Regioselective Formation of 2,4,5-Trisubstituted Oxazoles through Transition-Metal Free Heterocyclization of 1,3-Diynes with <i>N</i>,<i>O</i>‑Bis(trimethylsiyl)acetamide

Transition-metal free heterocyclization reaction of 1,3-diynes with <i>N</i>,<i>O</i>-bis­(trimethylsiyl)­acetamide was accomplished in the presence of <i>t</i>-BuOK and acetonitrile at 120 °C. This method regioselectively gave 2,4,5-trisubstituted oxazoles in yields up to 97%

Diasteroselective and Enantioselective Ir-Catalyzed Allylic Substitutions of 1‑Substituted 1‑Fluoro-1-(arenesulfonyl)methylene Derivatives

diasteroselective and enantioselective Ir-catalyzed allylic substitutions of 1-substituted 1-fluoro-1-(arenesulfonyl)­methylene derivatives are presented, which afford the fluorinated allyl products with two chirality centers. The steric demand of 1-substituted 1-fluoro-1-(arenesulfonyl)­methylene derivatives and allylic substrates has a great influence on the <i>dr</i> values of these reactions. The transformation of the branched allyl product into the fluorinated 3,4-dihydro-2<i>H</i>-pyrrole 1-oxide was discussed, as well

Diasteroselective and Enantioselective Ir-Catalyzed Allylic Substitutions of 1‑Substituted 1‑Fluoro-1-(arenesulfonyl)methylene Derivatives

diasteroselective and enantioselective Ir-catalyzed allylic substitutions of 1-substituted 1-fluoro-1-(arenesulfonyl)­methylene derivatives are presented, which afford the fluorinated allyl products with two chirality centers. The steric demand of 1-substituted 1-fluoro-1-(arenesulfonyl)­methylene derivatives and allylic substrates has a great influence on the <i>dr</i> values of these reactions. The transformation of the branched allyl product into the fluorinated 3,4-dihydro-2<i>H</i>-pyrrole 1-oxide was discussed, as well

Regioselective Fluorination of 1‑(2,2-Dibromovinyl)­benzene Derivatives with Wet Tetra‑<i>n</i>‑butyl­ammonium Fluoride: One-Pot Synthesis of (<i>Z</i>)‑1-(2-Bromo-1-fluorovinyl)­benzenes

A direct fluorination of 1-(2,2-dibromovinyl)­benzene derivatives using wet tetra-<i>n</i>-butylammonium fluoride (TBAF·3H₂O) as either a base or a fluorine source in toluene was accomplished, which provided (<i>Z</i>)-1-(2-bromo-1-fluorovinyl)­benzene compounds in up to 81% yields with high regioselectivities. This reaction results strongly depend upon the reaction conditions. The mechanism of this reaction was investigated as well

Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2‑Aminopyrimidines with Selectfluor

A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with Selectfluor in the presence of Ag­(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag­(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into <i>N</i>-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methyl­benzene­sulfonamide is discussed, and the reaction mechanism is investigated, as well

Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2‑Aminopyrimidines with Selectfluor

A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with Selectfluor in the presence of Ag­(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag­(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into <i>N</i>-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methyl­benzene­sulfonamide is discussed, and the reaction mechanism is investigated, as well

Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2‑Aminopyrimidines with Selectfluor

A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with Selectfluor in the presence of Ag­(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag­(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into <i>N</i>-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methyl­benzene­sulfonamide is discussed, and the reaction mechanism is investigated, as well

Selective Fluorination of 4‑Substituted 2‑Aminopyridines and Pyridin-2(1<i>H</i>)‑ones in Aqueous Solution

Fluorination of 2-aminopyridines and pyridin-2­(1<i>H</i>)-ones in the presence of Selectfluor, water, and chloroform under mild conditions has been realized. This method gives fluorinated pyridines in good to high yields with high regioselectivities. The electron-deficient pyridine system is activated by an amino or hydroxyl group at C2. The regioselectivity of the fluorination reaction is strongly dependent upon the substituent pattern in the 2-aminopyridine or pyridin-2­(1<i>H</i>)-one. The transformation of the 3-fluoro-substituted pyridine derivative into fluorinated zolimidine was achieved as well

