Additional file 2: of Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients

Figure S1. Association between CD8+ T cells and overall survival in the discovery set and validation set. (A,C) Kaplan-Meier analysis of overall survival in the discovery set and validation set based on CD8+ T cells infiltration (B,D) Kaplan-Meier analysis of overall survival in the discovery set and validation set based on combination of TIMs and CD8+ T cells infiltration. (TIFF 652 kb

Additional file 1: of Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients

Table S1. Association between CD8+ T cells infiltration and patient characteristics. (DOC 64 kb

Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population

<div><p>Non-small cell lung cancer is one of the most common cancers and the leading cause of cancer death worldwide. Genetic variants in regulatory regions of some miRNAs might be involved in non-small cell lung cancer susceptibility and survival. rs12220909 (G/C) genetic polymorphism in miR-4293 has been shown to be associated with decreased risk of esophageal squamous cell carcinoma. However, the influence of rs12220909 genetic variation on non-small cell lung cancer susceptibility has not been reported. In order to evaluate the potential association between miR-4293 rs12220909 and non-small cell lung cancer risk in a Chinese population, we performed a case-control study among 998 non-small cell lung cancer cases and 1471 controls. The data shows that miR-4293 rs12220909 was significantly associated with decreased susceptibility to non-small cell lung cancer (GC vs.GG: OR = 0.681, 95%CI = 0.555–0.835, <i>P</i> = 2.19E-4; GG vs. GC+CC: OR = 0.687, 95%CI = 0.564–0.837, <i>P</i> = 1.95E-4), which indicates that rs12220909 in miR-4293 may play a significant role in the development of non-small cell lung cancer.</p></div

Genotype frequencies of miR4293 rs12220909 and association with NSCLC.

<p>Genotype frequencies of miR4293 rs12220909 and association with NSCLC.</p

Stratified results for pri-miR-4293 rs12220909 G>C in the heterozygous model.

<p>Stratified results for pri-miR-4293 rs12220909 G>C in the heterozygous model.</p

Stratified results for pri-miR-4293 rs12220909 G>C in the dominant model.

<p>Stratified results for pri-miR-4293 rs12220909 G>C in the dominant model.</p