Data_Sheet_1_Secular trends in the epidemiologic patterns of peripheral artery disease and risk factors in China from 1990 to 2019: Findings from the global burden of disease study 2019.docx

BackgroundAn understanding of the epidemiologic patterns of peripheral artery disease is essential in public health policy-making. We aimed to assess secular trends in the epidemiologic patterns and risk factors of peripheral artery disease from 1990 to 2019 in China.Materials and methodsWe extracted data on prevalence, incidence, death, and disability-adjusted life years (DALYs) due to peripheral artery disease from the Global Burden of Disease study 2019. In addition, risk factors for peripheral artery disease were reported.ResultsThe age-standardized prevalence of peripheral artery disease significantly increased from 1330.42 to 1423.78 per 100,000 population, with an average annual percentage change (AAPC) of 0.16 [95% confidence interval (CI), 0.07 to 0.24] from 1990 to 2019 in China. In addition, the age-standardized mortality rate significantly increased, with an AAPC of 0.62 (95% CI, 0.54 to 0.7), contrasting with the significantly declining trend in age-standardized DALYs (AAPC, −0.45; 95% CI, −0.52 to −0.39) between 1990 and 2019. The age-standardized prevalence was almost three times higher in females than males [2022.13 (95% CI: 1750 to 2309.13) vs. 744.96 (95% CI: 644.62 to 850.82) per 100,000 population] in 2019. The age-specific incidence significantly increased in individuals aged 40–44, 45–49, 50–54, 55–59, and 60–64 years groups but decreased in 70–74, 75–79, and 80–84 years groups. The age and period effects showed that the relative risks of incident peripheral artery disease increased with age and time. The cohort assessment showed that the incidence decreased in successive birth cohorts. Smoking was identified as the risk factor that contributed the most to age-standardized DALYs of peripheral artery disease in 2019.ConclusionThe burden of peripheral artery disease showed unexpected patterns that varied by age, sex, and year in China. More attention should be given to addressing the increasing incidence among middle-aged individuals and mortality among males.</p

Table_2_Long-term outcomes of adult cryptogenic febrile infection–related epilepsy syndrome (FIRES).docx

BackgroundCryptogenic febrile infection-related epilepsy syndrome (FIRES) is a rare but catastrophic encephalopathic condition. We aimed to investigate the long-term outcome in adult cryptogenic FIRES.MethodsThis was a retrospective study based on the prospective database in the neuro-intensive care unit of a tertiary hospital in China. Consecutive adult patients with cryptogenic FIRES between July 2007 to December 2021 were included. Long-term outcomes included function independence, the development of drug-resistant epilepsy (DRE), remote recurrent status epilepticus (SE), anti-seizure medications (ASMs), and changes in the brain Magnetic Resonance Imaging (MRI).ResultsA total of 11 adult patients with cryptogenic FIRES were identified from 270 patients with SE. Four (36%) patients died in the hospital, with three of them withdrawing treatments, and one patient died 12 months after discharge. After the follow-up ranging from 12 to 112 months, 6 (55%) patients were still alive, and all of them achieved functional independence [modified Rankin Scale (mRS) 0-3]. 45% (5/11) patients developed DRE, 18% (2/11) had remote recurrent SE, and 55% (6/11) were on polytherapy with ASMs at the last follow-up. Most of the patients with initial normal or abnormal MRI had abnormalities in the hippocampus at follow-up, and most of the other MRI abnormalities found in the acute stage disappeared over time.ConclusionThe outcome of adult cryptogenic FIRES is daunting. More than one-third of patients die in the hospital. Survivors of cryptogenic FIRES may regain functional independence, but they usually develop DRE and receive polytherapy of ASMs for a long time.</p

DataSheet_1_Assessment of marine protected areas in the East China Sea using a management effectiveness tracking tool.zip

