The expression levels of microRNA-126 in Non-small cell lung cancers.

<p>The expression levels of microRNA-126 in Non-small cell lung cancers.</p

MicroRNA-126 inhibits cell invasion and tumor growth.

<p>(A) Overe-xpression of microRNA-126 inhibits the cell invasion in A549 and SK-MES-1 cells. Compared with the control group, over-expression of microRNA-126 impaires cell invasion. (B) MicroRNA-126 impairs the cell proliferation in A549 and SK-MES-1 cells. The cell proliferation was dramatically decreased after cells were treated with microRNA-126 over-expression for 72 hours. (C) The tumor growth curve <i>in vivo</i> by intratumoral injection with microRNA-126. The growth of tumors was observed from 1 to 25 days after the last injection. (D) MicroRNA-126 inhibits growth of A549 cell and SK-MES-1 cells in vivo. The average tumor only about an half of the tumors weight in the mice treated with PBS or pE-CMV vector alone.</p

Low expression levels of microRNA-126 correlate with poor survival of NSCLC patients.

<p>(A) The expression levels of microRNA-126 are decreased in NSCLC cell lines. Expression of microRNA-126 was examined by quantitative real-time PCR in NL20 cell lines and NSCLC cell lines. (B) The expression levels of microRNA-126 are decreased in Human NSCLC specimens. Expression of microRNA-126 was determined by quantitative real-time PCR in tumor tissues and patient-matched adjacent lung tissues. Compared with the corresponding adjacent lung tissues, microRNA-126 expression was markedly down-regulated in tumor tissues (<i>P</i><0.0001). (C) Low microRNA-126 expression correlates with poor survival of NSCLC patients. Patients were divided into two groups based on their microRNA-126 expression levels: those with less than median of microRNA-126 expression levels and those with more than or equal to median of microRNA-126 expression levels (median: 0.654). The patients with low microRNA-126 expression had significantly poor survival time compared with those with high microRNA-126 expression (means for survival time (month):24.392±1.055 vs. 29.282±1.140, <i>P</i> = 0.005).</p

Clinical factors of patients correlate with overall survival by multivariate Cox proportional hazard regression analysis.

<p>Clinical factors of patients correlate with overall survival by multivariate Cox proportional hazard regression analysis.</p

Genotype of microRNA-126 polymorphisms and their associations with NSCLC risk.

<p>Genotype of microRNA-126 polymorphisms and their associations with NSCLC risk.</p

One-Pot Synthesis of Fe₂O₃ Nanoparticles on Nitrogen-Doped Graphene as Advanced Supercapacitor Electrode Materials

Fe₂O₃ supported on nitrogen-doped graphene (Fe₂O₃/N-rGO) hydrogel was prepared by a facial one-pot hydrothermal method. The efficient Fe₂O₃ loading and nitrogen doping of graphene was realized with this method. The morphology and structure of the samples were characterized by scanning electron microscopy, high-resolution transmission electron microscopy, thermal gravimetric analysis, Raman spectra, X-ray diffraction, and nitrogen isothermal adsorption–desorption. The chemical environment of the surface composition of the samples was recorded by X-ray photoelectron spectroscopy. The electrochemical performance was tested with a three-electrode system in the aqueous electrolyte of 1 M KOH. The electrochemical measurement demonstrated that Fe₂O₃/N-rGO shows a specific capacitance as high as 618 F g^–1 at a discharge current density of 0.5 A g^–1. Even at the current density of 10 A g^–1, the specific capacitance is still as high as 350 F g^–1. After 5000 cycles, the capacity retention is still maintained at 56.7%

Genetic variant within microRNA-126 is not associated with the survival times and microRNA-126 expression levels in NSCLC patients.

<p>(A) Genetic variant within microRNA-126 is not associated with survival times. Kaplan-Meier survival estimates show that there is no association between SNP rs4636297 and survival time in NSCLC patients (<i>P</i> = 0.992). (B). Expression levels of microRNA-126 in NSCLC tissues of three genotypes are similar. MicroRNA-126 expression was determined by quantitative real-time PCR. There was no significant difference among the three genotype groups (<i>P</i> = 0.972).</p

The expression levels of PIK3R2 and the phosphorylation levels of Akt in NSCLC tissues.

a<p>Patients were divided into two groups with low and high microRNA-126 expression levels, based on their microRNA-126 expression levels: those with less than median of microRNA-126 expression levels and those with more than or equal to median of microRNA-126 expression levels (median: 0.654).</p

Nanoparticle-Stacked Porous Nickel–Iron Nitride Nanosheet: A Highly Efficient Bifunctional Electrocatalyst for Overall Water Splitting

Nanoparticle-stacked porous Ni₃FeN nanosheets were synthesized through a simple nitridation reaction of the corresponding LDHs. The nanosheet is composed of stacked nanoparticles with more active sites exposed for electrocatalytic reactions. Thus, it exhibited excellent oxygen evolution reaction performance having an extremely low overpotential of 223 mV at 10 mA/cm² and hydrogen evolution reaction property with a very low overpotential of 45 mV at 10 mA/cm². This electrocatalyst as bifunctional electrodes is used to overall water splitting in alkaline media, showing a high performance with 10 mA/cm² at a cell voltage of 1.495 V

Co₃O₄–CeO₂/C as a Highly Active Electrocatalyst for Oxygen Reduction Reaction in Al–Air Batteries

Developing high-performance and low-cost electrocatalysts for oxygen reduction reaction (ORR) is still a great challenge for Al–air batteries. Herein, CeO₂, a unique ORR promoter, was incorporated into ketjenblack (KB) supported Co₃O₄ catalyst. We developed a facile two-step hydrothermal approach to fabricate Co₃O₄–CeO₂/KB as a high-performance ORR catalyst for Al–air batteries. The ORR activity of Co₃O₄/KB was significantly increased by mixing with CeO₂ nanoparticles. In addition, the Co₃O₄–CeO₂/KB showed a better electrocatalytic performance and stability than 20 wt % Pt/C in alkaline electrolytes, making it a good candidate for highly active ORR catalysts. Co₃O₄–CeO₂/KB favored a four-electron pathway in ORR due to the synergistic interactions between CeO₂ and Co₃O₄. In full cell tests, the Co₃O₄–CeO₂/KB exhibited a higher discharge voltage plateau than CeO₂/KB and Co₃O₄/KB when used in cathode in Al–air batteries