Multi-Channel Magnetocardiogardiography System Based on Low-Tc SQUIDs in an Unshielded Environment

AbstractMagnetocardiography (MCG) using superconducting quantum interference devices (SQUIDs) is a new medical diagnostic tool measuring biomagnetic signals that are generated by the electrical activity of the human heart. This technique is completely passive, contactless, and it has an advantage in the early diagnosis of heart diseases. We developed the first unshielded four-channel MCG system based on low-Tc DC SQUIDs in China. Instead of using a costly magnetically shielded room, the environmental noise suppression was realized by using second-order gradiometers and three-axis reference magnetometer. The measured magnetic field resolution of the system is better than 1 pT, and multi-cycle human heart signals can be recorded directly. Also, with the infrared positioning system, 48 points data collection can be realized by moving the non-magnetic bed nine times

An improved adaptive triangular mesh-based image warping method

It is of vital importance to stitch the two images into a panorama in many computer vision applications of motion detection and tracking and virtual reality, panoramic photography, and virtual tours. To preserve more local details and with few artifacts in panoramas, this article presents an improved mesh-based joint optimization image stitching model. Since the uniform vertices are usually used in mesh-based warps, we consider the matched feature points and uniform points as grid vertices to strengthen constraints on deformed vertices. Simultaneously, we define an improved energy function and add a color similarity term to perform the alignment. In addition to good alignment and minimal local distortion, a regularization parameter strategy of combining our method with an as-projective-as-possible (APAP) warp is introduced. Then, controlling the proportion of each part by calculating the distance between the vertex and the nearest matched feature point to the vertex. This ensures a more natural stitching effect in non-overlapping areas. A comprehensive evaluation shows that the proposed method achieves more accurate image stitching, with significantly reduced ghosting effects in the overlapping regions and more natural results in the other areas. The comparative experiments demonstrate that the proposed method outperforms the state-of-the-art image stitching warps and achieves higher precision panorama stitching and less distortion in the overlapping. The proposed algorithm illustrates great application potential in image stitching, which can achieve higher precision panoramic image stitching

Interference mechanism in coalbed methane wells and impacts on infill adjustment for existing well patterns

This research was funded by the National Natural Science Foundation of China (grant nos. 41830427, 42130806 and 41922016), 2021 Graduate Innovation Fund Project of China University of Geosciences, Beijing (grant no. ZD2021YC035) and the Fundamental Research Funds for Central Universities, China (grant no. 2-9-2021-067). We are very grateful to the reviewers and editors for their valuable comments and suggestions.Peer reviewedPublisher PD

Jasmonate mediates salt-induced nicotine biosynthesis in tobacco (Nicotiana tabacum L.)

AbstractJasmonate (JA), as an important signal, plays a key role in multiple processes of plant growth, development and stress response. Nicotine and related pyridine alkaloids in tobacco (Nicotiana tabacum L.) are essential secondary metabolites. Whether environmental factors control nicotine biosynthesis and the underlying mechanism remains previously unreported. Here, we applied physiological and biochemical approaches to investigate how salt stress affects nicotine biosynthesis in tobacco. We found that salt stress induced the biosynthesis of JA, which subsequently triggered the activation of JA-responsive gene expression and, ultimately, nicotine synthesis. Bioinformatics analysis revealed the existence of many NtMYC2a-recognized G-box motifs in the promoter regions of NtLOX, NtAOS, NtAOC and NtOPR genes. Applying exogenous JA increased nicotine content, while suppressing JA biosynthesis reduced nicotine biosynthesis. Salt treatment could not efficiently induce nicotine biosynthesis in transgenic anti-COI1 tobacco plants. These results demonstrate that JA acts as the essential signal which triggers nicotine biosynthesis in tobacco after salt stress

Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

Bipolar disorder (BD) is a serious mental illness with substantial common variant heritability. However, the role of rare coding variation in BD is not well established. We examined the protein-coding (exonic) sequences of 3,987 unrelated individuals with BD and 5,322 controls of predominantly European ancestry across four cohorts from the Bipolar Sequencing Consortium (BSC). We assessed the burden of rare, protein-altering, single nucleotide variants classified as pathogenic or likely pathogenic (P-LP) both exome-wide and within several groups of genes with phenotypic or biologic plausibility in BD. While we observed an increased burden of rare coding P-LP variants within 165 genes identified as BD GWAS regions in 3,987 BD cases (meta-analysis OR = 1.9, 95% CI = 1.3-2.8, one-sided p = 6.0 × 1