Marine protected areas (MPAs) are important tools for maintaining biodiversity, mitigating climate change, and conserving and restoring natural ecosystems. Management effectiveness assessment is an important component of conservation management in protected areas. In this study, we constructed a management effectiveness assessment tool based on publicly available information for China, with a total score of 126. We used the tool to systematically assess 27 national MPAs in the East China Sea. Our results showed that marine nature reserves (MNRs) and marine special reserves (MSRs) could be classified into two and three classifications, respectively, including MNRs I (n = 4, scores = 88-100), MNRs II (n = 6, scores = 75-81), MSRs I (n = 8, scores = 75-90), MSRs II (n = 6, scores = 59-75) and MSRs III (n = 3, scores = 53-56). Factors influencing the management effectiveness of nature reserves were the length of establishment and general public budget revenue, while for special reserves they were the length of establishment and total agricultural output value. Furthermore, protected areas with high management effectiveness scores tend to have a longer establishment time, dedicated management departments, adequate management staff and financial investment compared to those with low scores. In addition, the low-score MPAs require more communication with stakeholders. The study provides an objective and comprehensive systematic scoring of MPAs’ management using METT-based framework and multi-source data. It overcomes the challenge of the general lack of data on MPAs and provides a new approach to management effectiveness assessment.</p

Table_3_Long-term outcomes of adult cryptogenic febrile infection–related epilepsy syndrome (FIRES).docx

BackgroundCryptogenic febrile infection-related epilepsy syndrome (FIRES) is a rare but catastrophic encephalopathic condition. We aimed to investigate the long-term outcome in adult cryptogenic FIRES.MethodsThis was a retrospective study based on the prospective database in the neuro-intensive care unit of a tertiary hospital in China. Consecutive adult patients with cryptogenic FIRES between July 2007 to December 2021 were included. Long-term outcomes included function independence, the development of drug-resistant epilepsy (DRE), remote recurrent status epilepticus (SE), anti-seizure medications (ASMs), and changes in the brain Magnetic Resonance Imaging (MRI).ResultsA total of 11 adult patients with cryptogenic FIRES were identified from 270 patients with SE. Four (36%) patients died in the hospital, with three of them withdrawing treatments, and one patient died 12 months after discharge. After the follow-up ranging from 12 to 112 months, 6 (55%) patients were still alive, and all of them achieved functional independence [modified Rankin Scale (mRS) 0-3]. 45% (5/11) patients developed DRE, 18% (2/11) had remote recurrent SE, and 55% (6/11) were on polytherapy with ASMs at the last follow-up. Most of the patients with initial normal or abnormal MRI had abnormalities in the hippocampus at follow-up, and most of the other MRI abnormalities found in the acute stage disappeared over time.ConclusionThe outcome of adult cryptogenic FIRES is daunting. More than one-third of patients die in the hospital. Survivors of cryptogenic FIRES may regain functional independence, but they usually develop DRE and receive polytherapy of ASMs for a long time.</p

Table_1_Long-term outcomes of adult cryptogenic febrile infection–related epilepsy syndrome (FIRES).docx

BackgroundCryptogenic febrile infection-related epilepsy syndrome (FIRES) is a rare but catastrophic encephalopathic condition. We aimed to investigate the long-term outcome in adult cryptogenic FIRES.MethodsThis was a retrospective study based on the prospective database in the neuro-intensive care unit of a tertiary hospital in China. Consecutive adult patients with cryptogenic FIRES between July 2007 to December 2021 were included. Long-term outcomes included function independence, the development of drug-resistant epilepsy (DRE), remote recurrent status epilepticus (SE), anti-seizure medications (ASMs), and changes in the brain Magnetic Resonance Imaging (MRI).ResultsA total of 11 adult patients with cryptogenic FIRES were identified from 270 patients with SE. Four (36%) patients died in the hospital, with three of them withdrawing treatments, and one patient died 12 months after discharge. After the follow-up ranging from 12 to 112 months, 6 (55%) patients were still alive, and all of them achieved functional independence [modified Rankin Scale (mRS) 0-3]. 45% (5/11) patients developed DRE, 18% (2/11) had remote recurrent SE, and 55% (6/11) were on polytherapy with ASMs at the last follow-up. Most of the patients with initial normal or abnormal MRI had abnormalities in the hippocampus at follow-up, and most of the other MRI abnormalities found in the acute stage disappeared over time.ConclusionThe outcome of adult cryptogenic FIRES is daunting. More than one-third of patients die in the hospital. Survivors of cryptogenic FIRES may regain functional independence, but they usually develop DRE and receive polytherapy of ASMs for a long time.</p

