2 research outputs found
Gastric Protective Activities of Sea Cucumber Fucoidans with Different Molecular Weight and Chain Conformations: A Structure–Activity Relationship Investigation
A variety of bioactivities
has been established for fucoidan extracted
from sea cucumber, whereas its structure–activity relationships
have been seldom investigated. In this study, sea cucumber (<i>Thelenota ananas</i>) fucoidans with different molecular weights
were prepared with enzymatic degradation. The chain stiffness and
molecular size decreased with the decreasing of molecular weight.
Fucoidans with molecular weight of 1380.0, 828.7, and 483.0 kDa exhibited
random coil conformations, while fucoidan molecular weight of 215.0
kDa existed as sphere in solution. All examined fucoidans could effectively
prevent the ethanol-induced gastric ulcer, of which mechanism involved
antioxidation and anti-inflammation. Within the range of the study,
the performance of fucoidans adopted random coil conformations declined
with the decreasing of molecular weight, and the performance recovered
when the chain conformation transited from coil to sphere, indicating
the subtle influences of molecular weight and chain conformation on
the gastric protective activity of sea cucumber fucoidan
DataSheet_1_Implications for functional diversity conservation of China’s marine fisheries.docx
Functional diversity is critical to ecosystem stability and resilience to disturbances as it supports the delivery of ecosystem services on which human societies rely. However, changes in functional diversity over space and time, as well as the importance of particular marine fish species to functional space are less known. Here, we reported a temporal change in the functional diversity of marine capture fisheries from all coastal provinces in China from 1989 to 2018. We suggested that both functional evenness (FEve) and functional divergence (FDiv) changed substantially over time, especially with considerable geographic variation in FEve in the detected patterns. Even within the same sea, the relative contributions of fishes with various water column positions and trophic levels in different waters have different patterns. Together these results underline the need of implementing specific climate-adaptive functional diversity conservation measures and sustainable fisheries management in different waters.</p