Copper-Catalyzed [4 + 1] Annulation between α‑Hydroxy Ketones and Nitriles: An Approach to Highly Substituted 3(2<i>H</i>)‑Furanones

A copper-catalyzed [4 + 1] annulation between α-hydroxy ketones and nitriles has been developed. The reaction provides a facile and efficient method for the construction of a wide range of highly substituted 3­(2<i>H</i>)-furanones, a class of important compounds known to be associated with several biological activities

Additional file 1 of Two cases of successful sirolimus treatment for patients with activated phosphoinositide 3-kinase δ syndrome 1

Additional file 1: Figure S1. The protein expression levels of pAKT, pS6 and IL2 in patient 2. Phosphorylation of AKT, S6 and IL2 in patient 2 were significantly higher than in the control group. All data are presented as mean ± SD (n = 3). *p < 0.05, **p < 0.01

Additional file 1: of OX40 signaling is involved in the autoactivation of CD4+CD28− T cells and contributes to the pathogenesis of autoimmune arthritis

Supplementary figures and tables. (DOC 614 kb