Morphology Control, Crystal Growth, and Growth Mechanism of Hierarchical Tellurium (Te) Microstructures

Understanding the factors that influence the growth and final shape of semiconductor tellurium microstructures is important for controlling their properties. However, relative to their single-crystalline nanostructures, the growth of complex structures that are ideally composed of nanostructures arranged in a particular way can be difficult to control. Here, we developed a facile solvothermal method and successfully completed the controlled synthesis of Te particles with distinctive morphologies, including flower-like, ball-flower, nestlike, and sheetlike structures. These structures, self-assembled from nanorods and nanosheets, are systematically studied by adjusting the reaction parameters, such as the amount of NaOH, the volume ratio of EG/EN, the amount of PVP, and the reaction time. Results reveal that the morphology of Te microstructures can be easily controlled by simply altering the reaction conditions and that NaOH plays a crucial role in the final morphology of Te products. The growth mechanisms and morphology control of hierarchical Te microstructures are proposed and discussed. This is the first time to report the preparation of complex hierarchical Te microstructures through a simple solution route. This simple solution approach to fabricate hierarchical Te superstructures with controllable morphologies can be easily scaled up and potentially extended to the hierarchical assembly of building blocks of other semiconductors

Synthesis of High Saturation Magnetization Superparamagnetic Fe₃O₄ Hollow Microspheres for Swift Chromium Removal

High saturation magnetization monodisperse Fe₃O₄ hollow microspheres (109.48 emu/g) with superparamagnetic property at room temperature are promptly synthesized by a one-step solvothermal process with the presence of sodium dodecylbenzenesulfonate as an additive. The as-synthesized products possess superparamagnetism, large cavity, high water solubility, and saturation magnetization at room temperature. In particular, these hollow microspheres exhibit both of a rather short separation time from industry wastewater and a high adsorption capacity about 180 mg/g at high Cr­(VI) concentrations, which is much better than those of reported magnetite solid nanoparticles. In addition, the X-ray photoelectron spectra (XPS) show that the uptake of Cr­(VI) into the spheres was mainly governed by a physicochemical process. The micelle-assisted Ostwald ripening process was proposed to explain the rapid formation of hollow structures by a series of control experiments. The as-manufactured products with the two advantages mentioned above serve as ideal candidates for environmental remediation materials

Table_1_UV RESISTANCE LOCUS 8 From Chrysanthemum morifolium Ramat (CmUVR8) Plays Important Roles in UV-B Signal Transduction and UV-B-Induced Accumulation of Flavonoids.XLS

<p>UV Resistance Locus 8 (UVR8), an ultraviolet-B (UV-B; 280–315 nm) photoreceptor, participates in the regulation of various plant growth and developmental processes. UV-B radiation is an important factor enhancing the production of active components in medicinal plants. To-date, however, studies on UV-B photoreceptors have largely focused on Arabidopsis, and the functions of UVR8 in medicinal plants are still largely unknown. In the present study, a homolog of Arabidopsis UVR8, CmUVR8, was isolated from Chrysanthemum morifolium Ramat, and its structure and function were analyzed in detail. Protein sequence analysis showed that CmUVR8 contained nine conserved regulators of chromosome condensation 1 repeats, seven conserved bladed propellers, one C27 region, three “GWRHT” motifs and several crucial amino acid residues (such as 14 Trps and 2 Args), similar to AtUVR8. 3-D structural analysis of CmUVR8 indicated that its structure was similar to AtUVR8. Heterologous expression of CmUVR8 could rescued the deficient phenotype of uvr8-6, a mutant of UVR8 in Arabidopsis, indicating the role of CmUVR8 in the regulation of hypocotyl elongation and HY5 gene expression under UV-B irradiation. Moreover, CmUVR8 regulates UV-B-induced expression of four flavonoids biosynthesis-related genes and the UV-B-induced accumulation of flavonoids. Furthermore, the interaction between CmUVR8 and CmCOP1 were confirmed using a yeast two-hybrid assay. These results indicated that CmUVR8 plays important roles in UV-B signal transduction and the UV-B-induced accumulation of flavonoids, as a counterpart of AtUVR8.</p