2 research outputs found
Smart Macroporous Salecan/Poly(<i>N</i>,<i>N</i>‑diethylacrylamide) Semi-IPN Hydrogel for Anti-Inflammatory Drug Delivery
PolyÂ(<i>N</i>,<i>N</i>-diethylacrylamide) is
not only a thermosensitive polymer, but also a good hydrogen bond
acceptor. Therefore, drugs with carboxyl groups can serve as hydrogen
bond donors and form interactions with the tertiary amide groups in <i>N</i>,<i>N</i>-diethylacrylamide. Herein, we report
a novel drug delivery system for anionic drugs composed of polyÂ(<i>N</i>,<i>N</i>-diethylacrylamide) and salecan. Salecan
was used to improve the hydrophilicity and accelerate the responsive
rate of this system. As expected, salecan-enriched hydrogels exhibited
higher swelling ratios and were more sensitive to temperature. Moreover,
scanning electron microscopy images showed that the hydrogels are
superporous structures, with pore-sizes that increase with salecan
concentration. The swelling ratios decreased continuously with the
increase of temperature in the range 25–37 °C. MTT assay
for cell viability and cell adhesion studies confirm the cell compatibility
of the system. Delivery tests using diclofenac sodium, an anti-inflammatory
drug, indicate that the thermosensitive property of this system is
favorable for anionic drug delivery. Interestingly, the release rates
of diclofenac sodium from the hydrogels were temperature dependent,
with higher temperatures contributing toward faster release rate
Fabrication and Characterization of a Novel Anticancer Drug Delivery System: Salecan/Poly(methacrylic acid) Semi-interpenetrating Polymer Network Hydrogel
Salecan
is a novel linear extracellular polysaccharide with a linear backbone
of 1–3-linked glucopyranosyl units. Salecan is suitable for
preparing hydrogels for biomedical applications due to its prominent
physicochemical and biological profiles. In this contribution, a variety
of innovative semi-interpenetrating polymer network (semi-IPN) hydrogels
consisting of Salecan and polyÂ(methacrylic acid) (PMAA) were developed
via free radical polymerization for controlled drug delivery. The
successful fabrication of the semi-IPNs was verified by Fourier transform
infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and thermogravimetric
(TGA) measurements. Scanning electron microscopy (SEM) and rheology
analyses demonstrated that the morphological and mechanical behaviors
of the resultant hydrogels were strongly affected by the contents
of Salecan and cross-linker <i>N</i>,<i>N</i>′-methylenebisÂ(acrylamide)
(BIS). Moreover, the swelling properties of these hydrogels were systematically
investigated, and the results indicated that they exhibited pH sensitivity.
The drug delivery applications of such fabricated hydrogels were further
evaluated from which doxorubicin (Dox) was chosen as a model drug
for in vitro release and cell viability studies. It was found that
the Dox release from the Dox-loaded hydrogels was significantly accelerated
when the pH of the release media decreased from 7.4 to 5.0. Toxicity
assays confirmed that the blank hydrogels had negligible toxicity
to normal cells, whereas the Dox-loaded hydrogels remained high in
cytotoxicity for A549 and HepG2 cancer cells. All of these attributes
implied that the new proposed semi-IPNs serve as potential drug delivery
platforms for cancer therapy