Evaluación de los factores determinantes del recuento de plaquetas en pacientes con cirrosis

Thrombocytopenia is considered one of the hallmarks of patients with cirrhosis. Several mechanisms have been implicated in the pathophysiology of thrombocytopenia in cirrhosis. Hypersplenism caused by splenomegay, classically regarded as an indirect marker of portal hypertension has been considered the main factor implicated [200]. Nevertheless, portal hypertension is best estimated by the hepatic venous pressure gradient (HVPG) [32, 189], although contradictory results have been reported regarding the association between HVPG and platelet count [195-197]. The identification of thrombopoietin (TPO), a growth factor that enhances the maturation of megakaryocytes and the release of platelets from the bone marrow, has shed new light on the physiolgy of platelets [217]. In normal conditions in adults, TPO is mainly produced in the liver [93, 96] and the circulating leves of platelets are controlled by a negative feedback mechanism [99], so there is an inverse relationship between the amount of circulating platelets, and the amount of TPO that can reach the bone marrow to stimulate thrombopoiesis. In liver cirrhosis perhaps a decreased syntehesis of TPO could be implicated in the development of thrombocytopenia. Controversial findings regarding the role of each mechanism in thrombocytopenia of liver cirrhosis have been reported [142, 146, 160-161, 184] and no study has simultaneously evaluated the influence of the different mechanisms including portal hypertension and TPO production nor whether their influence could change in different stages of the disease..

Hydrochloric Acid-Promoted Intermolecular 1,2-Thiofunctionalization of Aromatic Alkenes

An efficient method for making 1,2-thiofunctionalized products via the difunctionalization of aromatic alkenes was developed. In this method, cheap and readily available hydrochloric acid was used to promote 1,2-thiofunctionalization of aryl alkenes with <i>N</i>-arylsulfenylphthalimide and different types of nucleophiles. Importantly, extension of nucleophiles can reach aryl ethers, indoles, and carboxylic acids with good reactivity. This practical and convenient method has broad substrate scope and high yields under metal-free and mild conditions. Furthermore, we achieved conversion and application for making sulfoxide and sulfone by oxidation

Four essential procedures.

<p>Four essential procedures.</p

Comparison of key model components and solution methods in the existing train-set utilization research.

<p>Comparison of key model components and solution methods in the existing train-set utilization research.</p

The relationship between the train graph and the train-set utilization plan.

<p>The relationship between the train graph and the train-set utilization plan.</p

The weight of maintenance arcs.

<p>The weight of maintenance arcs.</p

Effect of traffic density on drivers’ lane change and overtaking maneuvers in freeway situation—A driving simulator–based study

<p><b>Objective:</b> The aim of this study is to examine the effect of traffic density on drivers’ lane change and overtaking maneuvers. The differences between drivers’ left and right lane changing/overtaking maneuvers were also investigated.</p> <p><b>Method:</b> A driving simulator experiment was conducted and 24 participants took part in this experiment. Based on the driving simulation data, lane change frequency, time duration, average speed, and acceleration were extracted as key variables of lane change maneuvers; overtaking frequency, overtaking duration, initial overtaking distance and headway, instantaneous speed, and acceleration before overtaking were analyzed as the key overtaking variables. One-way repeated measures analysis of variance (ANOVA), the Friedman test, and the Wilcoxon signed rank test were adopted for hypothesis tests with a significance level of .05. Further pairwise comparisons were performed with a Bonferroni correction for multiple comparisons.</p> <p><b>Results:</b> Some significant differences in lane change and overtake behaviors were observed among different traffic densities: (1) both lane change and overtaking frequencies significantly increase with traffic density; (2) the average lane change acceleration and instantaneous overtaking acceleration significantly increase with traffic density; (3) as the traffic density increases, the initial overtaking distance and headway decrease. As for the effect of the directions of maneuvers, the (1) time duration of lane change and overtaking from the right side was significantly shorter than that from the left side; (2) right initial overtaking distance/headway was smaller than that of the left side; (3) right instantaneous overtaking acceleration was significantly higher than the left instantaneous acceleration.</p> <p><b>Conclusions:</b> The results showed that as traffic density increases, drivers’ lane changing and overtaking intentions are enhanced. Both initial overtaking distance and headway decrease with traffic density, which might influence road safety. In addition, drivers do not show a preference on the directions of lane change or overtaking according to frequency. However, drivers tend to be more decisive and reckless when overtaking on the right because of a smaller distance/headway before overtaking, higher instantaneous acceleration, and a more restricted field of view compared with overtaking on the left.</p

The topological structure of Beijing-Tianjin passenger dedicated line.

<p>The topological structure of Beijing-Tianjin passenger dedicated line.</p

Results of the comparison between the ant colony algorithm and the two-stage approach.

<p>Results of the comparison between the ant colony algorithm and the two-stage approach.</p

Descriptive statistical results and logistic regression results for COR.

<p>Descriptive statistical results and logistic regression results for COR.</p