Additional file 9 of Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins

Additional file 9: Figure S2. Relationships between consensus module eigengenes and external trait. Each row in the table corresponds to a consensus module, and each column to a trait. Numbers in the table report the correlations of the corresponding module eigengenes and trait with the P-values printed below the correlations in parentheses. The table is color coded by correlation according to the shade of color legend. FPG, fasting plasma glucose

Manhattan plot for bivariate genome-wide association study of grip strength and depression.

The horizontal axis represents autosomes and the X chromosome, while the vertical axis represents the P-values of SNPs. The red line represents the genome-wide significance threshold (5×10−8), and the lower horizontal dashed line represents the suggestive significance level (1×10−5).</p

Additional file 2 of Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins

Additional file 2: Figure S1. Circular Manhattan plot for epigenome-wide association study on fasting plasma glucose. The numbers of chromosome and the -log10 of P-values for statistical significance are shown. Dots represent the observed CpGs

Expression quantitative trait loci (eQTL) analysis of rs10914387 with SERINC2 across tissue types from the GTEx database.

NES is the normalized effect size (β) from single-tissue eQTL analysis. P-value is from the t-test that compares observed NES in single-tissue eQTL analysis to the null hypothesis of no NES. m-value represents a posterior probability that the effect of eQTL exists in each tissue of a cross-tissue meta-analysis. (TIF)</p

Quantile-quantile plot for bivariate genome-wide association study of grip strength and depression.

The horizontal axis represents the expected -log10 (P), while the vertical axis represents the observed -log10 (P). The red line represents the expectation of the null hypothesis of no association, and the gray shaded area represents 95% confidence intervals of the null hypothesis. The black dots represent the observed data, and λ indicates genomic inflation.</p

Additional file 8 of Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins

Additional file 8: Table S7. Validation analysis results for the CpGs mapped to SLC6A18 gene

Expression quantitative trait loci (eQTL) analysis of rs10914386 with SERINC2 across tissue types from the GTEx database.

NES is the normalized effect size (β) from single-tissue eQTL analysis. P-value is from the t-test that compares observed NES in single-tissue eQTL analysis to the null hypothesis of no NES. m-value represents a posterior probability that the effect of eQTL exists in each tissue of a cross-tissue meta-analysis. (TIF)</p

Characteristics of participants by sex.

Characteristics of participants by sex.</p

The results of pleiotropy analysis for bivariate GWAS of grip strength-depression identified top 15 SNPs.

The results of pleiotropy analysis for bivariate GWAS of grip strength-depression identified top 15 SNPs.</p

Additional file 7 of Identification of key DNA methylation changes on fasting plasma glucose: a genome-wide DNA methylation analysis in Chinese monozygotic twins

Additional file 7: Table S6. Basic characteristics of participants from the community in the quantitative methylation analysis of SLC6A18 gen