The Association between Preoperative Serum C-Reactive Protein and Hepatocellular Carcinoma Recurrence in Patients with Chronic Hepatitis B Virus (HBV) Infection—A Retrospective Study

<div><p>The prognosis of the patients with hepatocellular carcinoma (HCC) recurrence following curative hepatectomy is usually dismal. Whether preoperative serum C-reactive protein (CRP) can predict the recurrence of HCC in patients with chronic HBV infection is not clear. Total 232 patients with chronic HBV infection were included in this retrospective study. We investigated the association between detailed preoperative serum CRP levels and early (≤ 2 year) and late (> 2 year) HCC recurrence following curative hepatectomy. After adjusting for potential confounders, we found a saturation effect for preoperative serum CRP of 2.1 mg/dl existed for early HCC recurrence (ER). The incidence of ER increased with preoperative serum CRP less than 2.1 mg/dl (OR = 3.5, 95% CI 1.6–7.6, P = 0.001), and higher preoperative serum CRP (>2.1 mg/dl) did not increase the incidence of ER (OR = 0.8, 95% CI 0.2–2.7, P = 0.703). Whereas there is a linear relationship between preoperative serum CRP and late HCC recurrence (LR) (OR = 0.2, 95% CI, 0.1- 0.4) (OR = 1.8, 95% CI, 1.2–2.5, P = 0.002). In addition, the optimal cutoff point for serum CRP level was 1.5 mg/dl, instead of 1.0 mg/dl, in predicting both ER and LR. Patients with higher preoperative serum CRP level (>1.5 mg/dl) had lower recurrence free survival rates and overall survival rates (P<0.01). These results suggest that preoperative serum CRP played different roles on ER and LR following curative hepatectomy, thus further predictingthe prognosis in patients with chronic HBV infection.</p></div

Additional file 1 of Identifying yield-related genes in maize based on ear trait plasticity

Additional file 1: Figure S1. Phenotypic variation of ears from transgenic inbred lines planted in 2018. Figure S2. Phenotypic variation of ears from transgenic inbred lines planted in 2019. Figure S3. Distribution of the coefficient of variation for transgenic inbred lines planted in 2018. Figure S4. Distribution of the coefficient of variation for transgenic inbred lines planted in 2019. Figure S5. Correlation matrix plot of phenotypic ear characteristics of transgenic inbred lines planted in 2019. Figure S6. Genetic correlations among mean phenotype values, linear plasticity, and nonlinear plasticity for transgenic inbred lines planted in 2018. Figure S7. Genetic correlations among mean phenotype values, linear plasticity, and nonlinear plasticity for transgenic inbred lines planted in 2019. Figure S8. Distribution of genetic values and linear plasticity of phenotypes for transgenic inbred lines planted in 2019. Figure S9. Phenotypic plasticity of transgenic lines planted in 2018. Figure S10. Phenotypic plasticity of transgenic lines planted in 2019. Figure S11. Analyzing the performance of 16 candidate regulatory genes screened in 2018 based on AMMI model, coefficient of variation (CV), and average phenotypic value. Figure S12. Analyzing the performance of 28 candidate regulatory screened in 2019 based on AMMI model, coefficient of variation (CV), and average phenotypic value. Figure S13. Flow chart of relationship between different layers of MAIZTRO. Figure S14. Effect of overexpression and knockout of GRMZM2G077278 on phenotypic plasticity for normal kernel number in 2018. Figure S15. Plot from FWR analysis of genes that performed well and were present in lines planted in both 2018 and 2019 (n = 10 genes). Figure S16. Plot from FWR analysis of genes that performed well and were present in lines planted only in 2018 (n = 6 genes). Figure S17. Plot from FWR analysis of genes that performed well and were present in lines planted only in 2019 (n = 18 genes)