H</i>)-ones has been developed through a visible-light-induced
radical cascade cyclization process. The reaction proceeds under mild
conditions with fair to excellent yields. The easy introduction of
substituents for both reactants and the broad functional group tolerance
of the reaction make it a straightforward route to the cores of the
marketed camptothecins and their derivatives
Visible-Light-Induced Radical Cascade Cyclization: Synthesis of the ABCD Ring Cores of Camptothecins
A new strategy for constructing indolizino[1,2-<i>b</i>]quinolin-9(11<i>H</i>)-ones (ring cores of camptothecins)
from readily available isocyanoarenes and <i>N</i>-(alkyl-2-yn-1-yl)pyridin-2(1<i>H</i>)-ones has been developed through a visible-light-induced
radical cascade cyclization process. The reaction proceeds under mild
conditions with fair to excellent yields. The easy introduction of
substituents for both reactants and the broad functional group tolerance
of the reaction make it a straightforward route to the cores of the
marketed camptothecins and their derivatives
Visible-Light-Induced Photocatalytic Aerobic Oxidation/Povarov Cyclization Reaction: Synthesis of Substituted Quinoline-Fused Lactones
A one-step construction of quinoline-fused
lactones was achieved
by visible-light-induced photocatalytic aerobic oxidation/Povarov
cyclization reaction. This method provides a new access to the synthesis
of important fused heterocycles under mild reaction conditions
Combining Visible-Light-Photoredox and Lewis Acid Catalysis for the Synthesis of Indolizino[1,2‑<i>b</i>]quinolin-9(11<i>H</i>)‑ones and Irinotecan Precursor
One-step construction of substituted
indolizino[1,2-<i>b</i>]quinolin-9(11<i>H</i>)-ones
was achieved by combining
visible-light-photoredox and Lewis acid catalysis for an intramolecular
Povarov cycloaddition reaction under mild conditions. In this catalytic
process, the visible-light-promoted dehydrogenation protocol of tetrahydroquinolines
constitutes the key procedure. Moreover, this method can be applied
to the formal synthesis of the precursor of irinotecan, which exhibited
good anticancer activities